|
rs1518111
|
|
Behcet Syndrome
|
|
0.830 |
GeneticVariation
|
BEFREE |
Interestingly, we have found, majority of the tribal populations have low frequency of VL ('A' of rs3024498); and high frequency of leprosy ('T' of rs1554286), and Behcet's ('A' of rs1518111) associated alleles, whereas these were vice versa in castes.
|
25941808 |
2015 |
|
rs1518111
|
|
Behcet Syndrome
|
|
0.830 |
GeneticVariation
|
BEFREE |
Similarly, rs1518111, which showed strong linkage disequilibrium (r(2)=1) with allele rs1800871, was also associated with BD (pc=0.026).
|
24269690 |
2014 |
|
rs1518111
|
|
Behcet Syndrome
|
|
0.830 |
GeneticVariation
|
BEFREE |
In IL10, rs1518111 was nominally associated with BD before and after adjustment for population stratification (odds ratio [OR] for T allele 1.20, 95% confidence interval [95% CI] 1.02-1.40, unadjusted P [P(unadj) ] = 2.53 × 10(-2) ; adjusted P [P(adj) ] = 1.43 × 10(-2) ), and rs1554286 demonstrated a trend toward association (P(unadj) = 6.14 × 10(-2) ; P(adj) = 3.21 × 10(-2) ).
|
22378604 |
2012 |
|
rs1518111
|
|
Behcet Syndrome
|
|
0.830 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease.
|
20622878 |
2010 |
|
rs1518111
|
|
Behcet Syndrome
|
|
0.830 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease.
|
20622878 |
2010 |
|
rs1800871
|
|
Behcet Syndrome
|
|
0.830 |
GeneticVariation
|
BEFREE |
Our findings not only confirmed the association of IL10/rs1800871 and IL23R-IL12RB2/rs924080 with BD but also identified 2 susceptibility single nucleotide polymorphisms in IL10 and IL23R-IL12RB2 (rs3024490 and rs12141431) with BD in Han Chinese.
|
27464962 |
2017 |
|
rs1800871
|
|
Behcet Syndrome
|
|
0.830 |
GeneticVariation
|
BEFREE |
Compared to the controls, an increased frequency of the rs1800871 T allele was observed in BD patients with extraocular findings, including genital ulcers, skin lesions, and a positive pathergy test.
|
26015771 |
2015 |
|
rs1800871
|
|
Behcet Syndrome
|
|
0.830 |
GeneticVariation
|
BEFREE |
Similarly, rs1518111, which showed strong</span> linkage disequilibrium (r(2)=1) with allele rs1800871, was also associated with BD (pc=0.026).
|
24269690 |
2014 |
|
rs1800871
|
|
Behcet Syndrome
|
|
0.830 |
GeneticVariation
|
GWASDB |
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
|
23291587 |
2013 |
|
rs1800871
|
|
Behcet Syndrome
|
T |
0.830 |
GeneticVariation
|
GWASDB |
Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.
|
20622879 |
2010 |
|
rs1800871
|
|
Behcet Syndrome
|
T |
0.830 |
GeneticVariation
|
GWASCAT |
Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.
|
20622879 |
2010 |
|
rs3024493
|
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
rs3024493
|
|
Ulcerative Colitis
|
T |
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).
|
20228798 |
2010 |
|
rs3024493
|
|
Ulcerative Colitis
|
T |
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).
|
20228798 |
2010 |
|
rs3024493
|
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
|
19915572 |
2009 |
|
rs3024493
|
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
|
19915572 |
2009 |
|
rs3024493
|
|
Lupus Erythematosus, Systemic
|
|
0.720 |
GeneticVariation
|
BEFREE |
Significant interactions were observed between <i>CD40</i> variant rs48100485 and VCA IgG levels and <i>IL10</i> variant rs3024493 and VCA IgA levels in transitioning to SLE.
|
31217170 |
2019 |
|
rs3024493
|
|
Lupus Erythematosus, Systemic
|
T |
0.720 |
GeneticVariation
|
GWASCAT |
Transancestral mapping and genetic load in systemic lupus erythematosus.
|
28714469 |
2017 |
|
rs3024493
|
|
Lupus Erythematosus, Systemic
|
A |
0.720 |
GeneticVariation
|
GWASCAT |
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.
|
26502338 |
2015 |
|
rs3024493
|
|
Lupus Erythematosus, Systemic
|
|
0.720 |
GeneticVariation
|
BEFREE |
SNP imputation conducted in EA dataset identified three additional SLE-associated SNPs tagged by rs3024505 (rs3122605, rs3024493 and rs3024495 located at 9.2 kb upstream, intron 3 and 4 of IL10, respectively), and SLE-risk alleles of these SNPs were dose-dependently associated with elevated levels of IL10 mRNA in PBMCs and circulating IL-10 protein in SLE patients and controls.
|
24130510 |
2013 |
|
rs3024490
|
|
Behcet Syndrome
|
|
0.710 |
GeneticVariation
|
BEFREE |
Our findings not only confirmed the association of IL10/rs1800871 and IL23R-IL12RB2/rs924080 with BD but also identified 2 susceptibility single nucleotide polymorphisms in IL10 and IL23R-IL12RB2 (rs3024490 and rs12141431) with BD in Han Chinese.
|
27464962 |
2017 |
|
rs3024490
|
|
Behcet Syndrome
|
|
0.710 |
GeneticVariation
|
GWASDB |
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
|
23291587 |
2013 |
|
rs1800871
|
|
Oral Ulcer
|
G |
0.700 |
GeneticVariation
|
GWASCAT |
Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci.
|
30837455 |
2019 |
|
rs1800872
|
|
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO
|
G |
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
|
rs3024493
|
|
Psoriasis
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |