Although for rs11614913 and rs3746444 polymorphisms, overall analyses suggested negative results, for rs11614913 polymorphism, when subgroup analysis was conducted by cancer type, a significantly decreased risk of renal cell cancer was identified in recessive model.
We found that CT (miR-196a2, C>T rs11614913) was a risk factor for renal cell carcinoma (CT vs. CC: OR = 1.72, 95%CI = 1.05-2.80, <i>P</i> = 0.03, <i>I</i><sup>2</sup> = 66%), especially in Asian population (CT vs. CC: OR = 1.17, 95%CI = 1.04-1.32, <i>P</i> < 0.01, <i>I</i><sup>2</sup> = 0%). miR-146a G>C rs2910164 was a protective factor of urological cancers (C vs. G: OR = 0.87, 95%CI = 0.81-0.93, <i>P</i> < 0.01, <i>I</i><sup>2</sup> = 0%), especially for bladder cancer. miR-499 A>G rs3746444 was correlated with an increased risk of urological cancers, specifically in Asian population.
These results suggested that the miR-196a2rs11614913 may contribute to the genetic susceptibility and prognosis for RCC, which may act as a biomarker for RCC occurrence and prognosis.