Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
Q06124 protein tyrosine phosphatase, non-receptor type 11 441 0.429 0.828 1.00 0.900 0.968 113 44 1993 2018
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
P01111 NRAS proto-oncogene, GTPase enzyme modulator 477 0.420 0.690 0.53 0.440 1.000 5 4 1993 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
P15056 B-Raf proto-oncogene, serine/threonine kinase 871 0.352 0.793 1.00 0.420 1.000 5 5 1993 2015
Entrez Id: 6654
Gene Symbol: SOS1
SOS1
Q07889 SOS Ras/Rac guanine nucleotide exchange factor 1 enzyme modulator 183 0.536 0.655 1.00 0.400 0.905 22 1 2007 2018
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
P01116 KRAS proto-oncogene, GTPase enzyme modulator 886 0.350 0.724 9.0E-04 0.400 1.000 14 5 2006 2014
Entrez Id: 5894
Gene Symbol: RAF1
RAF1
P04049 Raf-1 proto-oncogene, serine/threonine kinase 328 0.462 0.793 0.89 0.400 1.000 11 0 2007 2014
Entrez Id: 8036
Gene Symbol: SHOC2
SHOC2
Q9UQ13 SHOC2, leucine rich repeat scaffold protein 62 0.681 0.448 1.00 0.340 1.000 5 1 2009 2014
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1
Q02750 mitogen-activated protein kinase kinase 1 330 0.459 0.759 0.91 0.320 1.000 3 0 2007 2014
Entrez Id: 5605
Gene Symbol: MAP2K2
MAP2K2
P36507 mitogen-activated protein kinase kinase 2 177 0.559 0.586 0.97 0.320 1.000 3 0 2007 2007
Entrez Id: 1969
Gene Symbol: EPHA2
EPHA2
P29317 EPH receptor A2 127 0.526 0.690 9.0E-06 0.310 1.000 2 0 2013 2014
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
P01112 HRas proto-oncogene, GTPase enzyme modulator 545 0.404 0.828 8.7E-02 0.310 1.000 2 0 2007 2007
Entrez Id: 52
Gene Symbol: ACP1
ACP1
P24666 acid phosphatase 1 84 0.582 0.655 1.8E-08 0.100 1.000 13 1 2002 2018
Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
P29323 EPH receptor B2 331 0.425 0.759 1.00 0.090 1.000 9 1 2007 2014
Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1
P28482 mitogen-activated protein kinase 1 kinase; transferase 525 0.387 0.862 1.00 0.090 1.000 9 0 2007 2014
Entrez Id: 6016
Gene Symbol: RIT1
RIT1
Q92963 Ras like without CAAX 1 enzyme modulator 113 0.619 0.621 0.15 0.050 1.000 5 0 2013 2017
Entrez Id: 867
Gene Symbol: CBL
CBL
P22681 Cbl proto-oncogene ligase 143 0.550 0.586 4.5E-03 0.040 1.000 4 0 2010 2016
Entrez Id: 5609
Gene Symbol: MAP2K7
MAP2K7
O14733 mitogen-activated protein kinase kinase 7 231 0.462 0.759 1.00 0.030 1.000 3 0 2008 2012
Entrez Id: 22882
Gene Symbol: ZHX2
ZHX2
Q9Y6X8 zinc fingers and homeoboxes 2 nucleic acid binding; transcription factor 115 0.534 0.586 4.1E-02 0.030 1.000 3 0 2008 2014
Entrez Id: 79594
Gene Symbol: MUL1
MUL1
Q969V5 mitochondrial E3 ubiquitin protein ligase 1 142 0.514 0.655 1.8E-06 0.020 1.000 2 0 2010 2016
Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3
P27361 mitogen-activated protein kinase 3 kinase; transferase 345 0.429 0.828 1.0E-01 0.020 1.000 2 0 2007 2009
Entrez Id: 9019
Gene Symbol: MPZL1
MPZL1
O95297 myelin protein zero like 1 cell adhesion molecule; transporter 14 0.785 0.276 0.15 0.020 1.000 2 0 2008 2014
Entrez Id: 158506
Gene Symbol: CBLL2
CBLL2
Q8N7E2 Cbl proto-oncogene like 2 ligase 145 0.511 0.655 0.020 1.000 2 0 2010 2016
Entrez Id: 6655
Gene Symbol: SOS2
SOS2
Q07890 SOS Ras/Rho guanine nucleotide exchange factor 2 enzyme modulator 79 0.681 0.517 1.00 0.020 1.000 2 0 2016 2016
Entrez Id: 2688
Gene Symbol: GH1
GH1
P01241 growth hormone 1 signaling molecule 316 0.438 0.793 3.2E-02 0.020 1.000 2 0 2005 2005
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
O60260 parkin RBR E3 ubiquitin protein ligase ligase 245 0.464 0.793 0.020 1.000 2 0 2010 2016