Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
P04626 erb-b2 receptor tyrosine kinase 2 650 0.352 0.862 1.8E-03 0.700 0.875 20 1 1989 2015
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 835 0.341 0.897 1.00 0.640 1.000 13 3 2003 2016
Entrez Id: 324
Gene Symbol: APC
APC
P25054 APC, WNT signaling pathway regulator 462 0.397 0.828 1.00 0.630 0.667 4 2 1992 2008
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
P21802 fibroblast growth factor receptor 2 665 0.398 0.759 1.00 0.620 6 1 1999 2012
Entrez Id: 4595
Gene Symbol: MUTYH
MUTYH
Q9UIF7 mutY DNA glycosylase hydrolase; nucleic acid binding 99 0.551 0.621 2.7E-17 0.610 24 5 2002 2015
Entrez Id: 3659
Gene Symbol: IRF1
IRF1
P10914 interferon regulatory factor 1 nucleic acid binding; transcription factor 165 0.503 0.724 0.99 0.610 1.000 2 1 1998 2013
Entrez Id: 1316
Gene Symbol: KLF6
KLF6
Q99612 Kruppel like factor 6 nucleic acid binding; transcription factor 125 0.534 0.690 0.98 0.610 1 1 2005 2005
Entrez Id: 999
Gene Symbol: CDH1
CDH1
P12830 cadherin 1 322 0.432 0.759 0.11 0.600 1.000 32 0 1998 2017
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
P42771 Q8N726 cyclin dependent kinase inhibitor 2A 891 0.321 0.828 0.38 0.600 0.875 12 0 1997 2013
Entrez Id: 843
Gene Symbol: CASP10
CASP10
Q92851 caspase 10 enzyme modulator; hydrolase; protease 102 0.561 0.517 5.2E-12 0.600 2 2 2002 2002
Entrez Id: 332
Gene Symbol: BIRC5
BIRC5
O15392 baculoviral IAP repeat containing 5 enzyme modulator 191 0.479 0.655 5.7E-02 0.570 9 0 2002 2008
Entrez Id: 4233
Gene Symbol: MET
MET
P08581 MET proto-oncogene, receptor tyrosine kinase 407 0.405 0.793 0.99 0.560 1.000 8 0 1991 2016
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
P38936 cyclin dependent kinase inhibitor 1A 369 0.415 0.724 2.1E-03 0.530 1.000 4 0 2004 2017
Entrez Id: 472
Gene Symbol: ATM
ATM
Q13315 ATM serine/threonine kinase kinase; nucleic acid binding; transferase 486 0.401 0.862 6.0E-46 0.520 1.000 3 0 2001 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
P04637 tumor protein p53 transcription factor 1773 0.251 0.897 0.17 0.500 0.923 34 0 1991 2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
P01116 KRAS proto-oncogene, GTPase enzyme modulator 886 0.350 0.724 9.0E-04 0.460 1.000 16 2 1993 2016
Entrez Id: 2065
Gene Symbol: ERBB3
ERBB3
P21860 erb-b2 receptor tyrosine kinase 3 222 0.473 0.690 6.7E-15 0.420 3 1 2008 2013
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
Q96QB1 DLC1 Rho GTPase activating protein 81 0.573 0.655 1.00 0.410 2 0 2003 2016
Entrez Id: 8313
Gene Symbol: AXIN2
AXIN2
Q9Y2T1 axin 2 91 0.570 0.552 0.66 0.410 1.000 1 0 2017 2017
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
P35354 prostaglandin-endoperoxide synthase 2 oxidoreductase 832 0.338 0.897 1.00 0.400 1.000 34 0 1999 2016
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
P01584 interleukin 1 beta 1035 0.312 0.931 0.13 0.400 1.000 20 0 2002 2014
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
Q13761 runt related transcription factor 3 nucleic acid binding; transcription factor 168 0.494 0.690 0.96 0.400 1.000 19 0 2003 2014
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
P42898 methylenetetrahydrofolate reductase 699 0.354 0.828 1.2E-09 0.400 1.000 15 0 2002 2012
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
P40763 signal transducer and activator of transcription 3 nucleic acid binding; transcription factor 706 0.358 0.862 1.00 0.400 1.000 11 0 2003 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
P00533 epidermal growth factor receptor 892 0.325 0.862 0.50 0.380 1.000 11 0 1995 2016