|
rs110419
|
|
Neuroblastoma
|
|
0.850 |
GeneticVariation
|
BEFREE |
Our findings revealed that rs110419 and rs2168101 polymorphisms were significantly associated with a decreased risk of NB in all genetic models.
|
31830377 |
2020 |
|
rs110419
|
|
Neuroblastoma
|
|
0.850 |
GeneticVariation
|
BEFREE |
<b>Results:</b> Significant associations with neuroblastoma risk were found for four (rs110419, rs4758051, rs10840002, and rs2168101) out of the five polymorphisms.
|
30406033 |
2018 |
|
rs110419
|
|
Neuroblastoma
|
|
0.850 |
GeneticVariation
|
BEFREE |
We also confirmed that rs6939340 A>G (G versus A: OR=1.30, 95% CI=1.13-1.50) and rs110419 G>A (A versus G: OR=1.37, 95% CI=1.19-1.58) were associated with increased neur</span>oblastoma risk for all subjects.
|
29024823 |
2017 |
|
rs110419
|
|
Neuroblastoma
|
|
0.850 |
GeneticVariation
|
BEFREE |
We found that the rs110419 A > G polymorphism was associated with a significantly decreased neuroblastoma</span> risk (AG vs. AA: adjusted OR = 0.65, 95% CI = 0.47-0.91; GG vs. AA: adjusted OR = 0.58, 95% CI = 0.36-0.91; AG/GG vs. AA: adjusted OR = 0.63, 95% CI = 0.46-0.86), and the protective effect was more predominant in children of age > 18 months, males, subgroups with tumor in adrenal gland and mediastinum, and patients in clinical stages III/IV.
|
27009839 |
2016 |
|
rs110419
|
|
Neuroblastoma
|
|
0.850 |
GeneticVariation
|
BEFREE |
A major haplotype, ATC, containing rs204926, rs110420, and rs110419, conferred a significant increase in risk for NB (OR = 1.82, 95% CI: 1.41-2.36, adjusted P < 0.001).
|
26030754 |
2015 |
|
rs6939340
|
|
Neuroblastoma
|
|
0.840 |
GeneticVariation
|
BEFREE |
We also confirmed that rs6939340 A>G (G versus A: OR=1.30, 95% CI=1.13-1.50) and rs110419 G>A (A versus G: OR=1.37, 95% CI=1.19-1.58) were associated with increased neur</span>oblastoma risk for all subjects.
|
29024823 |
2017 |
|
rs6939340
|
|
Neuroblastoma
|
|
0.840 |
GeneticVariation
|
BEFREE |
In the Henan population, only the rs6939340 G>A variant homozygote AA was associated with decreased neuroblastoma risk [AA vs. GG: adjusted odds ratio (OR) = 0.47, 95% confidence interval (CI) = 0.23-0.98; <i>P</i>=0.045].
|
29207648 |
2017 |
|
rs6939340
|
|
Neuroblastoma
|
|
0.840 |
GeneticVariation
|
BEFREE |
We found that the rs6939340 A allele carriers were associated with significantly decreased neuroblastoma susceptibility (AG vs. GG: adjusted OR = 0.54, 95 % CI = 0.38-0.77; AA vs. GG: adjusted OR = 0.49, 95 % CI = 0.25-0.93; and AA/AG vs. GG: adjusted OR = 0.53, 95 % CI = 0.38-0.74) after adjustment for age and gender.
|
26307394 |
2016 |
|
rs6939340
|
|
Neuroblastoma
|
|
0.840 |
GeneticVariation
|
BEFREE |
Homozygosity for the at-risk G allele of the most significantly associated SNP, rs6939340, resulted in an increased likelihood of the development of neuroblastoma (odds ratio, 1.97; 95% confidence interval, 1.58 to 2.45).
|
18463370 |
2008 |
|
rs4712653
|
|
Neuroblastoma
|
|
0.830 |
GeneticVariation
|
BEFREE |
In this case-control study, we analyzed the association between three single nucleotide polymorphisms (SNPs) in the <i>CASC15</i> gene (rs6939340 A>G, rs4712653 T>C, and rs9295536 C>A) and neuroblastoma susceptibility in the Guangdong and Henan populations of China.
|
29207648 |
2017 |
|
rs4712653
|
|
Neuroblastoma
|
|
0.830 |
GeneticVariation
|
BEFREE |
We confirmed that CASC15 rs6939340 A>G, rs4712653 T>C, rs9295536 C>A, LIN28B rs221634 A>T, and LMO1 rs110419 A>G were associated with significantly altered neuroblastoma susceptibility.
|
29024823 |
2017 |
|
rs4712653
|
|
Neuroblastoma
|
|
0.830 |
GeneticVariation
|
BEFREE |
The protective association between variant allele and neuroblastoma susceptibility was also observed for the rs4712653 and rs9295536 polymorphisms.
|
26307394 |
2016 |
|
rs6435862
|
|
Neuroblastoma
|
|
0.830 |
GeneticVariation
|
BEFREE |
After adjusted gender and age, seven out of eleven SNPs in <i>BARD1</i> were significant associated with the risk of NB, including one SNP in 5'-UTR (rs17489363 G > A), two SNPs in exon (rs2229571 G > C and rs3738888 C > T), and four SNPs in intron (rs3768716 A > G, rs6435862 T > G, rs3768707 C > T and rs17487792 C > T).
|
31258718 |
2019 |
|
rs6435862
|
|
Neuroblastoma
|
|
0.830 |
GeneticVariation
|
BEFREE |
However, stratified analysis showed a more profound association between neuroblastoma risk and rs6435862 TG/GG variant genotypes among older children (adjusted OR=1.55, 95% CI=1.04-2.31), and children with adrenal gland-originated disease (adjusted OR=2.94, 95% CI=1.40-6.18), or with ISSN clinical stages III+IV disease (adjusted OR=1.75, 95% CI=1.09-2.84).
|
26941572 |
2016 |
|
rs6435862
|
|
Neuroblastoma
|
|
0.830 |
GeneticVariation
|
BEFREE |
All NB susceptibility genes replicated in the Italian dataset except for DDX4 and IL31RA, and the most significant SNP was rs6435862 in BARD1 (P = 8.4 × 10(-15)).
|
23222812 |
2013 |
|
rs9295536
|
|
Neuroblastoma
|
|
0.830 |
GeneticVariation
|
BEFREE |
We confirmed that CASC15 rs6939340 A>G, rs4712653 T>C, rs9295536 C>A, LIN28B rs221634 A>T, and LMO1 rs110419 A>G were associated with significantly altered neuroblastoma susceptibility.
|
29024823 |
2017 |
|
rs9295536
|
|
Neuroblastoma
|
|
0.830 |
GeneticVariation
|
BEFREE |
In this case-control study, we analyzed the association between three single nucleotide polymorphisms (SNPs) in the <i>CASC15</i> gene (rs6939340 A>G, rs4712653 T>C, and rs9295536 C>A) and neuroblastoma susceptibility in the Guangdong and Henan populations of China.
|
29207648 |
2017 |
|
rs9295536
|
|
Neuroblastoma
|
|
0.830 |
GeneticVariation
|
BEFREE |
The protective association between variant allele and neuroblastoma susceptibility was also observed for the rs4712653 and rs9295536 polymorphisms.
|
26307394 |
2016 |
|
rs3768716
|
|
Neuroblastoma
|
|
0.820 |
GeneticVariation
|
BEFREE |
After adjusted gender and age, seven out of eleven SNPs in <i>BARD1</i> were significant associated with the risk of NB, including one SNP in 5'-UTR (rs17489363 G > A), two SNPs in exon (rs2229571 G > C and rs3738888 C > T), and four SNPs in intron (rs3768716 A > G, rs6435862 T > G, rs3768707 C > T and rs17487792 C > T).
|
31258718 |
2019 |
|
rs3768716
|
|
Neuroblastoma
|
|
0.820 |
GeneticVariation
|
BEFREE |
Our results suggest that the BARD1 rs6435862 T>G and rs3768716 A>G polymorphisms may contribute to increased susceptibility to neuroblastoma, especially for the subjects at age ≥12 months, with adrenal gland-originated or with late clinical stage neuroblastoma.
|
26941572 |
2016 |
|
rs11037575
|
|
Neuroblastoma
|
|
0.810 |
GeneticVariation
|
BEFREE |
In conclusion, we verified that the <i>HSD17B12</i> rs11037575 T allele might negatively associate with neuroblastoma risk.
|
28435286 |
2017 |
|
rs17065417
|
|
Neuroblastoma
|
|
0.810 |
GeneticVariation
|
BEFREE |
Expression of LIN28B and let-7 miRNA correlated with rs17065417 genotype in neuroblastoma cell lines, and we observed significant growth inhibition upon depletion of LIN28B, specifically in neuroblastoma cells that were homozygous for the risk allele.
|
22941191 |
2012 |
|
rs17487792
|
|
Neuroblastoma
|
|
0.810 |
GeneticVariation
|
BEFREE |
After adjusted gender and age, seven out of eleven SNPs in <i>BARD1</i> were significant associated with the risk of NB, including one SNP in 5'-UTR (rs17489363 G > A), two SNPs in exon (rs2229571 G > C and rs3738888 C > T), and four SNPs in intron (rs3768716 A > G, rs6435862 T > G, rs3768707 C > T and rs17487792 C > T).
|
31258718 |
2019 |
|
rs2168101
|
|
Neuroblastoma
|
|
0.730 |
GeneticVariation
|
BEFREE |
Our findings revealed that rs110419 and rs2168101 polymorphisms were significantly associated with a decreased risk of NB in all genetic models.
|
31830377 |
2020 |
|
rs2168101
|
|
Neuroblastoma
|
|
0.730 |
GeneticVariation
|
BEFREE |
In summary, the current study confirmed that the potentially functional <i>LMO1</i> rs2168101 G>T and rs3750952 G>C polymorphisms were associated with neuroblastoma susceptibility.
|
29760797 |
2018 |