|
rs401681
|
|
Malignant neoplasm of pancreas
|
|
0.740 |
GeneticVariation
|
BEFREE |
A small number of common susceptibility loci have been identified for pancreatic cancer, one of which is marked by rs401681 in the TERT-CLPTM1L gene region on chromosome 5p15.33.
|
25940397 |
2015 |
|
rs401681
|
|
Malignant neoplasm of pancreas
|
|
0.740 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that T allele of CLPTM1L-telomerase reverse transcriptase rs401681 polymorphism is associated with an increased PC risk, especially among Chinese.
|
25284078 |
2015 |
|
rs401681
|
|
Malignant neoplasm of pancreas
|
|
0.740 |
GeneticVariation
|
BEFREE |
Our data suggests that the T allele of rs401681 in CLPTM1L-TERT locus predisposes its carriers to pancreatic cancer, and further research into the function of CLPTM1L-TERT locus and its potential biological mechanism association may be warranted.
|
24577890 |
2014 |
|
rs401681
|
|
Malignant neoplasm of pancreas
|
|
0.740 |
GeneticVariation
|
BEFREE |
These findings suggested that rs401681 C allele was a low-penetrance risk allele for the development of cancers of lung, bladder, prostate and basal cell carcinoma, but a potential protective allele for melanoma and pancreatic cancer.
|
23226346 |
2012 |
|
rs505922
|
|
Malignant neoplasm of pancreas
|
|
0.740 |
GeneticVariation
|
BEFREE |
This study provided evidence of SNP rs505922 C allele as a strong risk factor of cancer susceptibility, specifically for pancreatic cancer.
|
25656610 |
2015 |
|
rs505922
|
|
Malignant neoplasm of pancreas
|
|
0.740 |
GeneticVariation
|
BEFREE |
SNP rs505922, located within the first intron of the ABO gene, has been associated with the adenocarcinoma subtype of pancreatic cancer.
|
22642827 |
2012 |
|
rs505922
|
|
Malignant neoplasm of pancreas
|
|
0.740 |
GeneticVariation
|
BEFREE |
Consistent with earlier reports showing a higher risk of PC for individuals with the non-O blood type, the previously reported protective allele (T) for rs505922 was found to be strongly correlated (r(2) = 0.96) with the O allele.
|
21306478 |
2011 |
|
rs505922
|
|
Malignant neoplasm of pancreas
|
|
0.740 |
GeneticVariation
|
BEFREE |
We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28).
|
19648918 |
2009 |
|
rs3790844
|
|
Malignant neoplasm of pancreas
|
|
0.730 |
GeneticVariation
|
BEFREE |
Our results showed that the rs3790843 (GA vs GG: OR=0.86, CI=0.76-0.98, <i>P</i>=0.992; GA+AA vs GG: OR=0.83, CI=0.73-0.94, <i>P</i>=0.950; A vs G: OR=0.85, CI=0.78-0.93, <i>P</i>=0.802), rs3790844 (CC vs TT: OR=0.65, CI=0.54-0.78, <i>P</i>=0.617; CC vs TT+CT: OR=0.73, CI=0.62-0.85, <i>P</i>=0.742; C vs T: OR=0.78, CI=0.73-0.84, <i>P</i>=0.555) and rs12029406 (TT vs CC: OR=0.73, CI=0.61-0.89, <i>P</i>=0.483; TT vs CC+CT: OR=0.78, CI=0.66-0.92, <i>P</i>=0.648; T vs C: OR=0.87, CI=0.79-0.95, <i>P</i>=0.837) polymorphisms were associated statistically with the risk of pancreatic cancer.
|
29785120 |
2018 |
|
rs3790844
|
|
Malignant neoplasm of pancreas
|
|
0.730 |
GeneticVariation
|
BEFREE |
In previously reported pancreatic cancer-associated SNPs, rs3790844 (NR5A2) showed a significant correlation with PDAC in our cohort.
|
28639428 |
2018 |
|
rs3790844
|
|
Malignant neoplasm of pancreas
|
|
0.730 |
GeneticVariation
|
BEFREE |
Our case-control study found that rs3790843 and rs3790844 in the NR5A2 gene are associated with pancreatic cancer risk in Japanese subjects.
|
26592175 |
2015 |
|
rs13181
|
|
Malignant neoplasm of pancreas
|
|
0.060 |
GeneticVariation
|
BEFREE |
In addition, haplotype analysis revealed that haplotype AGG, which comprised rs13181, rs3916874 and rs238415, was associated with a 1.401-fold increase in pancreatic cancer risk (p < 0.05).
|
29260835 |
2019 |
|
rs13181
|
|
Malignant neoplasm of pancreas
|
|
0.060 |
GeneticVariation
|
BEFREE |
The present meta-analysis showed significant associations between deoxyribonucleic acid (DNA) repair gene (X-ray repair cross-complementing group 1 (XRCC1) Arg399GIn and Arg194Trp, excision repair cross complementation 1 (ERCC1) rs11615 and rs3212986, ERCC2 rs13181) polymorphisms and PC risk.
|
31393355 |
2019 |
|
rs13181
|
|
Malignant neoplasm of pancreas
|
|
0.060 |
GeneticVariation
|
BEFREE |
Association between ERCC2 Lys751Gln polymorphism and the risk of pancreatic cancer, especially among Asians: evidence from a meta-analysis.
|
28223548 |
2017 |
|
rs13181
|
|
Malignant neoplasm of pancreas
|
|
0.060 |
GeneticVariation
|
BEFREE |
However, no significant difference was found between the ERCC2 rs13181 polymorphism and the risk of pancreatic cancer in the codominant, dominant, and recessive models.
|
27051038 |
2016 |
|
rs13181
|
|
Malignant neoplasm of pancreas
|
|
0.060 |
GeneticVariation
|
BEFREE |
The increasing evidence of XPD-Lys751Gln impact on the outcome of gemcitabine-cisplatin-based polychemotherapy leads to plan prospective studies to validate the role of this polymorphism as a new tool for optimization of the currently available treatments in pancreatic cancer.
|
23390054 |
2013 |
|
rs13181
|
|
Malignant neoplasm of pancreas
|
|
0.060 |
GeneticVariation
|
BEFREE |
The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk.
|
16458430 |
2007 |
|
rs1799782
|
|
Malignant neoplasm of pancreas
|
|
0.060 |
GeneticVariation
|
BEFREE |
The present meta-analysis showed significant associations between deoxyribonucleic acid (DNA) repair gene (X-ray repair cross-complementing group 1 (XRCC1) Arg399GIn and Arg194Trp, excision repair cross complementation 1 (ERCC1) rs11615 and rs3212986, ERCC2 rs13181) polymorphisms and PC risk.
|
31393355 |
2019 |
|
rs1799782
|
|
Malignant neoplasm of pancreas
|
|
0.060 |
GeneticVariation
|
BEFREE |
This study examined the main and interactive effect of 9 single-nucleotide polymorphisms (SNPs) (Arg194Trp, Arg280His, Arg399Gln, c.1254C>T, c.1517G>C, c.1471G>A, C310T, 539del542, and T1915C) of XRCC1 in contribution to pancreatic cancer (PC).
|
26418909 |
2016 |
|
rs1799782
|
|
Malignant neoplasm of pancreas
|
|
0.060 |
GeneticVariation
|
BEFREE |
In conclusion, we found that XRCC1 Arg399Gln genetic variations are associated with pancreatic cancer development, whereas the XRCC1 Arg280His and Arg194Trp polymorphisms did not affect pancreatic cancer risk.
|
27323136 |
2016 |
|
rs1799782
|
|
Malignant neoplasm of pancreas
|
|
0.060 |
GeneticVariation
|
BEFREE |
In the subgroup analysis based on ethnicity, there was no statistically significant association between XRCC1 rs1799782 genetic polymorphism and pancreatic cancer risk in Asians/Caucasians under all genetic models (all P values > 0.05).
|
24435745 |
2014 |
|
rs1799782
|
|
Malignant neoplasm of pancreas
|
|
0.060 |
GeneticVariation
|
BEFREE |
Yet only one polymorphism, XRCC1 Arg194Trp, appears to be involved in smoking-related cancers and in early onset pancreatic cancer.
|
17397816 |
2007 |
|
rs1799782
|
|
Malignant neoplasm of pancreas
|
|
0.060 |
GeneticVariation
|
BEFREE |
We investigated the association between polymorphisms of MGMT (Leu(84)Phe and Ile(143)Val), APE1 (Asp(148)Glu), and XRCC1 (Arg(194)Trp and Arg(399)Gln) and risk of pancreatic cancer in a case-control study.
|
16844323 |
2006 |
|
rs1217691063
|
|
Malignant neoplasm of pancreas
|
|
0.050 |
GeneticVariation
|
BEFREE |
MTHFR gene C677T rather than A1298C polymorphism may be associated with PC.
|
31701291 |
2020 |
|
rs1217691063
|
|
Malignant neoplasm of pancreas
|
|
0.050 |
GeneticVariation
|
BEFREE |
We performed a meta-analysis of all relevant case-control studies that examined the association between MTHFR C677T polymorphism and pancreatic cancer risk.
|
23098468 |
2012 |