|
rs759834365
|
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association between BDNF Val66Met and SI was modeled using logistic regression adjusted for age and sex, and in secondary analyses also for depression.
|
30329132 |
2020 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
Carriage of BDNF Val66Met has been associated with faster cognitive decline and greater hippocampal atrophy in cognitively normal elderly.
|
31771052 |
2020 |
|
rs759834365
|
|
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, we assessed whether the functional single nucleotide polymorphism (SNP) on the BDNF gene, Val66Met, moderated the relationship between depressive symptoms and perceived social support and unsupportive relationships, and whether these associations differed by gender.
|
31364951 |
2020 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association between BDNF Val66Met and SI was modeled using logistic regression adjusted for age and sex, and in secondary analyses also for depression.
|
30329132 |
2020 |
|
rs759834365
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association between BDNF Val66Met and SI was modeled using logistic regression adjusted for age and sex, and in secondary analyses also for depression.
|
30329132 |
2020 |
|
rs759834365
|
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
Fifty-two samples from the depressed patient group were genotyped for the Val66Met BDNF polymorphism.
|
29802070 |
2019 |
|
rs759834365
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF-Val66Met polymorphism may index susceptibility to expression of psychosis along a spectrum.
|
29785763 |
2019 |
|
rs759834365
|
|
Obsessive-Compulsive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Findings from this meta-analytic investigation of published literature provide little support for the Val66Met variant of BDNF as a predictor of OCD.
|
31291217 |
2019 |
|
rs759834365
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Childhood adversity showed an interaction with the brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism, serotonin transporter-linked promoter region (5-HTTLPR), and FK506 binding protein 51 (FKBP5) gene rs1360780 in brain morphologic changes in patients with depression and in a non-clinical population.
|
29535036 |
2019 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that the BDNF Val66Met variant is not associated with response to antipsychotics in individuals with SCZ.
|
30181602 |
2019 |
|
rs759834365
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pattern of cortical thinning associated with the BDNF Val66Met polymorphism in Parkinson's disease.
|
31202861 |
2019 |
|
rs759834365
|
|
Obsessive-Compulsive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Regression analysis determined the extent to which psychiatric comorbidity, illness severity, OCD symptom dimensions, childhood trauma history, and the Val66Met (rs6265) polymorphism of the brainderived neurotrophic factor (BDNF) gene predict lifetime suicidal ideation and attempts in adults with OCD.
|
31046037 |
2019 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our objectives were to: 1) compare plasma BDNF levels in medicated patients with depression and controls; 2) assess the effect of ECT on plasma BDNF levels in medicated patients with depression; 3) explore the relationship between plasma BDNF levels and the Val66Met (rs6265) BDNF polymorphism; and 4) examine the relationship between plasma BDNF levels and clinical symptoms and outcomes with ECT.
|
29802070 |
2019 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
Replication and Meta-analysis of the Association between BDNF Val66Met Polymorphism and Cognitive Impairment in Patients Receiving Chemotherapy.
|
30382534 |
2019 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined whether BDNF Val66Met variation was associated with cognitive impairment in mTLE.
|
29952080 |
2019 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Childhood adversity showed an interaction with the brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism, serotonin transporter-linked promoter region (5-HTTLPR), and FK506 binding protein 51 (FKBP5) gene rs1360780 in brain morphologic changes in patients with depression and in a non-clinical population.
|
29535036 |
2019 |
|
rs759834365
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our objectives were to: 1) compare plasma BDNF levels in medicated patients with depression and controls; 2) assess the effect of ECT on plasma BDNF levels in medicated patients with depression; 3) explore the relationship between plasma BDNF levels and the Val66Met (rs6265) BDNF polymorphism; and 4) examine the relationship between plasma BDNF levels and clinical symptoms and outcomes with ECT.
|
29802070 |
2019 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our analyses suggested the G196A (Val66Met) polymorphism was significantly associated with cog</span>nitive impairment in PD, especially in Caucasian populations.
|
31365694 |
2019 |
|
rs759834365
|
|
Mood Disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
The impact of BDNF Val66Met polymorphism on cognition in Bipolar Disorder: A review: Special Section on "Translational and Neuroscience Studies in Affective Disorders" Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders.
|
30078664 |
2019 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Plasma brain-derived neurotrophic factor (BDNF) concentration and the <i>BDNF</i> Val66Met polymorphism in suicide: a prospective study in patients with depressive disorder.
|
31308724 |
2019 |
|
rs759834365
|
|
Anxiety
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met gene polymorphism is associated with increased alexithymic and anticipatory anxiety in patients with panic disorder.
|
30269521 |
2019 |
|
rs759834365
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met contributed to the severity of CSI even after adjusting to PTSD, depression and LEC.
|
30904785 |
2019 |
|
rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A total of 1,081 adults without dementia (375 healthy subjects and 706 individuals with mild cognitive impairment) were recruited from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to test the influence of BDNF Val66Met polymorphism on cognitive impairment, brain structure atrophy, and change in the levels of CSF biomarkers.
|
30775992 |
2019 |
|
rs759834365
|
|
Mental disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, considering that these parameters are determinant for protein interactions and, consequently, protein function; the alterations observed throughout the MD analyses may be related to the functional impairment of BDNF upon V66M mutation, as well as its involvement in psychiatric disorders.
|
30998730 |
2019 |
|
rs759834365
|
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Val66Met polymorphism did not appear to predict BDNF levels, depression incidence, or modify the relationship between dietary quality and BDNF.
|
29280414 |
2019 |