Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs762846821
rs762846821
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.030 GeneticVariation BEFREE Autophagy is required for mitochondrial function, lipid metabolism, growth, and fate of KRAS(G12D)-driven lung tumors. 23959381

2013
dbSNP: rs762846821
rs762846821
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.030 GeneticVariation BEFREE We crossed IL-6(-/-) mice with Kras(G12D) mutant mice, which develop lung tumors after activation of mutant Kras(G12D), to investigate whether IL-6 inhibition contributes to tumor progression and survival time in vivo. 24260500

2013
dbSNP: rs762846821
rs762846821
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.030 GeneticVariation BEFREE Conversely, in lung tumour cell lines expressing Kras(G12D) and lacking p53, p53 restoration led to NF-kappaB inhibition. 19847165

2009
dbSNP: rs587782329
rs587782329
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.010 GeneticVariation BEFREE Lung tumors of 50 uranium miners in Germany were screened by restriction fragment length analysis for the putative hotspot mutation at codon 249 (Arg-->Met) previously detected in a significant fraction of miners from the Colorado Plateau, USA. 9067550

1997