Variant | Gene | Disease | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||||
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0.820 | GeneticVariation | BEFREE | We developed a sensitive, simple and rapid approach to detect the low-abundance PIK3CA (H1047R) mutation in real CRC specimens, providing an effective tool for guiding cancer targeted therapy. | 27405731 | 2016 |
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0.820 | GeneticVariation | BEFREE | Collectively, our data suggest that PF-04691502 exhibits potent anticancer activity in colorectal cancer by targeting both PIK3CA (H1047R) mutant CSCs and their derivatives. | 23826249 | 2013 |
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|
0.820 | GeneticVariation | UNIPROT | The prevalence of PIK3CA mutations in gastric and colon cancer. | 15994075 | 2005 |
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|
|
0.820 | GeneticVariation | UNIPROT | Functional analysis of PIK3CA gene mutations in human colorectal cancer. | 15930273 | 2005 |
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|
|
G | 0.820 | CausalMutation | CLINVAR | ||||||||||
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0.800 | GeneticVariation | UNIPROT | Functional analysis of PIK3CA gene mutations in human colorectal cancer. | 15930273 | 2005 |
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|
|
0.800 | GeneticVariation | UNIPROT | The prevalence of PIK3CA mutations in gastric and colon cancer. | 15994075 | 2005 |
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|
A | 0.800 | CausalMutation | CLINVAR | ||||||||||
|
|
0.700 | GeneticVariation | UNIPROT | |||||||||||
|
|
0.700 | GeneticVariation | UNIPROT | |||||||||||
|
|
0.700 | GeneticVariation | UNIPROT | Functional analysis of PIK3CA gene mutations in human colorectal cancer. | 15930273 | 2005 |
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|
|
0.700 | GeneticVariation | UNIPROT | The prevalence of PIK3CA mutations in gastric and colon cancer. | 15994075 | 2005 |
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|
|
0.700 | GeneticVariation | UNIPROT | |||||||||||
|
|
G | 0.700 | CausalMutation | CLINVAR | ||||||||||
|
|
T | 0.700 | CausalMutation | CLINVAR | ||||||||||
|
|
0.700 | GeneticVariation | UNIPROT | |||||||||||
|
|
A | 0.700 | CausalMutation | CLINVAR | ||||||||||
|
|
0.700 | GeneticVariation | UNIPROT | Functional analysis of PIK3CA gene mutations in human colorectal cancer. | 15930273 | 2005 |
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|
|
0.700 | GeneticVariation | UNIPROT | The prevalence of PIK3CA mutations in gastric and colon cancer. | 15994075 | 2005 |
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|
|
0.010 | GeneticVariation | BEFREE | These findings provide evidence that a miR-520a binding site polymorphism rs141178472 in the PIK3CA 3'-UTR may play a role in the etiology of CRC. | 25834816 | 2015 |
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|
0.010 | GeneticVariation | BEFREE | However, no association was detected between rs2699887 in the PIK3CA gene and CRC risk. | 26722535 | 2015 |