|
rs397507444
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genotyping of hyperhomocysteinemia associated MTHFR polymorphisms C677T (rs1801133) and A1298C (rs1801131) was done by PCR-restriction fragment length polymorphism.
|
29600437 |
2018 |
|
rs397507444
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the distribution of MTHFR C677T and A1298C as well as PON1 Q192R gene polymorphisms, known to be involved in hyperhomocysteinemia-related cardiovascular risk, in elite athletes.
|
26282718 |
2016 |
|
rs397507444
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
to investigate if NAFLD, in subjects referred for nutritional assessment and counselling, has any difference of prevalence and severity when associated with isolated MTHFR A1298C polymorphism and hyperhomocysteinemia.
|
24488901 |
2014 |
|
rs397507444
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A thrombophilic evaluation was performed, revealing hyperhomocysteinemia and methylenetetrahydrofolate reductase (MTHFR) variants (C677T and A1298C).
|
24923843 |
2014 |
|
rs397507444
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The methylenetetrahydrofolate reductase (MTHFR) 677C>T and 1298A>C polymorphisms, which are associated with hyperhomocysteinemia and nitric oxide (NO) deficiency (which is related to atherothrombosis and cerebral ischemia), have not been studied in moyamoya disease.
|
25098357 |
2014 |
|
rs397507444
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
All participants had a thrombotic workup that included the following: genetic markers: factor V Leiden G1691A and G20210A prothrombin mutations, methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms; protein assays: protein C, protein S and antithrombin; other tests: blood typing and screening for hyperhomocysteinemia.
|
23337711 |
2013 |
|
rs397507444
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR polymorphisms C677T and A1298C are associated with reduced MTHFR enzyme activity and hyperhomocysteinemia, which has been associated with osteoporosis.
|
22377704 |
2012 |
|
rs397507444
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk factors of diabetic nephropathy in type 2 diabetes patients.
|
16828193 |
2007 |
|
rs397507444
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Finally, we did not find any significant association of combined C677T and A1298C MTHFR polymorphisms with an increased risk for hyperhomocysteinemia in PD patients.
|
17914182 |
2007 |
|
rs397507444
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study confirmed the high prevalence of hyperhomocysteinemia in patients on dialysis, which was diagnosed in 76 patients (85.39%) and high incidence of the C677T and A1298C mutation, 42 (47.19%) and 29 (32.58%) patients, respectively.
|
17966140 |
2007 |
|
rs397507444
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
APS, revealed by anti-beta-2-glycoprotein and anti-prothrombin antibodies positivity, and moderate HHcy related to heterozygous C677T and A1298C point mutations of the MTHFR gene were identified as a possible cause of thrombotic disorder responsible for the widespread presence of cutaneous and cerebral lesions.
|
16595601 |
2006 |
|
rs397507444
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Because they have been described as strong risk factors for idiopathic recurrent pregnancy losses (RPLs), we assessed the association between the methylenetetrahydrofolate reductase (MTHFR) single-nucleotide polymorphisms (SNPs) C677T and A1298C and hyperhomocysteinemia in Tunisian women with idiopathic RPL.
|
16452733 |
2006 |
|
rs397507444
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The objectives of this study were: to determine plasma total homocysteine tHcy levels and the prevalence of hyperhomocysteinemia in children with type 1 diabetes, to determine correlates of plasma tHcy levels with nutritional factor such as serum folic acid and vitamin B12 levels, genetic factors as methylenetetrahydrofolate reductase MTHFR gene polymorphism (C677T and A1298C), to attempt to identify possible dependencies between tHcy and the degree of metabolic control, the duration of the disease and presence of complications, and also to determine the relationship between other coronary risk factors.
|
16401615 |
2006 |
|
rs397507444
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated whether the MTHFR C677T and A1298C polymorphisms contribute to hyperhomocysteinemia and increase the risk factor for stroke.
|
16629766 |
2006 |
|
rs397507444
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was the assessment of hyperhomocysteinemia in patients with IBD and its relation among vitamin B12 and folate levels, and methylenetetrahydrofolate reductase (MTHFR) 677C-->T and 1298A-->C mutations.
|
16262529 |
2005 |
|
rs397507444
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The fact that MTHFR A1298C polymorphism is significantly associated with homocysteine levels, and that the CC genotype is present at a higher frequency in the Indian population, makes it extremely relevant in terms of its potential impact on hyperhomocysteinemia.
|
16244782 |
2005 |
|
rs397507444
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study suggests that both C677T and A1298C MTHFR polymorphisms should be examined when assessing genetic risk factors of hyperhomocysteinemia in epilepsy.
|
15970629 |
2004 |
|
rs397507444
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR A1298C mutation alone and gender were not associated with either hyperhomocysteinemia or increased CVD risk, but the HD patients with homozygotes 1298CC and wild alleles 677CC (677CC/1298CC) have significant increase of tHcy (37.7 +/- 12) and high prevalence of CVD.
|
12187094 |
2002 |
|
rs397507444
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, our study shows that neither MTHFR 677C-->T/1298A-->C genotypes nor hyperhomocysteinemia are independently associated with patient or graft survival following kidney transplantation.
|
11169021 |
2001 |
|
rs397507444
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Mutation A1298C of methylenetetrahydrofolate reductase: risk for early coronary disease not associated with hyperhomocysteinemia.
|
11343335 |
2001 |
|
rs397507444
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We also analysed the possible implication of a second new MTHFR polymorphism (1298A-->C) in subjects with mild hyperhomocysteinaemia (4th quartile of homocysteinaemia; tHcy >11.1 micromol/l).
|
11177206 |
2000 |