Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
P49768 presenilin 1 calcium-binding protein; hydrolase; protease; signaling molecule 268 0.490 0.690 0.98 0.600 0.962 247 28 1989 2018
Entrez Id: 351
Gene Symbol: APP
APP
P05067 amyloid beta precursor protein enzyme modulator 371 0.430 0.862 6.2E-02 0.600 0.972 210 16 1988 2018
Entrez Id: 5664
Gene Symbol: PSEN2
PSEN2
P49810 presenilin 2 hydrolase; protease; signaling molecule 108 0.567 0.517 2.4E-03 0.600 0.947 77 8 1995 2017
Entrez Id: 6653
Gene Symbol: SORL1
SORL1
Q92673 sortilin related receptor 1 receptor; transporter 69 0.619 0.483 1.1E-09 0.530 0.667 3 0 2006 2017
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
Q9NZC2 triggering receptor expressed on myeloid cells 2 178 0.572 0.552 4.0E-09 0.510 1.000 3 0 2015 2017
Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
Q8IZY2 ATP binding cassette subfamily A member 7 transporter 46 0.690 0.379 4.5E-55 0.500 2 0 2011 2015
Entrez Id: 348
Gene Symbol: APOE
APOE
P02649 apolipoprotein E 770 0.352 0.931 1.7E-03 0.400 0.931 34 2 1993 2016
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
P10636 microtubule associated protein tau 265 0.492 0.724 7.3E-03 0.330 1.000 10 1 2003 2016
Entrez Id: 836
Gene Symbol: CASP3
CASP3
P42574 caspase 3 enzyme modulator; hydrolase; protease 462 0.391 0.862 0.28 0.330 1.000 4 0 2001 2008
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
P01584 interleukin 1 beta 1035 0.312 0.931 0.13 0.320 1.000 3 0 2000 2013
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
F7VJQ1 P04156 prion protein 310 0.474 0.897 7.2E-04 0.320 0.500 3 0 2000 2012
Entrez Id: 3630
Gene Symbol: INS
INS
P01308 insulin 309 0.458 0.828 0.32 0.310 < 0.001 3 0 1998 2005
Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
P49841 glycogen synthase kinase 3 beta kinase; transferase 185 0.488 0.793 0.96 0.310 1.000 3 0 2007 2013
Entrez Id: 274
Gene Symbol: BIN1
BIN1
O00499 bridging integrator 1 109 0.573 0.621 0.77 0.310 < 0.001 2 0 2011 2014
Entrez Id: 3416
Gene Symbol: IDE
IDE
P14735 insulin degrading enzyme hydrolase; protease 47 0.627 0.483 9.1E-03 0.310 1.000 2 0 2007 2010
Entrez Id: 1718
Gene Symbol: DHCR24
DHCR24
Q15392 24-dehydrocholesterol reductase oxidoreductase 104 0.572 0.655 3.8E-02 0.310 1.000 2 0 2008 2013
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
O96008 translocase of outer mitochondrial membrane 40 membrane traffic protein 72 0.636 0.483 0.99 0.310 1.000 1 0 2014 2014
Entrez Id: 1636
Gene Symbol: ACE
ACE
P12821 angiotensin I converting enzyme hydrolase; protease 624 0.367 0.897 1.6E-37 0.300 4 0 1999 2007
Entrez Id: 1191
Gene Symbol: CLU
CLU
P10909 clusterin 266 0.456 0.793 5.7E-05 0.300 3 0 2009 2011
Entrez Id: 2
Gene Symbol: A2M
A2M
P01023 alpha-2-macroglobulin defense/immunity protein; enzyme modulator; signaling molecule 86 0.564 0.724 5.6E-11 0.300 3 0 1998 2004
Entrez Id: 1378
Gene Symbol: CR1
CR1
P17927 complement C3b/C4b receptor 1 (Knops blood group) 51 0.607 0.621 1.1E-33 0.300 2 0 2009 2011
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
Q9Y5K6 CD2 associated protein signaling molecule 52 0.642 0.448 0.29 0.300 2 0 2011 2011
Entrez Id: 4129
Gene Symbol: MAOB
MAOB
P27338 monoamine oxidase B nucleic acid binding; oxidoreductase; transferase 82 0.575 0.724 1.00 0.300 2 0 1995 2011
Entrez Id: 3077
Gene Symbol: HFE
HFE
Q30201 homeostatic iron regulator 334 0.440 0.690 3.0E-08 0.300 2 0 2004 2006
Entrez Id: 1471
Gene Symbol: CST3
CST3
P01034 cystatin C 167 0.500 0.724 3.9E-03 0.300 2 0 2007 2007