|
rs20417
|
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Here, we evaluate the impact of the four most common cyclooxygenase-2 gene polymorphisms (rs689465, rs689466, rs20417 and rs20417), in combination with obesity, on the risk of breast cancer progression in a cohort of Brazilian breast cancer patients (<i>N</i> = 1038).
|
29321183 |
2018 |
|
rs20417
|
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation
|
BEFREE |
Here, we evaluate the impact of the four most common cyclooxygenase-2 gene polymorphisms (rs689465, rs689466, rs20417 and rs20417), in combination with obesity, on the risk of breast cancer progression in a cohort of Brazilian breast cancer patients (<i>N</i> = 1038).
|
29321183 |
2018 |
|
rs20417
|
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our results indicate no strong association between three most frequent COX-2 SNPs rs689465 rs689466, rs20417 studied with breast cancer risk in the single locus analysis.
|
24789723 |
2015 |
|
rs20417
|
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
COX-2-rs20417 CC genotype was significantly associated with increased risk of breast cancer when comparing to G allele [ORs were 1.231 (1.050-1.444) for CC vs. GG, P = 0.01, 1.223 (1.045-1.432) for CC vs. G carrier, P = 0.01].
|
25433948 |
2015 |
|
rs20417
|
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our results indicate no strong association between three most frequent COX-2 SNPs rs689465 rs689466, rs20417 studied with breast cancer risk in the single locus analysis.
|
24789723 |
2015 |
|
rs20417
|
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation
|
BEFREE |
COX-2-rs20417 CC genotype was significantly associated with increased risk of breast cancer when comparing to G allele [ORs were 1.231 (1.050-1.444) for CC vs. GG, P = 0.01, 1.223 (1.045-1.432) for CC vs. G carrier, P = 0.01].
|
25433948 |
2015 |
|
rs20417
|
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
This meta-analysis showed that COX-2 rs20417 polymorphism was correlated with an increased risk of breast cancer in Caucasians, while rs689466 was associated with a decreased risk of breast cancer in Caucasians.
|
25214704 |
2014 |
|
rs20417
|
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation
|
BEFREE |
This meta-analysis showed that COX-2 rs20417 polymorphism was correlated with an increased risk of breast cancer in Caucasians, while rs689466 was associated with a decreased risk of breast cancer in Caucasians.
|
25214704 |
2014 |
|
rs20417
|
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
In conclusion, the present meta-analysis suggests that none of the most studied three SNPs (rs5275, rs20417, and rs5277) in the COX-2 gene is a conspicuous low-penetrant risk factor for developing breast cancer.
|
20033767 |
2010 |
|
rs20417
|
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation
|
BEFREE |
In conclusion, the present meta-analysis suggests that none of the most studied three SNPs (rs5275, rs20417, and rs5277) in the COX-2 gene is a conspicuous low-penetrant risk factor for developing breast cancer.
|
20033767 |
2010 |
|
rs20417
|
|
Prostate carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association between the cyclooxygenase 2 (COX2) -765G>C (rs20417) polymorphism and prostate cancer (PC) risk using meta-analysis.
|
26535654 |
2015 |
|
rs20417
|
|
Malignant neoplasm of prostate
|
|
0.040 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association between the cyclooxygenase 2 (COX2) -765G>C (rs20417) polymorphism and prostate cancer (PC) risk using meta-analysis.
|
26535654 |
2015 |
|
rs20417
|
|
Prostate carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
When all groups were pooled, we did not detect a significant association of rs20417 polymorphism with prostate cancer risk.
|
22782583 |
2012 |
|
rs20417
|
|
Malignant neoplasm of prostate
|
|
0.040 |
GeneticVariation
|
BEFREE |
When all groups were pooled, we did not detect a significant association of rs20417 polymorphism with prostate cancer risk.
|
22782583 |
2012 |
|
rs20417
|
|
Prostate carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
In a hospital-based case/control study, 195 subjects with PCa and 250 healthy controls were investigated for the association of COX-2 -765 G>C (rs20417) and +8473 T>C (rs5275) promoter polymorphism with PCa susceptibility using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method.
|
22023987 |
2011 |
|
rs20417
|
|
Malignant neoplasm of prostate
|
|
0.040 |
GeneticVariation
|
BEFREE |
In a hospital-based case/control study, 195 subjects with PCa and 250 healthy controls were investigated for the association of COX-2 -765 G>C (rs20417) and +8473 T>C (rs5275) promoter polymorphism with PCa susceptibility using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method.
|
22023987 |
2011 |
|
rs20417
|
|
Malignant neoplasm of prostate
|
|
0.040 |
GeneticVariation
|
BEFREE |
We found no evidence that rs20417</span> alters prostate cancer</span> risk (odds</span> ratio (OR(CC & GC v GG)=1.05, 95% confidence interval (CI)=0.91-1.20).
|
19488068 |
2009 |
|
rs20417
|
|
Prostate carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
We found no evidence that rs20417</span> alters prostate cancer</span> risk (odds</span> ratio (OR(CC & GC v GG)=1.05, 95% confidence interval (CI)=0.91-1.20).
|
19488068 |
2009 |
|
rs5275
|
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Associations between the 8473T>C polymorphism (rs5275) in the cyclooxygenase-2 (COX-2) gene and breast cancer (BC) risk are still inconclusive and ambiguous.
|
25520090 |
2014 |
|
rs5275
|
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
The rs5275 polymorphism had no association with breast cancer risk.
|
25214704 |
2014 |
|
rs5275
|
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The rs5275 polymorphism had no association with breast cancer risk.
|
25214704 |
2014 |
|
rs5275
|
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
Associations between the 8473T>C polymorphism (rs5275) in the cyclooxygenase-2 (COX-2) gene and breast cancer (BC) risk are still inconclusive and ambiguous.
|
25520090 |
2014 |
|
rs5275
|
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association between each polymorphism and breast cancer risk under the codominant model, dominant model, and recessive model, respectively (nine studies with 6,968 cases and 9,126 controls for rs5275; three studies with 2,901 cases and 3,463 controls for rs20417; two studies with 5,551 cases and 6,208 controls for rs5277).
|
20033767 |
2010 |
|
rs5275
|
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association between each polymorphism and breast cancer risk under the codominant model, dominant model, and recessive model, respectively (nine studies with 6,968 cases and 9,126 controls for rs5275; three studies with 2,901 cases and 3,463 controls for rs20417; two studies with 5,551 cases and 6,208 controls for rs5277).
|
20033767 |
2010 |
|
rs5275
|
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
The rs5275 polymorphism in the 3' untranslated region of the PTGS2 gene was associated with a decrease in breast cancer risk.
|
17214885 |
2007 |