Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1800629
rs1800629
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.040 GeneticVariation BEFREE TNF-α-G308A (rs1800629) polymorphisms are associated with gastric cancer in Chinese population. 27373488

2017

dbSNP: rs1800629
rs1800629
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.040 GeneticVariation BEFREE The goal of this study was to evaluate the influence that polymorphisms in the cytokine genes known as TNF-α-308 G/A (rs1800629), TNF-α-857 C/T (rs1799724), IL-8-251 T/A (rs4073), IL-8-845 T/C (rs2227532), and IL-10-592 C/A (rs1800872) have on changes to mRNA expression levels and on the risks of chronic gastritis (CG) and gastric cancer (GC). 26088449

2015

dbSNP: rs1800629
rs1800629
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.040 GeneticVariation BEFREE The meta-analysis suggests that TNF-α rs1800629 polymorphism is associated with the increased risk of gastric cancer in Caucasians. 24142527

2014

dbSNP: rs1800629
rs1800629
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.040 GeneticVariation BEFREE Statistical analysis results showed significant association of SNPs rs9344, rs1799931, and rs1800629 with the risk of gastric cancer. 23072573

2013

dbSNP: rs1799724
rs1799724
LTA ; TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.020 GeneticVariation BEFREE However, subtype-specific associations were observed for gastric cardia adenocarcinomas at MUC1/TRIM46/1q22 rs2070803 [HRAA versus GA+GG = 2.16; 95% confidence interval (CI) = 1.24-3.78; P = 0.0068] and LTA/TNF/6p21.33 rs1799724 (HRTT+CT versus CC = 1.30; 95% CI = 1.07-1.57; P = 0.0077), and for diffuse-type GC at PSCA/8q24.3 rs2294008 (HRTT versus CT+CC = 1.99; 95% CI = 1.33-2.97; P = 7.8E-04). 29028942

2017

dbSNP: rs1799724
rs1799724
LTA ; TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.020 GeneticVariation BEFREE The goal of this study was to evaluate the influence that polymorphisms in the cytokine genes known as TNF-α-308 G/A (rs1800629), TNF-α-857 C/T (rs1799724), IL-8-251 T/A (rs4073), IL-8-845 T/C (rs2227532), and IL-10-592 C/A (rs1800872) have on changes to mRNA expression levels and on the risks of chronic gastritis (CG) and gastric cancer (GC). 26088449

2015

dbSNP: rs361525
rs361525
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.020 GeneticVariation BEFREE Relationship Between Tumor Necrosis Factor-α rs361525 Polymorphism and Gastric Cancer Risk: A Meta-Analysis. 29867530

2018

dbSNP: rs361525
rs361525
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.020 GeneticVariation BEFREE Associations of TNF-α-308 (rs1800629) and -238 (rs361525) with gastric cancer had the inconsistent indication among different populations. 27373488

2017

dbSNP: rs1799964
rs1799964
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.010 GeneticVariation BEFREE The study results revealed that IL-1β rs1143627: T > C, rs16944: C > T (p = 0.001;OR = 1.85; 95% CI 1.30-2.63) and rs1143633: G > A (p < 0.0001; OR = 2.53; 95% CI 1.67-3.83) and TNF-α rs1800630: C > A, rs1799964: T > C (p < 0.0001; OR = 2.31; 95% CI 1.54-3.46) polymorphisms significantly contributed toward GC risk. 30094865

2018

dbSNP: rs1800630
rs1800630
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.010 GeneticVariation BEFREE The study results revealed that IL-1β rs1143627: T > C, rs16944: C > T (p = 0.001;OR = 1.85; 95% CI 1.30-2.63) and rs1143633: G > A (p < 0.0001; OR = 2.53; 95% CI 1.67-3.83) and TNF-α rs1800630: C > A, rs1799964: T > C (p < 0.0001; OR = 2.31; 95% CI 1.54-3.46) polymorphisms significantly contributed toward GC risk. 30094865

2018