Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs132770
rs132770
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma
0.030 GeneticVariation BEFREE Sensitivity analyses were also performed.The rs2267437 polymorphism was associated with a significant increase in risks of overall cancers, breast cancer, renal cell carcinoma and hepatocellular carcinoma, and it could increase the cancer risk in Asian population; the rs5751129 polymorphism could increase the cancer risk in overall cancers; the rs132770 polymorphism was associated with the increased renal cell carcinoma risk; furthermore, the rs132793 polymorphism could decrease breast cancer risk and increase risks in "other cancers".Overall, the results provided evidences that the single nucleotide polymorphisms in XRCC6 promoter region might play different roles in various cancers, indicating different cancers have different tumorigenesis mechanisms. 25569644

2015

dbSNP: rs132770
rs132770
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma
0.030 GeneticVariation BEFREE We hypothesized that the Ku70 A-31G polymorphism (rs132770) was associated with the risk of renal cell carcinoma (RCC). 22455395

2012

dbSNP: rs132770
rs132770
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma
0.030 GeneticVariation BEFREE In a hospital-based case-control study of 92 patients with RCC and 580 cancer-free controls, the frequency matched by age and sex, the associations of XRCC6 promoter T-991C (rs5751129), promoter G-57C (rs2267437), promoter A-31G (rs132770), and intron 3 (rs132774) polymorphisms with RCC risk were investigated in a Taiwanese population. 22993329

2012