rs759834365
|
|
Post-Traumatic Stress Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study examined the interaction effect of childhood trauma and brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on PTSD symptoms and brain cortical thickness.
|
30988377 |
2019 |
rs759834365
|
|
Post-Traumatic Stress Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we examined the relationship between the BDNF Val66Met polymorphism and PTSD symptoms in two nationally representative samples of European American U.S. military veterans (main sample, n = 1386; replication sample, n = 509).
|
30388593 |
2019 |
rs759834365
|
|
Post-Traumatic Stress Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism moderated the relationship between PTSD and fear extinction learning, such that poorer fear extinction learning was associated with greater PTSD symptom severity (and PTSD diagnostic status) in individuals with the low-expression Met allele, but no relationship was demonstrated in individuals with the Val-Val allele.
|
29550677 |
2018 |
rs759834365
|
|
Post-Traumatic Stress Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results, controlled for the critical covariates, revealed that <i>BDNF</i> Val66Met and C270T were not significantly associated with metabolic indices in veterans with PTSD and that these genetic variants do not contribute to susceptibility to metabolic disturbances in PTSD.
|
30542302 |
2018 |
rs759834365
|
|
Post-Traumatic Stress Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Val66met may impact PTSD susceptibility differentially via enhanced threat sensitivity and HPA axis dysregulation.
|
29649711 |
2018 |
rs759834365
|
|
Post-Traumatic Stress Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Findings from this meta-analytic investigation of the published literature provide little support for the Val66Met variant of BDNF as a predictor of PTSD.
|
29874672 |
2017 |
rs759834365
|
|
Post-Traumatic Stress Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Neither BDNF Val66Met genotype nor plasma BDNF was significantly associated with the presence or severity of ASD or PTSD.
|
26999419 |
2016 |
rs759834365
|
|
Post-Traumatic Stress Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Reduced severity of posttraumatic stress disorder associated with Val allele of Val66Met polymorphism at brain-derived neurotrophic factor gene among Chinese adolescents after Wenchuan earthquake.
|
26751724 |
2016 |
rs759834365
|
|
Post-Traumatic Stress Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Vietnam veterans (n = 257) screened for PTSD and controlled for trauma exposure were genotyped for BDNF Val66Met.
|
27413557 |
2016 |
rs759834365
|
|
Post-Traumatic Stress Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis suggested no genetic association of BDNF Val66Met with vulnerability to PTSD.
|
25925851 |
2015 |
rs759834365
|
|
Post-Traumatic Stress Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study provides the first evidence that the BDNF Val66Met genotype predicts response to cognitive behavior therapy in PTSD and is in accord with evidence that BDNF facilitates extinction learning.
|
23312562 |
2013 |
rs759834365
|
|
Post-Traumatic Stress Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study provides preliminary evidence for an epistatic interaction between BDNF Val66Met and DRD2 Taq1A polymorphisms on the severity of PTSD symptoms, where both too little and too much dopamine can result in increased PTSD symptom severity.
|
23103549 |
2013 |
rs759834365
|
|
Post-Traumatic Stress Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The study shows that veterans with psychotic PTSD carried more Met alleles of the BDNF Val66Met than non-psychotic veterans with PTSD or veterans without PTSD.
|
21728904 |
2012 |
rs759834365
|
|
Post-Traumatic Stress Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further studies are needed to evaluate the genetic association between the val66met allele and the BD-PTSD population, along with central/peripheral BDNF levels and epigenetic patterns of BDNF gene regulation within these patients.
|
21931317 |
2012 |
rs759834365
|
|
Post-Traumatic Stress Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The objective of the present study was to identify, in a case-control study, whether the brain-derived neurotrophic factor (BDNF) val66met polymorphism (rs6265), the dopamine transporter (DAT1) three prime untranslated region (3'UTR) variable number of tandem repeats (VNTR), and the serotonin transporter (5-HTTPRL) short/long variants are associated with the development of PTSD in a group of victims of urban violence.
|
21491204 |
2011 |
rs759834365
|
|
Post-Traumatic Stress Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this paper is to review the available knowledge on the BDNF Val66Met SNP, with emphasis on anxiety- and fear-related endophenotypes and its potential implications for PTSD.
|
20955337 |
2010 |
rs759834365
|
|
Post-Traumatic Stress Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
This variant and two previously reported BDNF SNPs (C270T and Val66Met) were genotyped in 295 patients with AD, 108 with AFDs, 96 with posttraumatic stress disorder (PTSD), 84 with schizophrenia, 327 with alcohol and/or drug dependence, and 250 normal control subjects.
|
16649215 |
2006 |