rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Overall, none associations between the allelic variants of rs10993994 polymorphisms with whole and PC aggressiveness were found.
|
30774776 |
2019 |
rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
This study demonstrated a significant association between the MSMB rs10993994 polymorphisms and PCa risk.
|
31773691 |
2019 |
rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our data indicated that MSMB gene rs10993994 polymorphism was associated with an increased risk of PC.
|
28212531 |
2017 |
rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Rs11672691 and rs10993994 were associated with both fatal and nonfatal PCa, while rs6465657, rs7127900, rs2735839, and rs13385191 were associated with nonfatal PCa only.
|
24411283 |
2014 |
rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
BACKGROUND.With recent advances in high-throughput sequencing technologies, many prostate cancer risk loci have been identified, including rs10993994, a single nucleotide polymorphism (SNP) located near the MSMB gene.
|
24464504 |
2014 |
rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
These data indicate that the increase in PC risk associated with rs10993994:C>T is likely mediated by the variant's effect on PSP94 expression; however, this effect does not extend to NCOA4 in the data presented here.
|
22887727 |
2013 |
rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Regardless of race and ethnicity or rs10993994 genotype, men with low blood levels of MSP have increased risk of prostate cancer.
|
23213189 |
2013 |
rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The rs10993994 genotype in the MSMB gene modifies the association between number of sexual partners and PCa risk.
|
24037734 |
2013 |
rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Association of prostate cancer susceptibility variant (MSMB) rs10993994 with risk of spermatogenic failure.
|
23608167 |
2013 |
rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Six markers associated with early-onset prostate cancer [rs2171492 (7q32), rs6983561 (8q24), rs10993994 (10q11), rs4430796 (17q12), rs1799950 (17q21), and rs266849 (19q13)] were genotyped.
|
22144497 |
2012 |
rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
After allowing for multiple testing, none of the SNPs examined were significantly associated with growth factor or hormone concentrations, and the SNP-prostate cancer associations did not differ by these concentrations, although 4 interactions were marginally significant (MSMB-rs10993994 with androstenedione (uncorrected P = 0.008); CTBP2-rs4962416 with IGFBP-3 (uncorrected P = 0.003); 11q13.2-rs12418451 with IGF-1 (uncorrected P = 0.006); and 11q13.2-rs10896449 with SHBG (uncorrected P = 0.005)).
|
22459122 |
2012 |
rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Cells with prostate cancer risk alleles at rs10993994 seem to cope more efficiently with DNA double strand breaks (less MN) in a shorter time (decreased MD index).
|
22677538 |
2012 |
rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
PCa susceptibility was associated with TT genotype of SNP rs10993994 in this cohort of Scottish men and the increased risk of PCa was modified by serum enterolactone concentrations.
|
22733159 |
2012 |
rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Of note, rs7000448 is in strong linkage disequilibrium with rs10761581 in NCOA4, a SNP that has been implicated to be independently associated, with respect to the widely reported SNP rs10993994 in the nearby gene MSMB, with prostate cancer in men of European descent.
|
20717903 |
2011 |
rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our results suggest a mechanism by which rs10993994 might predispose to prostate cancer and raise the possibility that genetic variation might need to be considered in interpreting the levels of these biomarkers.
|
20696662 |
2010 |
rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
rs10993994 in MSMB promoter affects serum MSMB expression, contributes to the genetic predisposition to prostate cancer in southern Chinese Han population.
|
20333697 |
2010 |
rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Genome-wide association studies (GWAS) have established a variant, rs10993994, on chromosome 10q11 as being associated with prostate cancer risk.
|
21085629 |
2010 |
rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine.
|
20967219 |
2010 |
rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We examined the association between rs10993994 genotype and MSP levels in a sample of 500 prostate cancer-free men from four racial/ethnic populations in the Multiethnic Cohort (European Americans, African Americans, Latinos, and Japanese Americans).
|
20736317 |
2010 |
rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
SNP rs10993994 is 2 bp upstream of the transcription initiation site of MSMB and was identified as an associated PrCa risk variant.
|
19997100 |
2010 |
rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
For the two SNPs that had significant differences between more and less aggressive disease rs2735839 in KLK3 (P = 8.4 x 10(-7)) and rs10993994 in MSMB (P = 0.046), the alleles that are associated with increased risk for PCa were more frequent in patients with less aggressive disease.
|
19434657 |
2009 |
rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, in a small case-control study of prostate cancer cases from Utah high-risk pedigrees, we have significantly replicated association of prostate cancer with rs10993994</span> (10q11) upon study-wide correction for multiple comparisons.
|
19336566 |
2009 |
rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, loci associated with risk for prostate cancer, such as rs7920517 and rs10993994, might also be used to predict the recurrence of prostate-specific antigen in prostate cancer patients receiving radical prostatectomy.
|
19900942 |
2009 |
rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Recent functional work has shown that different alleles of the significantly associated SNP in the promoter of MSMB found to be associated with prostate cancer risk, rs10993994, can influence its expression in tumors and in vitro studies.
|
19644707 |
2009 |
rs10993994
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Further investigation is warranted to determine whether rs10993994 alone or in combination with additional variants contributes to prostate cancer susceptibility.
|
19383797 |
2009 |