Variant Gene Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2075650
rs2075650
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.860 GeneticVariation BEFREE CONCLUSIONS" Results from the meta-analysis revealed that the pooled ABCA7 rs376465, CD33 rs3865444, TOMM40 rs157580, and rs2075650 variants were significantly associated with the susceptibility to AD. 26795201

2016

dbSNP: rs2075650
rs2075650
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.860 GeneticVariation BEFREE In single-SNP based tests, AD risk allele of APOE (rs2075650) was associated with smaller HV (p = 0.0054) and CD33 (rs3865444) with smaller intracranial volume (p = 0.0058). 25670335

2016

dbSNP: rs2075650
rs2075650
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.860 GeneticVariation BEFREE The incident case study comparing patients who developed AD during longitudinal observation (n = 152) with participants with no cognitive impairment found that rs2075650 (TOMM40) and rs3865444 (CD33) influence the risk of developing AD in this population. 24176626

2014

dbSNP: rs2075650
rs2075650
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.860 GeneticVariation BEFREE Three SNPs [rs429358 in APOE: odds ratio (OR)=4.24, 95% confidence interval (CI)=3.01-5.96, P=1.23×10; rs2075650 in APOE: OR=3.57, 95% CI=2.51-5.06, P=1.23×10; and rs677909 in PICALM: OR=0.63, 95% CI=0.49-0.81, P=0.00036, log additive model] were significantly associated with AD susceptibility after correction for multiple testing. 22975751

2014

dbSNP: rs2075650
rs2075650
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.860 GeneticVariation BEFREE There were four significant associations between genotypes and phenotypes of AD patients: CR1 SNP rs11803956 correlated with Mini-Mental State Examination (MMSE) score (β=1.718, Pcorrected=0.002); ABCA7 SNP rs3752232 correlated with Rey Complex Figure Test (RCFT) copy score (β=-6.861, Pcorrected=0.013); APOE SNP rs2075650 correlated with the percentile of RCFT copy score (β=14.005, Pcorrected=0.021) and the percentile of total score in phonemic fluency (β=11.052, Pcorrected=0.035). 24530172

2014

dbSNP: rs2075650
rs2075650
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.860 GeneticVariation BEFREE Only TOMM40 rs2075650 showed association with clinical AD after adjusting for APOE-ε4 (p = 0.007), but not after multiple test correction (p>0.05). 23573206

2013