|
rs17401966
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
More well-designed studies with larger sample size and various ethnic groups and risk factors are needed to establish that KIF1B rs17401966 polymorphism is significantly associated with risk of HCC.
|
30947687 |
2019 |
|
rs17401966
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
This meta-analysis suggested that KIF1B (rs17401966) polymorphism could decrease HCC risk in Chinese and in overall population, but not in non-Chinese.
|
29881295 |
2018 |
|
rs17401966
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The gene-environment interaction between the KIF1B rs17401966 variant and alcohol consumption may contribute to the development of HCC in Chinese individuals.
|
27122668 |
2016 |
|
rs17401966
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
This meta-analysis showed a significant association between KIF1B rs17401966 polymorphism and HCC.
|
24952890 |
2014 |
|
rs17401966
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A moderate increase in differentiation was noted for rs2596542 (F st = 0.106) and rs17401966 (F st = 0.116), single nucleotide polymorphisms (SNPs) associated with an increased risk of HCC in patients with chronic HCV and HBV, respectively.
|
24357186 |
2014 |
|
rs17401966
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The SNP rs17401966 was genotyped using the TaqMan allelic discrimination assay in 414 intermediate or advanced hepatocellular carcinoma patients.
|
25153661 |
2014 |
|
rs17401966
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Homozygous mutation of rs1081432 conferred a 2.68-fold risk of HCC (95% CI 1.35-5.34); however heterozygosity was not statistically significant. rs17401966 heterozygosity or homozygosity was not significantly associated with a increased risk of HCC.
|
25412941 |
2014 |
|
rs17401966
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Binary logistic regression showed that rs17401966 was not statistically associated with the risk of HCC development in Thai chronic HBV patients (p-value=0.998, OR=1.00 and 95% CI=0.68-1.48).
|
23803045 |
2013 |
|
rs17401966
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
These findings demonstrate that the presence of the G allele at rs17401966 of the KIF1B gene may decrease the risk for HCC and suggest that KIF1B may play a critical role in the development of HCC.
|
23634229 |
2013 |
|
rs17401966
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
|
23242368 |
2013 |
|
rs17401966
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
None of the replication cohorts showed associations between rs17401966 and HBV-derived HCC.
|
22712471 |
2012 |
|
rs17401966
|
|
Liver carcinoma
|
A |
0.900 |
GeneticVariation
|
GWASDB |
We identified one intronic SNP (rs17401966) in KIF1B on chromosome 1p36.22 that was highly associated with HBV-related HCC and confirmed this association in five additional independent samples, consisting of 1,962 individuals with HCC, 1,430 control subjects and 159 family trios.
|
20676096 |
2010 |
|
rs17401966
|
|
Liver carcinoma
|
A |
0.900 |
GeneticVariation
|
GWASCAT |
We identified one intronic SNP (rs17401966) in KIF1B on chromosome 1p36.22 that was highly associated with HBV-related HCC and confirmed this association in five additional independent samples, consisting of 1,962 individuals with HCC, 1,430 control subjects and 159 family trios.
|
20676096 |
2010 |
|
rs17401966
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
We identified one intronic SNP (rs17401966) in KIF1B on chromosome 1p36.22 that was highly associated with HBV-related HCC and confirmed this association in five additional independent samples, consisting of 1,962 individuals with HCC, 1,430 control subjects and 159 family trios.
|
20676096 |
2010 |
|
rs2596542
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
However, genotype frequencies of rs2596542A/G SNP were statistically different between HCV-induced HCC patients and controls (p = 0.048), and also between HCC and HCV-induced cirrhosis patients (p = 0.039).
|
31471884 |
2019 |
|
rs2596542
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The findings of this meta-analysis suggest that the rs2596542 variant in the MICA promoter region may affect MICA and soluble MICA (sMICA) protein expression, thereby influencing physiological vulnerability to HCC cells and the development of HCC.
|
31419949 |
2019 |
|
rs2596542
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 were identified as being associated with the development of HCV-induced hepatocellular carcinoma (HCC) in Japanese patients.
|
30723271 |
2019 |
|
rs2596542
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Nevertheless, we also detected significant associations between rs259</span>6542G>A and HCV-induced HCC</span>.
|
30967497 |
2019 |
|
rs2596542
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A meta-analysis was performed to examine the association between MICA rs2596542 polymorphism and susceptibility to HCC.
|
30882647 |
2019 |
|
rs2596542
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Taken together our study suggest that MICA rs2596542 SNP impacts HCV-induced HCC susceptibility suggesting that genetic variants in MICA are of clinical relevance to hepatocarcinogenesis by impacting host immune response in chronic HCV infection.
|
31471884 |
2019 |
|
rs2596542
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
We enrolled 787 consecutive patients with chronic HCV infection, which included 174 cases of HCC, and 325 healthy subjects to clarify the involvement of HLA-Bw and C, KIRs, and major histocompatibility complex class I chain-related gene A (MICA) gene polymorphisms (rs2596542 and rs1051792) in chronic HCV infection and HCV-related HCC.
|
29731972 |
2018 |
|
rs2596542
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
These results demonstrate that MICA rs2596542G/G, and particularly the rs2596538C/C polymorphism, are associated with the risk of developing HCV-related HCC in a Sicilian population sample.
|
29584564 |
2018 |
|
rs2596542
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Finally, sMICA levels significantly increased during HCV-related liver disease progression, while a significant relationship between both rs2596542 and rs2596538 genotypes and sMICA plasma levels was identified in patients with LC and HCC.
|
29584564 |
2018 |
|
rs2596542
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, the MICA rs2596542 and DEPDC5 rs1012068 variants in Japanese individuals as well as the HCP5 rs2244546 and PNPLA3 rs738409 variants in European individuals have been found associated with hepatocellular carcinoma (HCC).
|
28928439 |
2017 |
|
rs2596542
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
For cirrhotic non-SVR patients, high sMICA levels (HR/CI: 5·93/1·86–26·38, P = 0·002) [corrected] and the MICA rs2596542 A allele (HR/CI: 4·37/1·52–12·07, P = 0·002) were independently associated with HCC development.
|
27998720 |
2017 |