Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 4763
Gene Symbol: NF1
NF1
P21359 neurofibromin 1 enzyme modulator 308 0.458 0.724 1.00 1.000 definitive 0.951 445 358 1988 2018
Entrez Id: 161742
Gene Symbol: SPRED1
SPRED1
Q7Z699 sprouty related EVH1 domain containing 1 receptor 50 0.672 0.517 0.96 0.600 strong 0.846 13 0 2007 2017
Entrez Id: 673
Gene Symbol: BRAF
BRAF
P15056 B-Raf proto-oncogene, serine/threonine kinase 871 0.352 0.793 1.00 0.380 strong 1.000 9 1 2009 2015
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
Q06124 protein tyrosine phosphatase, non-receptor type 11 441 0.429 0.828 1.00 0.350 strong 1.000 6 0 1996 2010
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
P40692 mutL homolog 1 nucleic acid binding 356 0.424 0.759 5.1E-05 0.350 strong 1.000 5 4 1999 2008
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
P43246 mutS homolog 2 nucleic acid binding 320 0.437 0.690 0.91 0.340 strong 1.000 4 2 2002 2010
Entrez Id: 5395
Gene Symbol: PMS2
PMS2
P54278 PMS1 homolog 2, mismatch repair system component nucleic acid binding 154 0.526 0.586 1.2E-27 0.330 strong 0.667 4 1 2008 2016
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
P51587 BRCA2, DNA repair associated nucleic acid binding 358 0.426 0.793 5.5E-24 0.320 strong 1.000 4 0 2002 2016
Entrez Id: 4254
Gene Symbol: KITLG
KITLG
P21583 KIT ligand 181 0.491 0.759 0.86 0.320 strong 2 0 2004 2006
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
P52701 mutS homolog 6 189 0.495 0.586 2.2E-05 0.320 strong 1.000 2 0 2005 2016
Entrez Id: 5894
Gene Symbol: RAF1
RAF1
P04049 Raf-1 proto-oncogene, serine/threonine kinase 328 0.462 0.793 0.89 0.310 strong 1.000 2 0 2007 2011
Entrez Id: 57697
Gene Symbol: FANCM
FANCM
Q8IYD8 FA complementation group M nucleic acid binding 52 0.672 0.414 6.3E-15 0.300 limited 3 0 2005 2015
Entrez Id: 5422
Gene Symbol: POLA1
POLA1
P09884 DNA polymerase alpha 1, catalytic subunit 61 0.676 0.621 1.00 0.300 moderate 3 0 2005 2016
Entrez Id: 55120
Gene Symbol: FANCL
FANCL
Q9NW38 FA complementation group L ligase 58 0.642 0.586 8.1E-23 0.300 strong 2 0 2009 2016
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
Q9BX63 BRCA1 interacting protein C-terminal helicase 1 nucleic acid binding 89 0.586 0.552 4.8E-17 0.300 strong 2 0 2005 2005
Entrez Id: 2175
Gene Symbol: FANCA
FANCA
O15360 FA complementation group A 123 0.567 0.621 4.3E-68 0.300 strong 2 0 1996 1998
Entrez Id: 84464
Gene Symbol: SLX4
SLX4
Q8IY92 SLX4 structure-specific endonuclease subunit 49 0.672 0.517 2.3E-20 0.300 strong 2 0 2011 2011
Entrez Id: 55215
Gene Symbol: FANCI
FANCI
Q9NVI1 FA complementation group I 41 0.701 0.414 2.8E-35 0.300 strong 1 0 2007 2007
Entrez Id: 2177
Gene Symbol: FANCD2
FANCD2
Q9BXW9 FA complementation group D2 154 0.534 0.724 2.1E-30 0.300 strong 1 0 2001 2001
Entrez Id: 2187
Gene Symbol: FANCB
FANCB
Q8NB91 FA complementation group B 160 0.520 0.586 1.00 0.300 strong 1 0 2004 2004
Entrez Id: 2778
Gene Symbol: GNAS
GNAS
O95467 P63092 P84996 Q5JWF2 GNAS complex locus enzyme modulator 394 0.443 0.793 0.71 0.300 strong 1 0 1991 1991
Entrez Id: 2189
Gene Symbol: FANCG
FANCG
O15287 FA complementation group G 60 0.648 0.483 2.1E-13 0.300 strong 1 0 1998 1998
Entrez Id: 29089
Gene Symbol: UBE2T
UBE2T
Q9NPD8 ubiquitin conjugating enzyme E2 T 48 0.681 0.448 1.2E-05 0.300 limited 1 0 2015 2015
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1
Q02750 mitogen-activated protein kinase kinase 1 330 0.459 0.759 0.91 0.300 limited 1 0 2015 2015
Entrez Id: 2072
Gene Symbol: ERCC4
ERCC4
Q92889 ERCC excision repair 4, endonuclease catalytic subunit nucleic acid binding 228 0.503 0.724 3.8E-12 0.300 limited 0 0