Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
Q13635 patched 1 386 0.435 0.759 1.00 0.900 1.000 48 0 1997 2016
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
P35222 catenin beta 1 412 0.417 0.759 1.00 0.800 0.813 23 8 1998 2016
Entrez Id: 51684
Gene Symbol: SUFU
SUFU
Q9UMX1 SUFU negative regulator of hedgehog signaling 132 0.565 0.621 1.00 0.700 0.889 12 5 2002 2017
Entrez Id: 6608
Gene Symbol: SMO
SMO
Q99835 smoothened, frizzled class receptor enzyme modulator; receptor; signaling molecule 141 0.520 0.690 8.0E-07 0.640 1.000 6 1 2001 2015
Entrez Id: 324
Gene Symbol: APC
APC
P25054 APC, WNT signaling pathway regulator 462 0.397 0.828 1.00 0.600 0.929 16 2 1995 2014
Entrez Id: 4613
Gene Symbol: MYCN
MYCN
P04198 MYCN proto-oncogene, bHLH transcription factor nucleic acid binding; transcription factor 232 0.481 0.759 0.89 0.500 1.000 26 1 1989 2016
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
P51587 BRCA2, DNA repair associated nucleic acid binding 358 0.426 0.793 5.5E-24 0.420 1.000 4 9 2003 2015
Entrez Id: 4683
Gene Symbol: NBN
NBN
O60934 nibrin nucleic acid binding 214 0.502 0.759 2.6E-16 0.420 1.000 2 2 2008 2012
Entrez Id: 5395
Gene Symbol: PMS2
PMS2
P54278 PMS1 homolog 2, mismatch repair system component nucleic acid binding 154 0.526 0.586 1.2E-27 0.420 1.000 2 1 2009 2013
Entrez Id: 8643
Gene Symbol: PTCH2
PTCH2
Q9Y6C5 patched 2 107 0.590 0.517 2.7E-16 0.410 1.000 1 1 1999 1999
Entrez Id: 4609
Gene Symbol: MYC
MYC
P01106 MYC proto-oncogene, bHLH transcription factor nucleic acid binding; transcription factor 499 0.382 0.724 1.00 0.400 0.939 52 0 1990 2017
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
P32243 orthodenticle homeobox 2 transcription factor 141 0.540 0.690 0.94 0.400 1.000 20 0 2000 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
Q86YC2 partner and localizer of BRCA2 122 0.569 0.552 7.3E-20 0.400 0 0
Entrez Id: 3090
Gene Symbol: HIC1
HIC1
Q14526 HIC ZBTB transcriptional repressor 1 transcription factor 126 0.542 0.517 0.13 0.390 1.000 9 0 2002 2008
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
P48736 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma kinase; transferase 490 0.385 0.862 1.5E-06 0.390 1.000 9 0 2006 2016
Entrez Id: 474
Gene Symbol: ATOH1
ATOH1
Q92858 atonal bHLH transcription factor 1 nucleic acid binding; transcription factor 37 0.659 0.276 1.9E-02 0.380 0.875 8 0 2005 2014
Entrez Id: 1021
Gene Symbol: CDK6
CDK6
Q00534 cyclin dependent kinase 6 kinase; transferase 178 0.508 0.690 0.98 0.370 1.000 9 0 2006 2013
Entrez Id: 11186
Gene Symbol: RASSF1
RASSF1
Q9NS23 Ras association domain family member 1 enzyme modulator 307 0.429 0.793 3.7E-06 0.370 0.857 7 0 2002 2012
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
P04626 erb-b2 receptor tyrosine kinase 2 650 0.352 0.862 1.8E-03 0.360 1.000 7 0 2001 2010
Entrez Id: 5156
Gene Symbol: PDGFRA
PDGFRA
P16234 platelet derived growth factor receptor alpha 278 0.456 0.690 1.00 0.360 1.000 7 0 2001 2015
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
P40763 signal transducer and activator of transcription 3 nucleic acid binding; transcription factor 706 0.358 0.862 1.00 0.360 1.000 7 0 2008 2015
Entrez Id: 8312
Gene Symbol: AXIN1
AXIN1
O15169 axin 1 69 0.600 0.483 0.73 0.350 0.750 5 1 2001 2007
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
Q92731 estrogen receptor 2 nucleic acid binding; receptor; transcription factor 297 0.445 0.828 5.4E-08 0.340 1.000 5 0 2009 2015
Entrez Id: 23476
Gene Symbol: BRD4
BRD4
O60885 bromodomain containing 4 119 0.529 0.759 1.00 0.320 1.000 3 0 2014 2016
Entrez Id: 6275
Gene Symbol: S100A4
S100A4
P26447 S100 calcium binding protein A4 calcium-binding protein; signaling molecule 194 0.483 0.621 6.7E-03 0.320 1.000 2 0 2003 2007