Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 472
Gene Symbol: ATM
ATM
Q13315 ATM serine/threonine kinase Kinase 684 0.374 0.885 5.6E-47 1.000 None 0.982 623 680 1953 2020
Entrez Id: 160140
Gene Symbol: C11orf65
C11orf65
Q8NCR3 chromosome 11 open reading frame 65 45 0.670 0.462 2.0E-14 0.100 None 1.000 180 265 1953 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
P04637 tumor protein p53 Transcription factor 2494 0.236 0.962 0.53 0.100 None 0.939 49 1 1992 2019
Entrez Id: 174
Gene Symbol: AFP
AFP
P02771 alpha fetoprotein Transporter 392 0.429 0.885 1.1E-11 0.100 None 0.944 18 0 1980 2019
Entrez Id: 1111
Gene Symbol: CHEK1
CHEK1
O14757 checkpoint kinase 1 Kinase 195 0.492 0.808 3.1E-08 0.100 None 1.000 15 0 1999 2020
Entrez Id: 3014
Gene Symbol: H2AX
H2AX
P16104 H2A.X variant histone Nucleic acid binding 212 0.484 0.808 0.18 0.100 None 1.000 15 0 2004 2019
Entrez Id: 4683
Gene Symbol: NBN
NBN
O60934 nibrin Nucleic acid binding 291 0.467 0.808 2.2E-16 0.100 None 1.000 14 0 1997 2011
Entrez Id: 545
Gene Symbol: ATR
ATR
Q13535 ATR serine/threonine kinase Kinase 321 0.456 0.923 3.5E-09 0.100 None 1.000 12 0 1995 2018
Entrez Id: 54840
Gene Symbol: APTX
APTX
Q7Z2E3 aprataxin Nucleic acid binding 94 0.590 0.500 4.0E-10 0.100 None 1.000 11 0 2000 2017
Entrez Id: 55655
Gene Symbol: NLRP2
NLRP2
Q9NX02 NLR family pyrin domain containing 2 155 0.515 0.731 1.4E-38 0.100 None 1.000 10 0 2002 2011
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
P49959 MRE11 homolog, double strand break repair nuclease 171 0.527 0.808 1.3E-12 0.090 None 1.000 9 0 2003 2019
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
P38936 cyclin dependent kinase inhibitor 1A 490 0.403 0.769 1.9E-03 0.080 None 0.875 8 0 1995 2013
Entrez Id: 23064
Gene Symbol: SETX
SETX
Q7Z333 senataxin Enzyme 133 0.570 0.731 0.95 0.080 None 0.875 8 1 2004 2018
Entrez Id: 23650
Gene Symbol: TRIM29
TRIM29
Q14134 tripartite motif containing 29 70 0.606 0.654 8.1E-08 0.080 None 1.000 8 0 1994 2019
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
O96017 checkpoint kinase 2 Kinase 297 0.460 0.808 1.2E-24 0.070 None 1.000 7 0 2006 2019
Entrez Id: 2395
Gene Symbol: FXN
FXN
Q16595 frataxin Enzyme 220 0.510 0.654 0.34 0.070 None 0.857 7 0 1989 2011
Entrez Id: 9623
Gene Symbol: TCL1B
TCL1B
O95988 T cell leukemia/lymphoma 1B 100 0.561 0.500 1.0E-02 0.070 None 0.857 7 0 1995 2004
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
P38398 BRCA1 DNA repair associated Enzyme 747 0.367 0.923 9.2E-29 0.060 None 1.000 6 0 1999 2015
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
T cell receptor beta variable 20/OR9-2 (non-functional) 456 0.403 0.923 0.060 None 1.000 6 0 1990 2014
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
P56279 T cell leukemia/lymphoma 1A 106 0.558 0.500 5.7E-10 0.060 None 0.833 6 0 1995 2004
Entrez Id: 952
Gene Symbol: CD38
CD38
P28907 CD38 molecule Enzyme 473 0.407 0.885 2.3E-06 0.050 None 1.000 5 0 1989 1994
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
P41212 ETS variant transcription factor 6 Transcription factor 241 0.477 0.731 0.97 0.050 None 1.000 5 0 1995 2019
Entrez Id: 7070
Gene Symbol: THY1
THY1
P04216 Thy-1 cell surface antigen 197 0.496 0.808 5.0E-02 0.050 None 0.800 5 0 1990 2000
Entrez Id: 5591
Gene Symbol: PRKDC
PRKDC
P78527 protein kinase, DNA-activated, catalytic subunit Kinase 131 0.540 0.808 1.00 0.040 None 1.000 4 0 2004 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
P51587 BRCA2 DNA repair associated Nucleic acid binding 656 0.379 0.846 2.4E-25 0.040 None 1.000 4 0 1997 2011