Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1048943
rs1048943
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 GeneticVariation BEFREE A semi-quantitative food frequency questionnaire was used to assess the dietary intake of six flavonoid subclasses (flavonols, flavones, flavanones, flavan-3-ols, anthocyanidins, and isoflavones) in 923 patients with colorectal cancer and 1,846 controls; furthermore, CYP1A1 genetic variants (rs4646903 and rs1048943) were genotyped. 28273931

2017

dbSNP: rs1048943
rs1048943
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 GeneticVariation BEFREE Stratification analysis showed the association between rs1048943 A > G and CRC risk was more obvious in studies with the population-based (PB) design or high quality score. 27384991

2016

dbSNP: rs1048943
rs1048943
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 GeneticVariation BEFREE Only CYP1A1 Ile462Val was statistically significant in CRC patients over 50 years old: OR 2.05 (1.29-3.28); p = 1.25E-02 and this association was more pronounced in the female group of CRC patients after the age of 50: OR 2.72 (1.43-5.14); p = 1.14E-02. 24939416

2014

dbSNP: rs1048943
rs1048943
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 GeneticVariation BEFREE CYP1A1 Ile462Val may be an increased risk factor for colorectal cancer. 21246002

2011

dbSNP: rs1048943
rs1048943
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 GeneticVariation BEFREE This study examined interaction effect between smoking and two single nucleotide polymorphisms (SNPs)-CYP1A1 c.1384A>G (p.Ile462Val) and EPHX1 c.337T>C (p.Tyr113His)-in modulating colorectal cancer (CRC) risk. 20886582

2010

dbSNP: rs1048943
rs1048943
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 GeneticVariation BEFREE Our results suggest that the I462V and Msp1 polymorphisms in CYP1A1 may be an additional susceptibility factor for disease expression in Lynch syndrome because they modify the age of colorectal cancer onset by up to 4 years. 18768509

2008

dbSNP: rs1048943
rs1048943
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 GeneticVariation BEFREE Relationship between genetic polymorphism of CYP1A1 at codon 462 (Ile462Val) in colorectal cancer. 18409146

2008