Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
P01116 KRAS proto-oncogene, GTPase enzyme modulator 886 0.350 0.724 9.0E-04 0.700 0.948 125 3 1986 2018
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
Q13485 SMAD family member 4 transcription factor 426 0.430 0.759 1.00 0.700 0.985 68 4 1996 2018
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
P42771 Q8N726 cyclin dependent kinase inhibitor 2A 891 0.321 0.828 0.38 0.600 0.987 80 7 1995 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
P04637 tumor protein p53 transcription factor 1773 0.251 0.897 0.17 0.500 0.982 114 10 1992 2018
Entrez Id: 6794
Gene Symbol: STK11
STK11
Q15831 serine/threonine kinase 11 231 0.467 0.655 0.99 0.450 1.000 5 4 1999 2010
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
P51587 BRCA2, DNA repair associated nucleic acid binding 358 0.426 0.793 5.5E-24 0.400 0.925 53 2 1995 2017
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
P38398 BRCA1, DNA repair associated ligase 411 0.410 0.862 1.8E-28 0.400 1.000 20 0 2002 2018
Entrez Id: 208
Gene Symbol: AKT2
AKT2
P31751 AKT serine/threonine kinase 2 calcium-binding protein; kinase; transfer/carrier protein; transferase 163 0.512 0.655 0.61 0.380 1.000 8 0 1996 2018
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
P04179 superoxide dismutase 2 oxidoreductase 488 0.396 0.897 0.16 0.370 1.000 8 1 2001 2012
Entrez Id: 324
Gene Symbol: APC
APC
P25054 APC, WNT signaling pathway regulator 462 0.397 0.828 1.00 0.370 0.857 7 1 1992 2017
Entrez Id: 6416
Gene Symbol: MAP2K4
MAP2K4
P45985 mitogen-activated protein kinase kinase 4 69 0.582 0.586 1.00 0.350 1.000 5 1 2002 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
P15056 B-Raf proto-oncogene, serine/threonine kinase 871 0.352 0.793 1.00 0.340 1.000 4 1 2003 2016
Entrez Id: 84260
Gene Symbol: TCHP
TCHP
Q9BT92 trichoplein keratin filament binding 124 0.520 0.759 2.5E-16 0.310 1.000 2 1 2009 2015
Entrez Id: 54894
Gene Symbol: RNF43
RNF43
Q68DV7 ring finger protein 43 47 0.648 0.276 0.57 0.310 < 0.001 1 0 2013 2013
Entrez Id: 4609
Gene Symbol: MYC
MYC
P01106 MYC proto-oncogene, bHLH transcription factor nucleic acid binding; transcription factor 499 0.382 0.724 1.00 0.300 1.000 12 0 2002 2017
Entrez Id: 2033
Gene Symbol: EP300
EP300
Q09472 E1A binding protein p300 nucleic acid binding; transcription factor; transferase 322 0.489 0.828 1.00 0.300 0 0
Entrez Id: 5932
Gene Symbol: RBBP8
RBBP8
Q99708 RB binding protein 8, endonuclease transcription factor 117 0.611 0.586 2.2E-11 0.300 0 0
Entrez Id: 3181
Gene Symbol: HNRNPA2B1
HNRNPA2B1
P22626 heterogeneous nuclear ribonucleoprotein A2/B1 83 0.607 0.655 1.00 0.230 1.000 4 0 2011 2014
Entrez Id: 7015
Gene Symbol: TERT
TERT
O14746 telomerase reverse transcriptase nucleic acid binding 541 0.393 0.828 1.00 0.200 1.000 14 3 2005 2018
Entrez Id: 1107
Gene Symbol: CHD3
CHD3
Q12873 chromodomain helicase DNA binding protein 3 9 0.815 0.310 1.00 0.200 1 0 2011 2011
Entrez Id: 2494
Gene Symbol: NR5A2
NR5A2
O00482 nuclear receptor subfamily 5 group A member 2 transcription factor 62 0.609 0.483 0.20 0.180 0.875 10 2 2010 2018
Entrez Id: 81037
Gene Symbol: CLPTM1L
CLPTM1L
Q96KA5 CLPTM1 like lyase 60 0.602 0.517 5.7E-05 0.150 1.000 9 2 2010 2018
Entrez Id: 80781
Gene Symbol: COL18A1
COL18A1
P39060 collagen type XVIII alpha 1 chain 188 0.489 0.759 1.5E-09 0.150 1.000 6 1 2007 2016
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
P20823 HNF1 homeobox A nucleic acid binding; transcription factor 187 0.515 0.621 0.96 0.140 1.000 5 1 2011 2016
Entrez Id: 91
Gene Symbol: ACVR1B
ACVR1B
P36896 activin A receptor type 1B kinase; receptor; transferase 23 0.735 0.207 1.00 0.130 1.000 3 1 2001 2016