Source: BEFREE

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE The BDNF Val66Met gene polymorphism is associated with increased alexithymic and anticipatory anxiety in patients with panic disorder. 30269521

2019

dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE Interactive genetic association with anxiety was observed such that effects of 5-HTTLPR depended on the BDNF Val66Met polymorphism (rs6265 variant), with higher anxiety scores in short and Met carriers compared to the other allelic groups. 30711709

2019

dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE The aim of the present case-control study was to explore the association between BDNF Val66Met (rs6265) polymorphism and generalized anxiety disorder in Mexican individuals, and whether this polymorphism plays a role in the symptomatology of anxiety.A total of 212 subjects were included in the study. 30882674

2019

dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE Effect of Early-Life Fluoxetine on Anxiety-Like Behaviors in BDNF Val66Met Mice. 29084453

2017

dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE On the contrary, BDNF met allele carriers showed a reduced acoustic startle response which reached significance in most samples (N1: p=0.004; N2: p=0.045; N3: n.s., N4: p=0.043) pointing to differential effects of BDNF val(66)met on distinct endophenotypes of anxiety and stress-related responses. 26773399

2016

dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE Here we comprehensively review the role and relevance of the Val66Met polymorphism in psychiatric disorders, with emphasis on suicidal behavior and anxiety, eating, mood and psychotic disorders. 25824305

2015

dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes. 25640836

2015

dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE BDNF Val66Met, stress, and positive mothering: Differential susceptibility model of adolescent trait anxiety. 26119141

2015

dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE We aimed to explore whether anxiety in BD offspring was associated with the BDNF Val66Met polymorphism.64 BD offspring (mean age: 13.73 (S.D. 25498133

2015

dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE We investigated the effect of brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism on the severity of depressive and anxiety symptoms in never-smokers, former smokers, non-dependent, and nicotine-dependent smokers with a current diagnosis of depression and/or anxiety. 25618300

2015

dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE The Association of BDNF Val66Met Polymorphism With Trait Anxiety in Panic Disorder. 26037856

2014

dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE In this work, we review the literature focused on the BDNF Val(66)Met polymorphism and anxiety, and discuss biological findings from animal models to clinical studies. 24051499

2013

dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE Gender-specific effects of brain-derived neurotrophic factor Val66Met polymorphism and childhood maltreatment on anxiety. 23221871

2013

dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE Because the Val/Val genotype of the BDNF Val66Met polymorphism, rather than the other two polymorphisms, has been associated with anxiety, it seems to affect BP-I comorbid with AD without the involvement of the DRD3 Seg9Gly polymorphism, but may modify the involvement of DRD3 Gly/Gly in BP-II comorbid with AD. 24021960

2013

dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE Gray matter volume in adolescent anxiety: an impact of the brain-derived neurotrophic factor Val(66)Met polymorphism? 23357445

2013

dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE In line with recent studies investigating the role of BDNF Val66Met and DRD2/ANKK1 Taq IA polymorphisms on anxiety and gray matter volume in the ACC, our findings provide the first evidence for a genetic contribution to alexithymia. 21097659

2011

dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE BDNF Val66Met polymorphism is associated with higher anticipatory cortisol stress response, anxiety, and alcohol consumption in healthy adults. 21596481

2011

dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE Our results support the a priori hypothesis of an association between anxiety and the polymorphism Val66Met. 21839144

2011

dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE A polymorphism of the human Brain Derived Neurotrophic Factor (BDNF) gene that produces a valine-to-methionine substitution at codon 66 (Val66Met) is linked to adult anxiety and mood disorders, possibly through effects on brain circuitry function. 19931400

2010

dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE A common polymorphism of the brain-derived neurotrophic factor (BDNF) gene (Val66Met) has been implicated in anxiety, which is associated with lower vagal activity. 20213725

2010

dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE The BDNF Val66Met polymorphism and anxiety: support for animal knock-in studies from a genetic association study in humans. 20478625

2010

dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety. 19153574

2009

dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder. 19582565

2009

dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-derived neurotrophic factor (BDNF Val66Met) genes have been implicated in the neurobiology of anxiety and depression. 17941097

2008

dbSNP: rs759834365
rs759834365
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation BEFREE Assuming that BDNF may be implicated in the putative common pathophysiology of depression and anxiety, we analyzed the association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C > T (formerly named C270T) in the noncoding region of exon V and 196G > A (val66met) in the coding region of exon XIIIA, with panic disorder. 15913870

2005