Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 348
Gene Symbol: APOE
APOE
P02649 apolipoprotein E 770 0.352 0.931 1.7E-03 0.400 0.892 395 2 1993 2018
Entrez Id: 351
Gene Symbol: APP
APP
P05067 amyloid beta precursor protein enzyme modulator 371 0.430 0.862 6.2E-02 0.400 0.982 89 8 1991 2018
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
P10636 microtubule associated protein tau 265 0.492 0.724 7.3E-03 0.400 0.983 67 10 1998 2018
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
P49768 presenilin 1 calcium-binding protein; hydrolase; protease; signaling molecule 268 0.490 0.690 0.98 0.400 0.974 51 15 1990 2018
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
F7VJQ1 P04156 prion protein 310 0.474 0.897 7.2E-04 0.400 0.903 32 2 1990 2015
Entrez Id: 1636
Gene Symbol: ACE
ACE
P12821 angiotensin I converting enzyme hydrolase; protease 624 0.367 0.897 1.6E-37 0.400 0.900 14 2 1998 2015
Entrez Id: 5664
Gene Symbol: PSEN2
PSEN2
P49810 presenilin 2 hydrolase; protease; signaling molecule 108 0.567 0.517 2.4E-03 0.400 0.900 13 3 1997 2011
Entrez Id: 7124
Gene Symbol: TNF
TNF
P01375 tumor necrosis factor signaling molecule 1640 0.263 0.966 0.80 0.390 0.889 10 1 1993 2012
Entrez Id: 627
Gene Symbol: BDNF
BDNF
P23560 brain derived neurotrophic factor signaling molecule 591 0.382 0.828 0.70 0.390 0.889 10 2 2007 2016
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
Q9NZC2 triggering receptor expressed on myeloid cells 2 178 0.572 0.552 4.0E-09 0.380 1.000 10 4 2003 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
P01584 interleukin 1 beta 1035 0.312 0.931 0.13 0.380 0.750 9 2 1993 2012
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
P03372 estrogen receptor 1 nucleic acid binding; receptor; transcription factor 686 0.355 0.897 1.00 0.370 0.857 8 3 2000 2014
Entrez Id: 590
Gene Symbol: BCHE
BCHE
P06276 butyrylcholinesterase 219 0.503 0.793 1.1E-12 0.360 1.000 7 0 1995 2013
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
P42898 methylenetetrahydrofolate reductase 699 0.354 0.828 1.2E-09 0.360 0.833 7 0 1999 2016
Entrez Id: 1191
Gene Symbol: CLU
CLU
P10909 clusterin 266 0.456 0.793 5.7E-05 0.340 0.750 7 1 1999 2018
Entrez Id: 43
Gene Symbol: ACHE
ACHE
P22303 acetylcholinesterase (Cartwright blood group) hydrolase; protease 219 0.494 0.793 1.00 0.340 1.000 6 0 2006 2016
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
P56817 beta-secretase 1 hydrolase; protease 56 0.616 0.517 0.88 0.330 0.667 4 0 2006 2016
Entrez Id: 3416
Gene Symbol: IDE
IDE
P14735 insulin degrading enzyme hydrolase; protease 47 0.627 0.483 9.1E-03 0.330 0.667 4 0 2007 2016
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
P05019 insulin like growth factor 1 715 0.355 0.828 0.29 0.330 1.000 4 0 2005 2015
Entrez Id: 8301
Gene Symbol: PICALM
PICALM
Q13492 phosphatidylinositol binding clathrin assembly protein membrane traffic protein 36 0.639 0.310 1.00 0.320 1.000 4 0 2009 2016
Entrez Id: 1471
Gene Symbol: CST3
CST3
P01034 cystatin C 167 0.500 0.724 3.9E-03 0.320 1.000 4 0 1996 2010
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
P37231 peroxisome proliferator activated receptor gamma nucleic acid binding; receptor; transcription factor 540 0.388 0.828 0.14 0.320 0.500 4 2 2005 2013
Entrez Id: 1565
Gene Symbol: CYP2D6
CYP2D6
P10635 cytochrome P450 family 2 subfamily D member 6 312 0.461 0.724 2.2E-23 0.320 1.000 3 0 1995 2008
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
P08069 insulin like growth factor 1 receptor 373 0.433 0.828 0.99 0.320 1.000 3 0 2005 2015
Entrez Id: 55676
Gene Symbol: SLC30A6
SLC30A6
Q6NXT4 solute carrier family 30 member 6 14 0.735 0.207 3.4E-08 0.320 1.000 3 0 2006 2014