Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1063537
rs1063537
Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE One intron SNP (rs13306519) in LEPR and one 3'UTR SNP (rs1063537) in ADIPOQ demonstrated a significant association with T2DM (P = 0.024 and 0.014 respectively). 24414038

2014

dbSNP: rs1063538
rs1063538
Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE Varied association of ADIPOQ genotypes with T2DM was seen according to the genetic model used: rs17300539 and rs266729 were significantly associated with T2DM under the three models, while rs16861194 was association with T2DM under additive and dominant models, and rs822396, rs2241766, and rs1063538 were associated with T2DM under the dominant models only. 22497971

2012

dbSNP: rs1063539
rs1063539
Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE In the case-control analysis, PPARG rs1801282 (Pro12Ala) (OR=1.48 (1.02-2.16)), ADIPOQ rs1063539 (OR=1.17 (1.01-1.35)), and HNF4A rs1884614 (OR=1.16 (1.00-1.32) were associated with T2D (P(allelic)<0.05). 22515931

2012

dbSNP: rs1063539
rs1063539
Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE Among these mutations, the 4545G/C mutation (rs1063539) contributed to the genetic risk of T2D in the non-obese group (OR=2.34, 95%CI: 1.31-4.21, P=0.004), and 57% of the risk is related to this polymorphism. 19359061

2009

dbSNP: rs121917815
rs121917815
Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE The silence SNP G15G (+45TN G) in exon 1 and SNP+349ANG in intron 2 also showed a weak association with type 2 diabetes (P=0.06 and P=0.07, respectively),while SNPs−3971ANG in intron 1 and Y111H, R112C and H241P in exon 3 showed no association (P N 0.05). 24404592

2014

dbSNP: rs138773406
rs138773406
Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE We also identified three mutations in exon 3: I164T, R221S, and H241P, but, owing to the low frequencies of them, associations with type 2 diabetes could not be evaluated. 19269196

2010

dbSNP: rs141205818
rs141205818
Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE The silence SNP G15G (+45TN G) in exon 1 and SNP+349ANG in intron 2 also showed a weak association with type 2 diabetes (P=0.06 and P=0.07, respectively),while SNPs−3971ANG in intron 1 and Y111H, R112C and H241P in exon 3 showed no association (P N 0.05). 24404592

2014

dbSNP: rs141205818
rs141205818
Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE We also identified three mutations in exon 3: I164T, R221S, and H241P, but, owing to the low frequencies of them, associations with type 2 diabetes could not be evaluated. 19269196

2010

dbSNP: rs1501299
rs1501299
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Interactions among moderate/severe periodontitis, rs1501299-GG, and rs1137100-GG were associated with an increased risk of T2DM. 31128439

2019

dbSNP: rs1501299
rs1501299
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Particularly, gene polymorphisms in ADIPOQ (rs1501299 and rs17300539), LepR (rs1137101 and rs1045895), IRS2 (rs1805092), GRB14 (rs10195252 and rs3923113) and PPARG (rs1801282) have been associated with overweight and obesity in uncontrolled T2DM. 26999420

2016

dbSNP: rs1501299
rs1501299
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Adiponectin rs2241766T/G and rs17300593G/A rather than rs1501299G/T and rs266729C/G polymorphisms were associated with the risk of DN in T2DM, especially in the Caucasian population. 24825737

2015

dbSNP: rs1501299
rs1501299
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Of the 8 variants, four SNPs namely, +276 G/T (rs1501299), -4522 C/T (rs822393), -11365 C/G (rs266729), and +712 G/A (rs3774261) were significantly associated with T2DM in our study population. 24055485

2013

dbSNP: rs1501299
rs1501299
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Rs2241766 and rs1501299 of ADIPOQ were genotyped in 708 patients with T2DM. 23260797

2013

dbSNP: rs1501299
rs1501299
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE To derive a more precise estimation, we performed a meta-analysis to assess the association between five AdipoQ polymorphisms [-11426A > G (rs16861194), -11391G > A (rs17300539), -11377C > G (rs266729), +45T > G (rs2241766) and +276G > T (rs1501299)], and T2DM risk. 23653335

2013

dbSNP: rs1501299
rs1501299
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Thus, we concluded on the basis of observed results that the ADIPOQ gene polymorphisms rs822396 and rs1501299 plays an important role in the development of type 2 diabetes in North Indian Punjabi population. 31755094

2019

dbSNP: rs1501299
rs1501299
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Two individual polymorphisms (ADIPOQ rs1501299, KCNJ11 rs5219) were found to be associated with T2D. 30467975

2019

dbSNP: rs1501299
rs1501299
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE This study observed that the SNPs rs3792267 in CAPN10, rs1501299 in APM1, and rs3760776 in FUT6 might serve as potential susceptible biomarkers for T2DM in Uyghurs. 27374856

2016

dbSNP: rs1501299
rs1501299
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The presence of +45T>G (rs2241766), +276G>T (rs1501299) and -11391G>A (rs17300539) do not appear to influence the development of type 2 diabetes. 21638131

2011

dbSNP: rs1501299
rs1501299
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE In conclusion, our meta-analysis suggested that the ADIPOQ rs1501299 (+276G>T) polymorphism is a low-risk factor for the development of CVDs with T2D, but the association of this polymorphism with the susceptibility to CVDs in other populations remains unknown. 22040602

2012

dbSNP: rs1501299
rs1501299
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE None of the other 10 SNPs were associated with T2DM in this study, although rs2241766 and rs1501299 were reported to be associated with T2DM in previous Chinese studies. 19631916

2009

dbSNP: rs1501299
rs1501299
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Together, our data support that the rs2241766 and rs1501299 polymorphisms within the ADIPOQ gene confer genetic susceptibility for type 2 diabetes, especially in the Chinese Han population. 25135112

2014

dbSNP: rs16861194
rs16861194
Diabetes Mellitus, Non-Insulin-Dependent
0.050 GeneticVariation BEFREE Varied association of ADIPOQ genotypes with T2DM was seen according to the genetic model used: rs17300539 and rs266729 were significantly associated with T2DM under the three models, while rs16861194 was association with T2DM under additive and dominant models, and rs822396, rs2241766, and rs1063538 were associated with T2DM under the dominant models only. 22497971

2012

dbSNP: rs16861194
rs16861194
Diabetes Mellitus, Non-Insulin-Dependent
0.050 GeneticVariation BEFREE However, due to the limited sample size, only the rs16861194 exerted a significant increased risk on T2DM. 29101068

2018

dbSNP: rs16861194
rs16861194
Diabetes Mellitus, Non-Insulin-Dependent
0.050 GeneticVariation BEFREE To investigate the contribution of the adiponectin genes and their receptors to T2DM, a case-control study was performed and 11 SNPs of ADIPOQ, ADIPOR1, and ADIPOR2 were genotyped in 985 T2DM and 1,050 control subjects. rs16861194 (-11426 A>G) in the putative promoter of ADIPOQ was associated with T2DM (P = 0.007; OR = 1.29, 95%CI 1.08-1.55). 19631916

2009

dbSNP: rs16861194
rs16861194
Diabetes Mellitus, Non-Insulin-Dependent
0.050 GeneticVariation BEFREE When T2D cohort was further stratified according to the obesity status, PPARγ2 (rs1801282) and FTO (rs9939609) showed association with T2D only in the obese diabetic group and ADIPOQ (rs16861194) showed no difference in risk of susceptibility to the disease. 26243686

2016