|
rs1229984
|
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
GWASCAT |
In the trans-ancestral meta-analysis, rs1229984 was associated with multiple phenotypes and two additional loci were genome-wide significant: rs61826952 (chromosome 1, DSM-IV AD, P = 8.42E-11); rs7597960 (chromosome 2, Time spent drinking, P = 1.22E-08).
|
31090166 |
2019 |
|
rs1229984
|
|
Alcoholic Intoxication, Chronic
|
C |
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
|
30940813 |
2019 |
|
rs1229984
|
|
Alcoholic Intoxication, Chronic
|
C |
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.
|
24166409 |
2014 |
|
rs1229984
|
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
GWASDB |
In case-control analysis, ADH1B rs1229984 (H47R) showed the most significant association with the risk of AD (p = 2.63 × 10(-21), OR = 2.35).
|
23456092 |
2013 |
|
rs1229984
|
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
GWASCAT |
In case-control analysis, ADH1B rs1229984 (H47R) showed the most significant association with the risk of AD (p = 2.63 × 10(-21), OR = 2.35).
|
23456092 |
2013 |
|
rs671
|
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
GWASCAT |
When rs671 was considered as a candidate SNP in females, it explained 23.6% of the variation in flushing response, but alcohol consumption rates were too low among females-despite familial enrichment for AD-for an adequate test of association for either AD or maximum drinks.
|
24277619 |
2014 |
|
rs671
|
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
GWASDB |
When rs671 was considered as a candidate SNP in females, it explained 23.6% of the variation in flushing response, but alcohol consumption rates were too low among females-despite familial enrichment for AD-for an adequate test of association for either AD or maximum drinks.
|
24277619 |
2014 |
|
rs1789891
|
|
Alcoholic Intoxication, Chronic
|
A |
0.820 |
GeneticVariation
|
GWASCAT |
Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis.
|
28714907 |
2017 |
|
rs1789891
|
|
Alcoholic Intoxication, Chronic
|
|
0.820 |
GeneticVariation
|
GWASDB |
Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.
|
22004471 |
2012 |
|
rs1789891
|
|
Alcoholic Intoxication, Chronic
|
|
0.820 |
GeneticVariation
|
GWASCAT |
Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.
|
22004471 |
2012 |
|
rs750338
|
|
Alcoholic Intoxication, Chronic
|
C |
0.810 |
GeneticVariation
|
GWASDB |
The top hit of PKNOX2 (rs750338 with p=1.47 × 10(-6)) in the meta-analysis was replicated with the Australian Twin-Family Study of 778 families (p=1.39 × 10(-2)) Furthermore, several flanking SNPs of the top hits in the meta-analysis demonstrated borderline associations with alcohol dependence in the family sample (top SNPs were rs2269655, rs856613, and rs10496768 with p=4.58 × 10(-3), 2.1 × 10(-4), and 2.86 × 10(-3) for KIAA0040, NRD1 and THSD7B, respectively).
|
21703634 |
2011 |
|
rs750338
|
|
Alcoholic Intoxication, Chronic
|
C |
0.810 |
GeneticVariation
|
GWASCAT |
The top hit of PKNOX2 (rs750338 with p=1.47 × 10(-6)) in the meta-analysis was replicated with the Australian Twin-Family Study of 778 families (p=1.39 × 10(-2)) Furthermore, several flanking SNPs of the top hits in the meta-analysis demonstrated borderline associations with alcohol dependence in the family sample (top SNPs were rs2269655, rs856613, and rs10496768 with p=4.58 × 10(-3), 2.1 × 10(-4), and 2.86 × 10(-3) for KIAA0040, NRD1 and THSD7B, respectively).
|
21703634 |
2011 |
|
rs1000579
|
|
Alcoholic Intoxication, Chronic
|
G |
0.800 |
GeneticVariation
|
GWASCAT |
Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis.
|
28714907 |
2017 |
|
rs1000579
|
|
Alcoholic Intoxication, Chronic
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.
|
22004471 |
2012 |
|
rs1000579
|
|
Alcoholic Intoxication, Chronic
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.
|
22004471 |
2012 |
|
rs2835872
|
|
Alcoholic Intoxication, Chronic
|
G |
0.800 |
GeneticVariation
|
GWASDB |
Family-based genome-wide association study of frontal θ oscillations identifies potassium channel gene KCNJ6.
|
22554406 |
2012 |
|
rs2835872
|
|
Alcoholic Intoxication, Chronic
|
G |
0.800 |
GeneticVariation
|
GWASCAT |
Family-based genome-wide association study of frontal θ oscillations identifies potassium channel gene KCNJ6.
|
22554406 |
2012 |
|
rs4478858
|
|
Alcoholic Intoxication, Chronic
|
G |
0.800 |
GeneticVariation
|
GWASDB |
NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent.
|
23455491 |
2013 |
|
rs4478858
|
|
Alcoholic Intoxication, Chronic
|
G |
0.800 |
GeneticVariation
|
GWASCAT |
NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent.
|
23455491 |
2013 |
|
rs6701037
|
|
Alcoholic Intoxication, Chronic
|
C |
0.800 |
GeneticVariation
|
GWASCAT |
A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.
|
21703634 |
2011 |
|
rs6701037
|
|
Alcoholic Intoxication, Chronic
|
C |
0.800 |
GeneticVariation
|
GWASDB |
A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.
|
21703634 |
2011 |
|
rs6777876
|
|
Alcoholic Intoxication, Chronic
|
G |
0.800 |
GeneticVariation
|
GWASCAT |
Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.
|
21314694 |
2011 |
|
rs6777876
|
|
Alcoholic Intoxication, Chronic
|
G |
0.800 |
GeneticVariation
|
GWASDB |
Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.
|
21314694 |
2011 |
|
rs7590720
|
|
Alcoholic Intoxication, Chronic
|
G |
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association study of alcohol dependence.
|
19581569 |
2009 |
|
rs7590720
|
|
Alcoholic Intoxication, Chronic
|
G |
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of alcohol dependence.
|
19581569 |
2009 |