Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 673
Gene Symbol: BRAF
BRAF
P15056 B-Raf proto-oncogene, serine/threonine kinase 871 0.352 0.793 1.00 0.800 1.000 24 14 2003 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
P00533 epidermal growth factor receptor 892 0.325 0.862 0.50 0.700 0.975 516 14 1990 2018
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
P01116 KRAS proto-oncogene, GTPase enzyme modulator 886 0.350 0.724 9.0E-04 0.700 0.940 122 3 1990 2018
Entrez Id: 238
Gene Symbol: ALK
ALK
Q9UM73 ALK receptor tyrosine kinase 274 0.448 0.724 3.5E-06 0.700 0.978 99 6 2008 2018
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
P04626 erb-b2 receptor tyrosine kinase 2 650 0.352 0.862 1.8E-03 0.700 1.000 29 7 1991 2017
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
P08922 ROS proto-oncogene 1, receptor tyrosine kinase 165 0.493 0.759 1.5E-69 0.700 1.000 20 1 2012 2018
Entrez Id: 6794
Gene Symbol: STK11
STK11
Q15831 serine/threonine kinase 11 231 0.467 0.655 0.99 0.700 1.000 18 2 2002 2017
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
P22607 fibroblast growth factor receptor 3 558 0.417 0.759 1.8E-05 0.640 1.000 5 1 2013 2017
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1
Q02750 mitogen-activated protein kinase kinase 1 330 0.459 0.759 0.91 0.630 1.000 5 6 2008 2016
Entrez Id: 207
Gene Symbol: AKT1
AKT1
P31749 AKT serine/threonine kinase 1 calcium-binding protein; kinase; transfer/carrier protein; transferase 760 0.355 0.862 0.98 0.500 1.000 13 1 2008 2017
Entrez Id: 4609
Gene Symbol: MYC
MYC
P01106 MYC proto-oncogene, bHLH transcription factor nucleic acid binding; transcription factor 499 0.382 0.724 1.00 0.500 1.000 13 3 2008 2016
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 835 0.341 0.897 1.00 0.500 1.000 13 19 2004 2017
Entrez Id: 8626
Gene Symbol: TP63
TP63
Q9H3D4 tumor protein p63 transcription factor 475 0.419 0.759 1.00 0.460 0.833 9 5 2010 2017
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
Q16236 nuclear factor, erythroid 2 like 2 cytoskeletal protein; hydrolase; nucleic acid binding; transcription factor 376 0.420 0.862 3.5E-03 0.450 1.000 7 5 2010 2017
Entrez Id: 81037
Gene Symbol: CLPTM1L
CLPTM1L
Q96KA5 CLPTM1 like lyase 60 0.602 0.517 5.7E-05 0.430 1.000 5 2 2009 2016
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
P21802 fibroblast growth factor receptor 2 665 0.398 0.759 1.00 0.420 1.000 4 5 2008 2017
Entrez Id: 5894
Gene Symbol: RAF1
RAF1
P04049 Raf-1 proto-oncogene, serine/threonine kinase 328 0.462 0.793 0.89 0.420 1.000 3 1 2014 2018
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
P35222 catenin beta 1 412 0.417 0.759 1.00 0.410 1.000 3 9 2001 2016
Entrez Id: 369
Gene Symbol: ARAF
ARAF
P10398 A-Raf proto-oncogene, serine/threonine kinase 21 0.701 0.414 0.95 0.410 1.000 2 2 2014 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
P04637 tumor protein p53 transcription factor 1773 0.251 0.897 0.17 0.400 1.000 49 80 1994 2016
Entrez Id: 27436
Gene Symbol: EML4
EML4
Q9HC35 echinoderm microtubule associated protein like 4 55 0.614 0.448 2.5E-03 0.400 1.000 19 0 2011 2017
Entrez Id: 7270
Gene Symbol: TTF1
TTF1
Q15361 transcription termination factor 1 54 0.616 0.379 8.6E-13 0.400 1.000 15 0 2010 2016
Entrez Id: 324
Gene Symbol: APC
APC
P25054 APC, WNT signaling pathway regulator 462 0.397 0.828 1.00 0.400 2 1 2008 2015
Entrez Id: 2044
Gene Symbol: EPHA5
EPHA5
P54756 EPH receptor A5 15 0.743 0.241 3.1E-05 0.400 2 2 2005 2007
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
P01112 HRas proto-oncogene, GTPase enzyme modulator 545 0.404 0.828 8.7E-02 0.400 2 9 2016 2016