Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
P00533 epidermal growth factor receptor 892 0.325 0.862 0.50 0.700 0.974 2223 35 1989 2018
Entrez Id: 238
Gene Symbol: ALK
ALK
Q9UM73 ALK receptor tyrosine kinase 274 0.448 0.724 3.5E-06 0.700 0.979 482 9 2007 2018
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
P01116 KRAS proto-oncogene, GTPase enzyme modulator 886 0.350 0.724 9.0E-04 0.700 0.950 327 12 1989 2018
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
P04626 erb-b2 receptor tyrosine kinase 2 650 0.352 0.862 1.8E-03 0.700 0.978 99 9 1989 2018
Entrez Id: 673
Gene Symbol: BRAF
BRAF
P15056 B-Raf proto-oncogene, serine/threonine kinase 871 0.352 0.793 1.00 0.700 0.977 72 16 2002 2018
Entrez Id: 4233
Gene Symbol: MET
MET
P08581 MET proto-oncogene, receptor tyrosine kinase 407 0.405 0.793 0.99 0.600 0.972 111 4 2002 2018
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
P42771 Q8N726 cyclin dependent kinase inhibitor 2A 891 0.321 0.828 0.38 0.600 0.953 107 3 1994 2016
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
Q16236 nuclear factor, erythroid 2 like 2 cytoskeletal protein; hydrolase; nucleic acid binding; transcription factor 376 0.420 0.862 3.5E-03 0.600 0.964 28 0 2007 2018
Entrez Id: 55743
Gene Symbol: CHFR
CHFR
Q96EP1 checkpoint with forkhead and ring finger domains ligase 42 0.639 0.448 2.6E-03 0.550 0.800 5 0 2008 2016
Entrez Id: 25878
Gene Symbol: MXRA5
MXRA5
Q9NR99 matrix remodeling associated 5 5 0.857 0.069 3.0E-02 0.520 1.000 2 2 2012 2016
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 835 0.341 0.897 1.00 0.500 1.000 87 7 2004 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
P31749 AKT serine/threonine kinase 1 calcium-binding protein; kinase; transfer/carrier protein; transferase 760 0.355 0.862 0.98 0.500 1.000 68 3 2001 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
P60484 phosphatase and tensin homolog hydrolase; phosphatase 915 0.334 0.828 0.82 0.500 0.982 60 1 1998 2018
Entrez Id: 6794
Gene Symbol: STK11
STK11
Q15831 serine/threonine kinase 11 231 0.467 0.655 0.99 0.500 0.900 31 1 2006 2018
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1
Q02750 mitogen-activated protein kinase kinase 1 330 0.459 0.759 0.91 0.500 1.000 15 3 1995 2016
Entrez Id: 3815
Gene Symbol: KIT
KIT
P10721 KIT proto-oncogene receptor tyrosine kinase 462 0.394 0.759 0.99 0.460 1.000 8 1 1997 2015
Entrez Id: 208
Gene Symbol: AKT2
AKT2
P31751 AKT serine/threonine kinase 2 calcium-binding protein; kinase; transfer/carrier protein; transferase 163 0.512 0.655 0.61 0.440 1.000 6 1 2008 2016
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
P01111 NRAS proto-oncogene, GTPase enzyme modulator 477 0.420 0.690 0.53 0.430 1.000 13 5 1984 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
P04637 tumor protein p53 transcription factor 1773 0.251 0.897 0.17 0.400 0.966 359 9 1990 2018
Entrez Id: 2067
Gene Symbol: ERCC1
ERCC1
P07992 ERCC excision repair 1, endonuclease non-catalytic subunit nucleic acid binding 276 0.463 0.724 2.1E-07 0.400 0.977 129 4 2003 2018
Entrez Id: 27436
Gene Symbol: EML4
EML4
Q9HC35 echinoderm microtubule associated protein like 4 55 0.614 0.448 2.5E-03 0.400 0.975 121 0 2007 2018
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
P15692 vascular endothelial growth factor A signaling molecule 1174 0.298 0.897 2.7E-05 0.400 0.991 109 2 1999 2018
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
P08922 ROS proto-oncogene 1, receptor tyrosine kinase 165 0.493 0.759 1.5E-69 0.400 0.959 74 0 2008 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
P40763 signal transducer and activator of transcription 3 nucleic acid binding; transcription factor 706 0.358 0.862 1.00 0.400 1.000 48 0 2003 2018
Entrez Id: 6240
Gene Symbol: RRM1
RRM1
P23921 ribonucleotide reductase catalytic subunit M1 oxidoreductase 71 0.584 0.483 1.00 0.400 1.000 44 1 2004 2017