rs744373
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Post-mortem and in vitro studies suggest that BIN1-associated AD risk is mediated by increased tau pathology but whether rs744373 is associated with increased tau pathology in vivo is unknown.
|
30992433 |
2019 |
rs744373
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The aim of this study was to examine whether the variants of some candidate genes involved in the development of AD, namely BIN1 (rs744373), CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179), are related to several disorders of glucose metabolism-gestational diabetes (GDM), T2DM and impaired glucose tolerance (IGT).
|
28316001 |
2017 |
rs744373
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Mutants in rs1800587 of IL-1A, rs1143634 of IL-1B, rs12989701, and rs744373 of BIN1 were significantly associated with AD onset.
|
26768592 |
2017 |
rs744373
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The Bridging Integrator 1 Gene Polymorphism rs744373 and the Risk of Alzheimer's Disease in Caucasian and Asian Populations: An Updated Meta-Analysis.
|
26846281 |
2017 |
rs744373
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In this case-control study, we aimed to investigate whether single nucleotide polymorphisms in the BIN1 (rs744373) and IL-6 (rs1800795) genes are associated with AD.
|
26733302 |
2016 |
rs744373
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The association between rs3851179 (PICALM), rs744373 (BIN1), and AD was further confirmed by meta-analysis of Asian populations.
|
25452228 |
2016 |
rs744373
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In a subsequent promoter analysis, we found the single nucleotide polymorphism rs744373 C-allele to be associated with high mRNA levels of bridging integrator 1 (BIN1)/Amphiphysin 2, i.e. a major component of the endocytotic machinery and located in a crucial genetic AD risk locus.
|
26631617 |
2016 |
rs744373
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our findings demonstrate that rs744373 itself or a variation in linkage disequilibrium may provide a neurogenetic mechanism for BIN1 while further validating the possibility of combining genetic and neuroimaging strategies to monitor individuals at risk for AD.
|
25630570 |
2015 |
rs744373
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
To our knowledge, this is the first study to show significant association between rs744373 polymorphism and AD in East Asian population.
|
23570733 |
2013 |
rs744373
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In a total of 2816 AD cases and 2706 controls, we unambiguously replicated the association of rs744373 (for BIN1) and rs541458 (for PICALM) polymorphisms with the AD risk (odds ratio [OR] = 1.26, 95% confidence interval [CI] [1.15-1.38], p = 2.9 × 10(-7), and OR = 0.80, 95% CI [0.74-0.88], p = 4.6 × 10(-7), respectively).
|
21220176 |
2011 |