×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
22327296
2012
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
High frequencies of MEN1 gene mutations were detected in Brazilian families with MEN1 , including seven new genetic mutations that are predicted to cause inactivation of the MEN1 tumour suppressor gene.
17555499
2007
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
We have identified four novel mutations in the MEN1 gene in patients with MEN1 in Taiwan.
15730416
2005
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
Clinical testing for multiple endocrine neoplasia type 1 in a DNA diagnostic laboratory.
15714081
2005
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
The cellular function of the menin tumor suppressor protein, product of the MEN1 gene mutated in familial multiple endocrine neoplasia type 1 , has not been defined.
14992727
2004
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
Efficient mutation detection in MEN1 gene using a combination of single-strand conformation polymorphism (MDGA) and heteroduplex analysis.
12652570
2003
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
A novel missense mutation of the MEN1 gene in a multiple endocrine neoplasia type 1 patient associated with carcinoid syndrome.
14686752
2003
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
Screening of the genetic variations of the MEN1 gene revealed four germline mutations in five typical MEN1 families.
12791038
2003
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
Mutational and gross deletion study of the MEN1 gene and correlation with clinical features in Spanish patients.
12746426
2003
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
Multiple endocrine neoplasia type 1 (MEN1) germline mutations in familial isolated primary hyperparathyroidism.
12699448
2003
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
A novel six-nucleotide insertion in exon 4 of the MEN1 gene, 878insCTGCAG, in three patients with familial insulinoma and primary hyperparathyroidism.
12417605
2002
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
Frequent occurrence of an intron 4 mutation in multiple endocrine neoplasia type 1.
12050235
2002
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
Taken together, most missense and in-frame MEN1 genomic alterations affect one or all domains of menin interacting with JunD [codons 1-40; 139-242; 323-428], Smad3 [distal to codon 478], and NFkappaB [codons 276-479], three major effectors in transcription and cell growth regulation.
12112656
2002
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
Identification of three novel menin mutations (c.741delGTCA, c.1348T>C, c.1785delA) in unrelated Italian families affected with multiple endocrine neoplasia type 1 : Additional information for mutational screening.
11241849
2001
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
MEN1 gene mutation analysis in Italian patients with multiple endocrine neoplasia type 1 .
10664520
2000
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
Based on our clinical experience with MEN 1 patients/families we formulated clinical criteria to identify disease gene carriers among patients with apparently sporadic MEN 1 -related tumours.
10849016
2000
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
A better understanding of early onset MEN 1 disease is needed to formulate recommendations for early MEN 1 genetic testing.
11134142
2000
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
The entire coding region of the MEN1 gene was sequenced, and mutations were detected in 11 MEN 1 families; one sporadic MEN 1 patient, one case of FIHPT and one MEN 1 -like case.
10993647
2000
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
A novel mutation E179K of the MEN1 gene predisposes for multiple endocrine neoplasia-type 1 (MEN1 ).
11102994
2000
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
We identified heterozygous germline mutations of the MEN1 gene in all of 16 Japanese MEN1 families examined, achieving the highest detectability of MEN1 mutations in familial MEN1 among studies that examined more than 10 families.
10576763
1999
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
Germline mutations in the multiple endocrine neoplasia type 1 gene: evidence for frequent splicing defects.
10090472
1999
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
The MEN1 tumor predisposition syndrome is caused by mutations in the MEN1 gene on human chromosome 11q13.
10534569
1999
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
Mutation analysis of the MEN1 gene in Belgian patients with multiple endocrine neoplasia type 1 and related diseases.
9888389
1999
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
A new mutation of the MEN1 gene in an italian kindred with multiple endocrine neoplasia type 1 .
10229909
1999
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
Multiple Endocrine Neoplasia Type 1
0.900
GeneticVariation
UNIPROT
Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription.
9989505
1999