rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
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BEFREE |
Specific mutations of RAF kinases, such as the prevalent BRAF(V600E) mutation in melanoma, or defects in upstream signaling or feedback loops cause decoupled kinase activities which lead to tumorigenesis.
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28466200 |
2019 |
rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
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BEFREE |
According to the literature, our data provide evidence of the BRAF and RAS roles in thyroid tumorigenesis, supporting an association between BRAF (V600E) mutations and the more aggressive clinical and pathological features of thyroid tumors.
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29435002 |
2018 |
rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
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BEFREE |
Mutation in the B RAF at V600E has been well implicated in the carcinogenesis that makes it as an attractive therapeutictarget.
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28472910 |
2017 |
rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
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BEFREE |
Specifically, both the initial and recurrent tumors of the patient showed the same BRAF V600E mutation, which refutes previous suggestions that BRAF mutations may be limited to intracranial PXAs and also shows that BRAF mutations may occur earlier in PXA tumorigenesis.
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27956254 |
2017 |
rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
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BEFREE |
Interesting, Prof. Peng Hou and colleagues, at the First Affiliated Hospital of Xi'an Jiaotong University in China, identified unknown epigenetic mechanisms and their involvement in the tumorigenesis of B-RAF(V600E)-driven cancer.
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28638488 |
2017 |
rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
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BEFREE |
The data suggest that coexpression of BRAF(V600E) and KRAS(G12D) in early tumorigenesis leads to negative selection due to oncogene-induced senescence.
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26028035 |
2016 |
rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
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BEFREE |
The coexistence of LCH and ECD in the same biopsy and the BRAF (V600E) mutation status in both histologic types support the recent re-classification of the histiocytic disorder into LCH, ECD, and "mixed histiocytosis", which reflects tumorigenesis for all three from a common progenitor cell.
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26466952 |
2016 |
rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
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BEFREE |
The proliferation and tumorigenesis in V600E melanoma were decrease after CPT1A knockdown.
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27793752 |
2016 |
rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
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BEFREE |
While the role of BRAF(V600E) in tumorigenesis is well established, its involvement in metastasis that is clinically observed in melanoma patients remains a topic of debate.
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27210749 |
2016 |
rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
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BEFREE |
Here, we studied the expression and function of the exportin cellular apoptosis susceptibility (CAS) in thyroid carcinogenesis and its link to the BRAF(V600E) mutation.
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26892809 |
2016 |
rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
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BEFREE |
To understand how oncogenic B-Raf contributes to carcinogenesis, in particular to aspects other than cellular proliferation and survival, we generated three isogenic human colorectal carcinoma cell line models in which we can dynamically modulate the expression of the B-Raf(V600E) oncoprotein.
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25381152 |
2015 |
rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
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BEFREE |
Further analyses suggested a complex mechanism driven by mutation BRAF (V600E) on melanoma tumorigenesis that disturbs specific cancer-related genes, pathways, and methylation modifications.
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25890285 |
2015 |
rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
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BEFREE |
A large number of studies in the past decade have tried to dissect the relevance and the function of the V600E mutation in controlling oncogenesis and progression of thyroid cancer.
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24828987 |
2015 |
rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
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BEFREE |
Therefore, these data indicate that PRDX1 and PRDX6 expression not only may play a key role in papillary thyroid carcinogenesis via a BRAF V600E-dependent mechanism, but their determination could be considered as potential tumor marker for indicating tumor progression in PTCs, independently of BRAF status.
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24316730 |
2014 |
rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
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BEFREE |
Here we show decreasing the levels of CTR1 (Cu transporter 1), or mutations in MEK1 that disrupt Cu binding, decreased BRAF(V600E)-driven signalling and tumorigenesis in mice and human cell settings.
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24717435 |
2014 |
rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
|
BEFREE |
BRAF(V600E) mutation is an early event in thyroid carcinogenesis, and is associated with distinctive morphology and aggressive features even in papillary thyroid microcarcinomas.
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22918165 |
2013 |
rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
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BEFREE |
We propose that continuously activated BRAF(V600E) signaling may be a possible mechanism for the deregulation of Mps1 stability and kinase activity in human tumors, and that persistent phosphorylation of Mps1 through BRAF(V600E) signaling is a key event in disrupting the control of centrosome duplication and chromosome stability that may contribute to tumorigenesis.
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22430208 |
2013 |
rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
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BEFREE |
The prevalence (90%) of the BRAF (V600E) mutation in this study is the highest ever reported, confirming the key role of this mutation in PTC tumorigenesis.
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23179992 |
2013 |
rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
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BEFREE |
Here, we report that Mps1/AKT and B-Raf(WT)/ERK signaling form an auto-regulatory negative feedback loop in melanoma cells; notably, oncogenic B-Raf(V600E) abrogates the negative feedback loop, contributing the aberrant Mps1 functions and tumorigenesis.
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23726842 |
2013 |
rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
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BEFREE |
This is the first report of BRAF V600E mutation in endometrial cancer, indicating that it may contribute to tumorigenesis of endometrial cancer, although at a low frequency compared with KRAS mutations.
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23370429 |
2013 |
rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
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BEFREE |
The presence of BRAF V600E and mitogen-activated protein kinase activation in a largely benign tumor supports the necessity for secondary events (e.g., p16 loss) in BRAF-driven oncogenesis.
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22727996 |
2012 |
rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
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BEFREE |
We have thus uncovered a previously unrecognized prominent epigenetic mechanism in the tumorigenesis of melanoma driven by BRAF(V600E).
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22189819 |
2012 |
rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
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BEFREE |
We combined (L597V)Braf with (G12D)Kras and found that (L597V)Braf modified (G12D)Kras oncogenesis such that fibroblast transformation and lung tumor development were more reminiscent of that driven by the high-activity (V600E)Braf mutant.
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22892241 |
2012 |
rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
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BEFREE |
Here we report that BRAF(V600E) expression in neural progenitors (NPs) is insufficient for tumorigenesis and increases NP cellular differentiation as well as apoptosis.
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22586120 |
2012 |
rs113488022
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Carcinogenesis
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0.100 |
GeneticVariation
|
BEFREE |
The high frequency of methylation and BRAF V600E mutation suggests that many signet ring cell carcinomas may be related to the serrated pathway of carcinogenesis.
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22522845 |
2012 |