rs55770810
|
|
Malignant neoplasm of ovary
|
A |
0.800 |
CausalMutation
|
CLINVAR |
|
|
|
rs55770810
|
|
Malignant neoplasm of ovary
|
|
0.800 |
GeneticVariation
|
UNIPROT |
|
|
|
rs28897672
|
|
Malignant neoplasm of ovary
|
|
0.730 |
GeneticVariation
|
BEFREE |
We identified a founder mutation (4153delA, 5382insC or C61G) in 6% of 235 unselected cases of breast cancer and in 19% of 43 unselected cases of ovarian cancer.
|
20345474 |
2010 |
rs28897672
|
|
Malignant neoplasm of ovary
|
|
0.730 |
GeneticVariation
|
BEFREE |
While the Cys61Gly mutation appeared underrepresented in ovarian cancer as compared with breast cancer cases from the same population (p = 0.01), the 4153delA mutation made a higher contribution to ovarian cancer than to breast cancer (p < 0.01).
|
20569256 |
2010 |
rs28897672
|
|
Malignant neoplasm of ovary
|
|
0.730 |
GeneticVariation
|
BEFREE |
The risk for breast cancer was 42% higher among first degree relatives of carriers of the C61G missense mutation compared to other mutations (HR = 1.42; p = 0.10) and the risk for ovarian cancer was lower than average (OR = 0.26; p = 0.03).
|
16227521 |
2006 |
rs28897672
|
|
Malignant neoplasm of ovary
|
|
0.730 |
GeneticVariation
|
UNIPROT |
|
|
|
rs1801155
|
|
Malignant neoplasm of ovary
|
|
0.720 |
GeneticVariation
|
BEFREE |
In the Ashkenazi Jewish population, the I1307K allele is unlikely to increase the risk of ovarian cancer or of cancer in general.
|
9679945 |
1998 |
rs1801155
|
|
Malignant neoplasm of ovary
|
|
0.720 |
GeneticVariation
|
BEFREE |
To determine whether the excess of colon cancer in some breast-ovarian cancer families is related to the I1307K mutation, we evaluated 264 Ashkenazi Jews from 158 families.
|
9407954 |
1997 |
rs1801155
|
|
Malignant neoplasm of ovary
|
A |
0.720 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
rs2072590
|
|
Malignant neoplasm of ovary
|
|
0.720 |
GeneticVariation
|
BEFREE |
The OC risk-associated SNP rs2072590 lies in non-coding DNA downstream of <i>HOXD3</i> and upstream of <i>HOXD1</i>, and it tags SNPs in the <i>HOXD3</i> 3' UTR.
|
29262571 |
2017 |
rs2072590
|
|
Malignant neoplasm of ovary
|
|
0.720 |
GeneticVariation
|
GWASDB |
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
|
23535730 |
2013 |
rs2072590
|
|
Malignant neoplasm of ovary
|
|
0.720 |
GeneticVariation
|
BEFREE |
To assess the potential implications of microRNAs in ovarian cancer, we investigated the associations between microRNA expression and seven ovarian cancer risk variants discovered from genome-wide association studies (GWAS), namely, rs3814113 on 9p22.2, rs2072590 on 2q31, rs2665390 on 3q25, rs10088218, rs1516982, rs10098821 on 8q24.21 and rs2363956 on 19p13.
|
22235027 |
2012 |
rs2072590
|
|
Malignant neoplasm of ovary
|
T |
0.720 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.
|
20852632 |
2010 |
rs3814113
|
|
Malignant neoplasm of ovary
|
|
0.720 |
GeneticVariation
|
GWASDB |
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
|
23535730 |
2013 |
rs3814113
|
|
Malignant neoplasm of ovary
|
|
0.720 |
GeneticVariation
|
BEFREE |
To assess the potential implications of microRNAs in ovarian cancer, we investigated the associations between microRNA expression and seven ovarian cancer risk variants discovered from genome-wide association studies (GWAS), namely, rs3814113 on 9p22.2, rs2072590 on 2q31, rs2665390 on 3q25, rs10088218, rs1516982, rs10098821 on 8q24.21 and rs2363956 on 19p13.
|
22235027 |
2012 |
rs3814113
|
|
Malignant neoplasm of ovary
|
|
0.720 |
GeneticVariation
|
BEFREE |
A genome-wide association study recently identified an association between the rare allele of the single-nucleotide polymorphism (SNP) rs3814113 (ie, the C allele) at 9p22.2 and decreased risk of ovarian cancer for women in the general population.
|
21169536 |
2011 |
rs3814113
|
|
Malignant neoplasm of ovary
|
T |
0.720 |
GeneticVariation
|
GWASDB |
The most significant SNP (rs3814113; P = 2.5 x 10(-17)) was genotyped in a further 2,670 ovarian cancer cases and 4,668 controls, confirming its association (combined data odds ratio (OR) = 0.82, 95% confidence interval (CI) 0.79-0.86, P(trend) = 5.1 x 10(-19)).
|
19648919 |
2009 |
rs10088218
|
|
Malignant neoplasm of ovary
|
|
0.710 |
GeneticVariation
|
GWASDB |
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
|
23535730 |
2013 |
rs10088218
|
|
Malignant neoplasm of ovary
|
|
0.710 |
GeneticVariation
|
BEFREE |
To assess the potential implications of microRNAs in ovarian cancer, we investigated the associations between microRNA expression and seven ovarian cancer risk variants discovered from genome-wide association studies (GWAS), namely, rs3814113 on 9p22.2, rs2072590 on 2q31, rs2665390 on 3q25, rs10088218, rs1516982, rs10098821 on 8q24.21 and rs2363956 on 19p13.
|
22235027 |
2012 |
rs10088218
|
|
Malignant neoplasm of ovary
|
G |
0.710 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.
|
20852632 |
2010 |
rs121913279
|
|
Malignant neoplasm of ovary
|
|
0.710 |
GeneticVariation
|
BEFREE |
We also found that an activating (E545K) Pik3ca mutation, unlike Pten inactivation or Pik3ca H1047R mutation, cannot cooperate with Arid1a loss to promote ovarian cancer development in the mouse.
|
26279473 |
2016 |
rs121913279
|
|
Malignant neoplasm of ovary
|
|
0.710 |
GeneticVariation
|
UNIPROT |
Mutation of the PIK3CA gene in ovarian and breast cancer.
|
15520168 |
2004 |
rs17879961
|
|
Malignant neoplasm of ovary
|
|
0.710 |
GeneticVariation
|
BEFREE |
The association between the I157T missense variant was then confirmed in a second sample of Russian patients with borderline ovarian cancers</span> (OR = 2.7; P = 0.06).
|
16828850 |
2006 |
rs17879961
|
|
Malignant neoplasm of ovary
|
G |
0.710 |
GeneticVariation
|
CLINVAR |
|
|
|
rs2363956
|
|
Malignant neoplasm of ovary
|
|
0.710 |
GeneticVariation
|
BEFREE |
To assess the potential implications of microRNAs in ovarian cancer, we investigated the associations between microRNA expression and seven ovarian cancer risk variants discovered from genome-wide association studies (GWAS), namely, rs3814113 on 9p22.2, rs2072590 on 2q31, rs2665390 on 3q25, rs10088218, rs1516982, rs10098821 on 8q24.21 and rs2363956 on 19p13.
|
22235027 |
2012 |