|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
Carriage of BDNF Val66Met has been associated with faster cognitive decline and greater hippocampal atrophy in cognitively normal elderly.
|
31771052 |
2020 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
Replication and Meta-analysis of the Association between BDNF Val66Met Polymorphism and Cognitive Impairment in Patients Receiving Chemotherapy.
|
30382534 |
2019 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined whether BDNF Val66Met variation was associated with cognitive impairment in mTLE.
|
29952080 |
2019 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our analyses suggested the G196A (Val66Met) polymorphism was significantly associated with cog</span>nitive impairment in PD, especially in Caucasian populations.
|
31365694 |
2019 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis implicates Val66Met BDNF polymorphism may be associated with Parkinson's disease cognitive impairment, further well-designed studies with larger populations are required to validate these results owing to the limited research.
|
31104169 |
2019 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
A total of 1,081 adults without dementia (375 healthy subjects and 706 individuals with mild cognitive impairment) were recruited from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to test the influence of BDNF Val66Met polymorphism on cognitive impairment, brain structure atrophy, and change in the levels of CSF biomarkers.
|
30775992 |
2019 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association between higher BDNF levels and cognitive impairment, mainly attention in smokers appears to be dependent on the BDNF Val66Met polymorphism.
|
30659208 |
2019 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several heritability studies have reported that the Brain Derived Neurotrophic Factor (<i>BDNF</i>) Val66Met genetic polymorphism could contribute to the acceleration of cognitive decline in aging.
|
30333719 |
2018 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
<i>BDNF</i> gene Val66Met variation may be associated with cognitive deficits in T2DM, especially with delayed memory.
|
29423073 |
2018 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the <i>BDNF</i> Val66Met polymorphism may play an important role in cognitive decline and could be considered as a target for novel AD therapeutics.
|
28468845 |
2017 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results support the hypothesis of the BDNF Val66Met polymorphism as a risk factor associated with cognitive impairment, corroborating previous findings in young and older adults.
|
28099630 |
2017 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest a role for BDNF Val66Met polymorphism on cognitive impairment in PD.
|
26806863 |
2016 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
This article reviews the current literature available regarding associations between the Val66Met polymorphism, childhood trauma and cognitive dysfunction in schizophrenia.
|
26603624 |
2016 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism, resting-state hippocampal functional connectivity and cognitive deficits in acute late-onset depression.
|
26000753 |
2015 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study investigated the effects of BDNF Val66Met polymorphism on functional magnetic resonance imaging (fMRI) during n-back WM tasks in healthy middle-aged adults.A total of 110 participants without subjective or objective cognitive impairment underwent BDNF genotyping.
|
26496261 |
2015 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings supported the hypothesis that the BDNF Val66Met polymorphism may affect susceptibility to regional WMH volume and such genotype-by-WMH interaction effect is correlated with cognitive decline in non-demented elderly males, in which the Met allele plays a protective role.
|
24275008 |
2014 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated whether a common Val66Met missense polymorphism (rs6265) of the BDNF gene is associated with individual differences in cognitive decline (marked by perceptual speed) in old age.
|
24660789 |
2014 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF G196A (Val66Met) polymorphism associated with cognitive impairment in Parkinson's disease.
|
24394906 |
2014 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF val66met polymorphism is a potential vulnerability factor for cognitive impairment in BD.
|
24862657 |
2014 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has previously been implicated in Alzheimer's disease (AD)-related cognitive impairment.
|
23769397 |
2013 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association between decreased BDNF serum levels and cognitive impairment in schizophrenia is dependent on the BDNF Val66Met polymorphism.
|
22362486 |
2012 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
The effect of the Val66Met polymorphism on synaptic transmission and plasticity in the IL-mPFC represents a mechanism to account for this impact of SNP on affective disorders and cognitive dysfunction.
|
22396415 |
2012 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met polymorphism is associated with cognitive impairment in Italian patients with Parkinson's disease.
|
19538209 |
2009 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings suggest that the functional BDNF Val66Met variant is not a major determinant of rate of cognitive decline in AD.
|
16627933 |
2006 |
|
rs759834365
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Met66 allele of the functional Val66Met polymorphism in the brain-derived neurotrophic factor gene confers protection against neurocognitive dysfunction in systemic lupus erythematosus.
|
16606648 |
2006 |