rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Few genetic studies exploring the impact of Val66Met on cognition in BD.
|
30078664 |
2019 |
rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach.Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers.
|
28479278 |
2017 |
rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although the Val66Met polymorphism at the BDNF gene does not seem to play a significant role in children and adolescents with BD or ADHD, BDNF serum levels deserve further attention in future research on neurobiological aspects of BD and ADHD.
|
27209073 |
2016 |
rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met polymorphism and bipolar disorder in European populations: A risk association in case-control, family-based and GWAS studies.
|
27236043 |
2016 |
rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Previous studies investigated the impact of brain-derived neurotrophic factor (BDNF) val66met (rs6265) on hippocampus volumes and neurocognition in bipolar disorders (BD), but the results were not consistent.
|
27018938 |
2016 |
rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We concluded that changes in plasma BDNF levels significantly correlated with changes in WCST scores in BD and is moderated by the BDNF Val66Met polymorphism and the subtype of BD.
|
27905499 |
2016 |
rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism with early-onset bipolar disorder.
|
26528762 |
2015 |
rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although the present study has some limitations, the results indicate a lack of association between the Val66Met polymorphism and bipolar disorder</span>.
|
25041243 |
2015 |
rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We aimed to explore whether anxiety in BD offspring was associated with the BDNF Val66Met polymorphism.64 BD offspring (mean age: 13.73 (S.D.
|
25498133 |
2015 |
rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between brain-derived neurotrophic factor genetic polymorphism Val66Met and susceptibility to bipolar disorder: a meta-analysis.
|
25539739 |
2014 |
rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here we investigated a two hit gene environment model in relation to functional genomic factors (BDNF mRNA), and volume of hippocampal subfields in schizophrenia spectrum and bipolar disorders, focusing on both an environmental (childhood trauma) and genetic risk factor (BDNF val66met).
|
25246365 |
2014 |
rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF val66met polymorphism is a potential vulnerability factor for cognitive impairment in BD.
|
24862657 |
2014 |
rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia.
|
24468644 |
2014 |
rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Val66Met polymorphism and serum brain-derived neurotrophic factor in bipolar disorder: an open-label trial.
|
23957567 |
2014 |
rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Plasma BDNF concentration did not differ by val66met or BD subtype, nor was it correlated with age or illness duration.
|
24398043 |
2014 |
rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Val66Met polymorphism at the BDNF gene does not influence Wisconsin Card Sorting Test results in children and adolescents with bipolar disorder.
|
23567599 |
2013 |
rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Sixty-six subjects with BD (41 in manic and 25 in depressive episodes) and 78 healthy volunteers were genotyped for BDNF Val(66)Met and tested for creativity using the Barrow Welsh Art Scale (BWAS) and neuropsychological tests.
|
22484201 |
2012 |
rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further studies are needed to evaluate the genetic association between the val66met allele and the BD-PTSD population, along with central/peripheral BDNF levels and epigenetic patterns of BDNF gene regulation within these patients.
|
21931317 |
2012 |
rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study also adds to the body of evidence associating the functional Val66Met polymorphism of BDNF with BD.
|
22085476 |
2012 |
rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined the association between the BDNF Val66Met and DRD3 Ser9Gly polymorphisms with two subtypes of bipolar disorder: bipolar-I and -II.
|
22877924 |
2012 |
rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Previous studies have suggested that the Val66Met (also known as rs6265 or G196A) variant of BDNF is associated with bipolar disorder (BPD), but the results have been inconclusive.
|
19330778 |
2010 |
rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the present study was to examine the interplay between the BDNF Val(66)Met polymorphism and stressful life events (SLEs) in bipolar disorder.
|
20172611 |
2010 |
rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study suggests that the markers examined thus far in COMT and SLC6A4 are not associated with pediatric bipolar disorder and that if the val66met marker in BDNF is associated with pediatric bipolar disorder the magnitude of the association is much smaller than first reported.
|
19193231 |
2009 |
rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Changes in gyrification over 4 years in bipolar disorder and their association with the brain-derived neurotrophic factor valine(66) methionine variant.
|
19167700 |
2009 |
rs759834365
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effects of the brain-derived neurotrophic growth factor val66met variation on hippocampus morphology in bipolar disorder.
|
18704093 |
2009 |