Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE Few genetic studies exploring the impact of Val66Met on cognition in BD. 30078664

2019

dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach.Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. 28479278

2017

dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE Although the Val66Met polymorphism at the BDNF gene does not seem to play a significant role in children and adolescents with BD or ADHD, BDNF serum levels deserve further attention in future research on neurobiological aspects of BD and ADHD. 27209073

2016

dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE BDNF Val66Met polymorphism and bipolar disorder in European populations: A risk association in case-control, family-based and GWAS studies. 27236043

2016

dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE Previous studies investigated the impact of brain-derived neurotrophic factor (BDNF) val66met (rs6265) on hippocampus volumes and neurocognition in bipolar disorders (BD), but the results were not consistent. 27018938

2016

dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE We concluded that changes in plasma BDNF levels significantly correlated with changes in WCST scores in BD and is moderated by the BDNF Val66Met polymorphism and the subtype of BD. 27905499

2016

dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE Association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism with early-onset bipolar disorder. 26528762

2015

dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE Although the present study has some limitations, the results indicate a lack of association between the Val66Met polymorphism and bipolar disorder</span>. 25041243

2015

dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE We aimed to explore whether anxiety in BD offspring was associated with the BDNF Val66Met polymorphism.64 BD offspring (mean age: 13.73 (S.D. 25498133

2015

dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE Association between brain-derived neurotrophic factor genetic polymorphism Val66Met and susceptibility to bipolar disorder: a meta-analysis. 25539739

2014

dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE Here we investigated a two hit gene environment model in relation to functional genomic factors (BDNF mRNA), and volume of hippocampal subfields in schizophrenia spectrum and bipolar disorders, focusing on both an environmental (childhood trauma) and genetic risk factor (BDNF val66met). 25246365

2014

dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE The BDNF val66met polymorphism is a potential vulnerability factor for cognitive impairment in BD. 24862657

2014

dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia. 24468644

2014

dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE Val66Met polymorphism and serum brain-derived neurotrophic factor in bipolar disorder: an open-label trial. 23957567

2014

dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE Plasma BDNF concentration did not differ by val66met or BD subtype, nor was it correlated with age or illness duration. 24398043

2014

dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE The Val66Met polymorphism at the BDNF gene does not influence Wisconsin Card Sorting Test results in children and adolescents with bipolar disorder. 23567599

2013

dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE Sixty-six subjects with BD (41 in manic and 25 in depressive episodes) and 78 healthy volunteers were genotyped for BDNF Val(66)Met and tested for creativity using the Barrow Welsh Art Scale (BWAS) and neuropsychological tests. 22484201

2012

dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE Further studies are needed to evaluate the genetic association between the val66met allele and the BD-PTSD population, along with central/peripheral BDNF levels and epigenetic patterns of BDNF gene regulation within these patients. 21931317

2012

dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE Our study also adds to the body of evidence associating the functional Val66Met polymorphism of BDNF with BD. 22085476

2012

dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE We examined the association between the BDNF Val66Met and DRD3 Ser9Gly polymorphisms with two subtypes of bipolar disorder: bipolar-I and -II. 22877924

2012

dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE Previous studies have suggested that the Val66Met (also known as rs6265 or G196A) variant of BDNF is associated with bipolar disorder (BPD), but the results have been inconclusive. 19330778

2010

dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE The aim of the present study was to examine the interplay between the BDNF Val(66)Met polymorphism and stressful life events (SLEs) in bipolar disorder. 20172611

2010

dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE Our study suggests that the markers examined thus far in COMT and SLC6A4 are not associated with pediatric bipolar disorder and that if the val66met marker in BDNF is associated with pediatric bipolar disorder the magnitude of the association is much smaller than first reported. 19193231

2009

dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE Changes in gyrification over 4 years in bipolar disorder and their association with the brain-derived neurotrophic factor valine(66) methionine variant. 19167700

2009

dbSNP: rs759834365
rs759834365
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.100 GeneticVariation BEFREE Effects of the brain-derived neurotrophic growth factor val66met variation on hippocampus morphology in bipolar disorder. 18704093

2009