rs6656401
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Three genotypes significantly associated with reduced AD risk relative to PART in the PENN (<i>N</i> = 377) and NACC (<i>N</i> = 1189) cohorts including <i>APOE ε</i>4, <i>APOE ε</i>2, and rs6656401 in the <i>CR1</i> gene.
|
30128317 |
2018 |
rs6656401
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Altogether, five loci (rs6656401 at CR1, rs983392within MS4A6A, rs11218343 at SORL1, rs6733839 at BIN1, and APOE ε4) have been detected to be associated with one or a few established AD-related neuroimaging measures.
|
26732597 |
2017 |
rs6656401
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our analysis further supports previous findings that the CR1 rs6656401 polymorphism contributes to AD susceptibility.
|
24878768 |
2015 |
rs6656401
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our prevalent case study comparing prevalent AD cases (n = 428) with participants with no cognitive impairment (n = 524) revealed a significant association of rs6656401 and rs3818361 (CR1), rs2075650 (TOMM40), rs7561528 (BIN1), and rs3865444 (CD33) with late-onset AD that were robust to adjustment with age and apolipoprotein E ε4 genotype.
|
24176626 |
2014 |
rs6656401
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We investigated the influence of the rs6656401 single nucleotide polymorphisms (SNP) of the CR1 gene, the rs3851179 SNP of the PICALM gene, and the rs11136000 SNP of the CLU gene on risk of AD in a Polish population.
|
23650005 |
2013 |
rs6656401
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
It did not explain (part of) the association of genome wide association top single-nucleotide polymorphisms rs3818361/rs6656401, nor of the CR1 CNV, with AD in our cohort, whereas the CR1 CNV and rs3818361/rs6656401 represented the same association signal.
|
23582656 |
2013 |
rs6656401
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Using 1709 subjects (697 deceased) from the Religious Orders Study and the Rush Memory and Aging Project, we tested 41 single-nucleotide polymorphisms (SNPs) within the linkage disequilibrium block containing the published CR1 AD SNP (rs6656401) for associations with episodic memory decline, and then examined the functional consequences of the top result.
|
22343410 |
2012 |
rs6656401
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Accumulated evidence suggests that a variant within the CR1 gene (single nucleotide polymorphism rs6656401), known to increase risk for Alzheimer disease (AD), influences β-amyloid (Aβ) deposition in brain tissue.
|
22262751 |
2012 |
rs6656401
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Here, we show that two Alzheimer's disease-associated CR1 variants, rs6656401 and rs3818361, are associated with major recurrent depression in females in a population-based cohort using individuals from the Generation Scotland: Scottish Family Health Study.
|
22244847 |
2012 |
rs6656401
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Gene-brain structure associations of 3 recently discovered risk genes for Alzheimer's disease, CLU (rs11136000C>T), CR1 (rs6656401G>A), and PICALM (rs3851179G>A), were investigated in 2 independent cohorts of young healthy adults (n = 430 and n = 492, respectively).
|
21726919 |
2011 |
rs6656401
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A recent large genome-wide association study (GWAS) has identified significant association of two single nucleotide polymorphisms (SNPs) (rs6656401 and rs3818361) in the CR1 gene with AD in Caucasians.
|
20558149 |
2010 |