|
rs1000283
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
The association of common SNPs in HSD11B1 [IVS3-29G/T (rs12086634), IVS4-11120A/G (rs1000283)] and H6PD [R453Q (rs6688832), P554L (rs17368528)], either separately or combined, with type 2 diabetes and metabolic syndrome was examined in 427 Korean subjects with type 2 diabetes and in 358 nondiabetic Korean subjects.
|
21869537 |
2011 |
|
rs10010131
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
All the risk alleles in the 11 examined type 2 diabetes risk variants showed an odds ratio (OR) greater than 1 for the GDM group compared with the control group ranging from 1.13 [95% confidence interval (CI) 0.88-1.46] to 1.44 (95% CI 1.19-1.74) except for the WFS1 rs10010131 variant with OR 0.87 (95% CI 0.73-1.05).
|
18984664 |
2009 |
|
rs10010131
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
Nine variants in FTO rs8050136, WFS1 rs10010131, CDKN2A/B rs10811661, KCNJ11 rs5219, CDC123/CAMK1D rs12779790, JAZF1 rs864745, SLC30A8 rs13266634, CDKAL1 rs10946398, and HHEX/IDE rs5015480 were significantly associated with T2DM (P < 0.05).
|
23298195 |
2013 |
|
rs10010131
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
While FTO rs8050136 and rs17817449, ADAMTS9 rs4607103, and WFS1 rs10010131 were initially associated with T2DM, this was lost upon multiple testing correction.
|
24145053 |
2013 |
|
rs10010131
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
A total of 1,578 non-diabetic individuals (534 men and 1,044 women, aged 40 +/- 13 years, BMI 28.9 +/- 8.2 kg/m(2) [mean +/- SD]) at increased risk of type 2 diabetes were genotyped for rs10010131 within the WFS1 gene.
|
19330314 |
2009 |
|
rs10010131
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
Cox analyses showed an association between the G-allele of rs10010131 and incident type 2 diabetes (HR 1.34, 95% CI 1.08-1.70, p = 0.007).
|
21127832 |
2011 |
|
rs10010131
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our results suggested that the G allele of rs734312 polymorphism [dominant: FEM OR 0.873, 95%CI (0.810 - 0.940), recessive: FEM OR 0.876, 95% CI (0.800 - 0.959)] and A allele of rs10010131 polymorphism [dominant:FEM OR 0.853, 95% CI (0.817 - 0.892), recessive:REM OR 0.833, 95% CI (0.756 - 0.917)] in WFS1 gene had significant protective effects on risk of T2D.
|
23257691 |
2013 |
|
rs10011540
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
The -112A>C polymorphism (rs10011540) of the gene for uncoupling protein 1 (UCP1) has been associated with type 2 diabetes mellitus in Japanese individuals.
|
16338218 |
2006 |
|
rs1001179
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of the present study was to test the association between genetic polymorphisms with functional effects on redox regulation: the -262C/T of the catalase gene promoter (rs1001179), the C242T of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase P22phox gene (rs4673), and the 594C/T polymorphism of the glutathione peroxidase gene (rs1050450) and arterial hypertension (AH) in patients with type 2 diabetes.
|
23701472 |
2014 |
|
rs10012946
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
Examination of the publicly available Diabetes Genetics Initiative genome-wide association dataset revealed that rs10012946, which is in strong linkage disequilibrium with the three WFS1 SNPs (r(2)=0.88-1.0), was associated with type 2 diabetes (allelic odds ratio 0.85, 95% CI 0.75-0.97, p=0.026).
|
18060660 |
2008 |
|
rs1002630
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study showed that the rs1002630 of CHN2 were associated with DR risk and non-proliferative DR risk in Taiwanese individuals with type 2 diabetes.
|
24854763 |
2015 |
|
rs1004467
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
In stratified analyses, rs1004467 and rs12413409 showed significant association with T2DM in the older age group (≥65 years) and, in the case of rs12413409, the risk of T2DM was significant in men but not in women.
|
29942286 |
2018 |
|
rs10181656
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
The allelic and genotypic frequencies of rs10181656 located in the STAT4 gene were not found to be associated with risk of type 2 diabetes.
|
30044774 |
2018 |
|
rs10195252
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.810 |
GeneticVariation
|
BEFREE |
Particularly, gene polymorphisms in ADIPOQ (rs1501299 and rs17300539), LepR (rs1137101 and rs1045895), IRS2 (rs1805092), GRB14 (rs10195252 and rs3923113) and PPARG (rs1801282) have been associated with overweight and obesity in uncontrolled T2DM.
|
26999420 |
2016 |
|
rs10212638
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
These data suggest that Koreans with the minor alleles of PGC-1α rs10517030, rs10517032 and rs10212638 are at greater risk of T2DM, and that a low-energy diet is more protective against the development of T2DM in subjects with the major alleles of rs10517030 and rs10517032.
|
28488691 |
2017 |
|
rs1022113606
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms in extracellular superoxide dismutase Leu53Leu, Arg213Gly, and Ala40Thr and susceptibility to type 2 diabetes mellitus.
|
27966735 |
2016 |
|
rs10229583
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.820 |
GeneticVariation
|
BEFREE |
Our study identifies rs10229583 near PAX4 as a novel locus for type 2 diabetes in Chinese and other populations and provides new insights into the pathogenesis of type 2 diabetes.
|
23532257 |
2013 |
|
rs10229583
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.820 |
GeneticVariation
|
BEFREE |
Objective The rs10229583 polymorphism near paired box gene 4 ( PAX4) is associated with insulin resistance and type 2 diabetes.
|
28730907 |
2018 |
|
rs1024610
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this analysis adjusted by age and gender, the rs3760396 CC genotype was associated with low levels of gamma-glutamyl transpeptidase (P=0.002), whereas, the rs1024610 TT genotype was associated with decreased risk of T2DM (P=0.035) in premature CAD patients.
|
26277553 |
2015 |
|
rs1024611
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
The objective of the present study is to evaluate the association, if any, of g.-2518A>G polymorphism (rs1024611) in MCP-1 gene in T2D cases with and without ESRD in the population of Punjab from North-West India.
|
25154422 |
2015 |
|
rs1024611
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
The results of this study indicate that the use of 8 genetic polymorphisms associated with carbohydrate and lipid metabolism and type 2 diabetes [<i>PTGS2</i> (<i>COX2</i>) rs6681231, <i>FADS1</i> rs174550, <i>HNF1B</i> rs4430796, <i>ADIPOQ</i> rs266729, <i>IL18</i> rs187238, <i>CCL2</i> rs1024611, <i>HHEX</i> rs5015480 and <i>CDKN2A/2B</i> rs10811661] together with clinical risk factors (BMI and age) may significantly improve the prediction of GDM.
|
31299695 |
2019 |
|
rs1024611
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our aim was to evaluate the frequency distribution of MCP1-2518 A/G (rs1024611) polymorphic variants in hemodialysis (HD) patients without or with type 2 diabetes in relation to serological markers of HBV infection.
|
24975639 |
2014 |
|
rs10247649
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
The association of common single nucleotide polymorphisms (SNPs) was examined in PDK4 [-208A/G (rs10085637), IVS3+192C/T (rs3779478), IVS6+31A/G (rs2301630), IVS7+514A/G (rs12668651), IVS10+75C/T (rs10247649)] with type 2 diabetes and metabolic syndrome in 651 Korean subjects with type 2 diabetes and 350 nondiabetic Korean subjects.
|
22019269 |
2012 |
|
rs10255208
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
Minor allele frequencies of rs7782979 and rs10255208 ELMO1 variants were significantly higher among unselected T2DM cases than controls, and significant differences in the distribution of rs7782979 genotypes were seen between T2DM cases and control subjects, which was seen in male but not female subjects.
|
28752301 |
2018 |
|
rs10305420
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
The consistent large clinical impact of rs10305420 on glycemic response and weight response to exenatide makes the variant a strong candidate biomarker for precision medicine, particularly among overweight patients with Type 2 diabetes.
|
30883264 |
2019 |