|
rs397507444
|
|
Multiple Myeloma
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our objective was to determine the association between the methylenetetrahydrofolate reductase polymorphisms (C677T and A1298C) and the risk of developing acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), acute myeloid leukemia (AML), and multiple myelomas (MM) in Latinos.
|
31188929 |
2019 |
|
rs397507444
|
|
Multiple Myeloma
|
|
0.080 |
GeneticVariation
|
BEFREE |
Overall, no significant association was found between MTHFR A1298C polymorphism and MM risk under all four genetic models (AC vs. AA, OR = 0.99, 95%CI = 0.82-1.20; CC vs. AA, OR = 1.14, 95%CI = 0.77-1.68; recessive model, OR = 1.10, 95%CI = 0.76-1.59; dominant model, OR = 1.01, 95%CI = 0.84-1.22).
|
26022785 |
2015 |
|
rs397507444
|
|
Multiple Myeloma
|
|
0.080 |
GeneticVariation
|
BEFREE |
Case-control studies investigating associations between multiple myeloma (MM) and the C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) have provided controversial results.
|
18350248 |
2008 |
|
rs397507444
|
|
Multiple Myeloma
|
|
0.080 |
GeneticVariation
|
BEFREE |
We tested whether the polymorphisms of the methylenetetrahydrofolate reductase gene, MTHFR C677T and A1298C, the methionine synthase gene, MTR A2756G, the methionine synthase reductase gene, MTRR A66G, and the thymidylate synthase gene, TYMS 2R-->3R, involved in folate and methionine metabolism, altered the risk for multiple myeloma (MM).
|
17655928 |
2008 |
|
rs397507444
|
|
Multiple Myeloma
|
|
0.080 |
GeneticVariation
|
BEFREE |
Moreover, we demonstrated that MTHFR 677CC and 1298CC genotype might have combined effect on risk of CML, AML and MM and it is inferred that the A1298C may play a different role in carcinogenesis, depending on the types of organs involved, the types of disease entities and the genotype of C677T.
|
17156840 |
2007 |
|
rs397507444
|
|
Multiple Myeloma
|
|
0.080 |
GeneticVariation
|
BEFREE |
These results suggest that MTHFR C677T, A1298C, MTRR A66G, TS 2R-->3R, and 6-bp deletion/insertion do not significantly factor into the pathogenesis of MM in the Korean population, but that MS A2756G polymorphism may play an important role.
|
17546637 |
2007 |
|
rs397507444
|
|
Multiple Myeloma
|
|
0.080 |
GeneticVariation
|
BEFREE |
To investigate the influence of two common polymorphisms of MTHFR C677T and A1298C on the risk of multiple myeloma (MM), we performed a matched case-control study.
|
16541270 |
2006 |
|
rs397507444
|
|
Multiple Myeloma
|
|
0.080 |
GeneticVariation
|
BEFREE |
We analysed genetic polymorphisms for methionine synthase (MS) A2756G, methylenetetrahydrofolate reductase (MTHFR) C677T and MTHFR A1298C in Caucasians with non-Hodgkin's lymphoma (NHL; n = 151), multiple myeloma (MM; n = 90) and 299 control subjects.
|
12648076 |
2003 |