Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
P38398 BRCA1 DNA repair associated Enzyme 747 0.367 0.923 9.2E-29 0.400 None 0.946 297 12 1993 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
P51587 BRCA2 DNA repair associated Nucleic acid binding 656 0.379 0.846 2.4E-25 0.400 None 0.961 205 3 1995 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
P04637 tumor protein p53 Transcription factor 2494 0.236 0.962 0.53 0.100 None 0.969 32 6 1992 2019
Entrez Id: 5888
Gene Symbol: RAD51
RAD51
Q06609 RAD51 recombinase 363 0.447 0.846 2.7E-02 0.100 None 0.909 11 1 1999 2016
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
P04626 erb-b2 receptor tyrosine kinase 2 Kinase 995 0.328 0.923 6.0E-03 0.080 None 0.875 8 3 2000 2015
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
Q9BX63 BRCA1 interacting protein C-terminal helicase 1 Enzyme 194 0.507 0.731 6.2E-17 0.080 None 0.875 8 0 2007 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
P03372 estrogen receptor 1 Nuclear receptor 1101 0.324 0.962 1.00 0.070 None 0.857 7 1 1995 2013
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
P60484 phosphatase and tensin homolog Enzyme 1349 0.305 0.923 0.26 0.060 None 0.833 6 0 2002 2019
Entrez Id: 60500
Gene Symbol: BRCA3
BRCA3
breast cancer 3 27 0.705 0.269 0.060 None 1.000 6 0 2007 2017
Entrez Id: 142
Gene Symbol: PARP1
PARP1
P09874 poly(ADP-ribose) polymerase 1 565 0.389 0.923 3.3E-04 0.050 None 1.000 5 0 2012 2015
Entrez Id: 57697
Gene Symbol: FANCM
FANCM
Q8IYD8 FA complementation group M Enzyme 147 0.543 0.731 2.4E-15 0.050 None 1.000 5 1 2009 2019
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
P18887 X-ray repair cross complementing 1 410 0.421 0.923 6.3E-09 0.040 None 0.750 4 2 2006 2016
Entrez Id: 115761
Gene Symbol: ARL11
ARL11
Q969Q4 ADP ribosylation factor like GTPase 11 35 0.670 0.423 5.3E-03 0.040 None 1.000 4 4 2006 2011
Entrez Id: 1302
Gene Symbol: COL11A2
COL11A2
P13942 collagen type XI alpha 2 chain 399 0.435 0.846 0.70 0.040 None 1.000 4 0 2012 2015
Entrez Id: 5245
Gene Symbol: PHB
PHB
P35232 prohibitin 177 0.511 0.846 0.76 0.030 None 1.000 3 0 1992 2008
Entrez Id: 1647
Gene Symbol: GADD45A
GADD45A
P24522 growth arrest and DNA damage inducible alpha 151 0.526 0.769 4.4E-02 0.030 None 0.667 3 0 2004 2018
Entrez Id: 7251
Gene Symbol: TSG101
TSG101
Q99816 tumor susceptibility 101 Enzyme 80 0.588 0.615 0.34 0.030 None 1.000 3 0 1998 2002
Entrez Id: 55655
Gene Symbol: NLRP2
NLRP2
Q9NX02 NLR family pyrin domain containing 2 155 0.515 0.731 1.4E-38 0.030 None 0.667 3 0 2012 2014
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
P05019 insulin like growth factor 1 1206 0.318 0.885 0.27 0.030 None 1.000 3 0 2005 2008
Entrez Id: 3294
Gene Symbol: HSD17B2
HSD17B2
P37059 hydroxysteroid 17-beta dehydrogenase 2 Enzyme 42 0.656 0.385 1.8E-10 0.030 None 1.000 3 0 1994 2007
Entrez Id: 11186
Gene Symbol: RASSF1
RASSF1
Q9NS23 Ras association domain family member 1 Enzyme modulator 400 0.420 0.808 4.9E-06 0.030 None 0.667 3 0 2010 2014
Entrez Id: 6794
Gene Symbol: STK11
STK11
Q15831 serine/threonine kinase 11 Kinase 372 0.435 0.808 0.99 0.030 None 1.000 3 0 2000 2015
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
Q00987 MDM2 proto-oncogene Nucleic acid binding 702 0.362 0.846 1.00 0.030 None 0.667 3 0 2006 2011
Entrez Id: 56946
Gene Symbol: EMSY
EMSY
Q7Z589 EMSY transcriptional repressor, BRCA2 interacting 52 0.628 0.423 1.00 0.020 None 1.000 2 0 2011 2017
Entrez Id: 3292
Gene Symbol: HSD17B1
HSD17B1
P14061 hydroxysteroid 17-beta dehydrogenase 1 Enzyme 69 0.610 0.615 1.3E-04 0.020 None 1.000 2 0 1994 1994