Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
P51587 BRCA2, DNA repair associated nucleic acid binding 358 0.426 0.793 5.5E-24 0.800 strong 0.947 215 110 1993 2018
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
Q86YC2 partner and localizer of BRCA2 122 0.569 0.552 7.3E-20 0.800 definitive 0.964 113 166 2006 2018
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
P38398 BRCA1, DNA repair associated ligase 411 0.410 0.862 1.8E-28 0.700 0.937 297 144 1993 2018
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
O96017 checkpoint kinase 2 195 0.494 0.621 1.2E-23 0.700 definitive 0.947 78 75 2000 2018
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
Q9BX63 BRCA1 interacting protein C-terminal helicase 1 nucleic acid binding 89 0.586 0.552 4.8E-17 0.650 limited 1.000 41 67 2001 2017
Entrez Id: 580
Gene Symbol: BARD1
BARD1
Q99728 BRCA1 associated RING domain 1 54 0.624 0.379 2.2E-24 0.650 definitive 0.800 40 34 2001 2017
Entrez Id: 4683
Gene Symbol: NBN
NBN
O60934 nibrin nucleic acid binding 214 0.502 0.759 2.6E-16 0.630 limited 0.667 8 1 2000 2015
Entrez Id: 7516
Gene Symbol: XRCC2
XRCC2
O43543 X-ray repair cross complementing 2 83 0.609 0.586 4.2E-07 0.620 limited 1.000 6 0 1999 2013
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
P40692 mutL homolog 1 nucleic acid binding 356 0.424 0.759 5.1E-05 0.520 disputed 1.000 8 0 2001 2017
Entrez Id: 5892
Gene Symbol: RAD51D
RAD51D
O75771 RAD51 paralog D 23 0.707 0.310 1.0E-08 0.510 limited < 0.001 9 1 2000 2017
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
P52701 mutS homolog 6 189 0.495 0.586 2.2E-05 0.510 disputed 1.000 5 1 2002 2018
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
P43246 mutS homolog 2 nucleic acid binding 320 0.437 0.690 0.91 0.510 disputed 1.000 3 0 2003 2017
Entrez Id: 4595
Gene Symbol: MUTYH
MUTYH
Q9UIF7 mutY DNA glycosylase hydrolase; nucleic acid binding 99 0.551 0.621 2.7E-17 0.510 1.000 1 0 2010 2010
Entrez Id: 472
Gene Symbol: ATM
ATM
Q13315 ATM serine/threonine kinase kinase; nucleic acid binding; transferase 486 0.401 0.862 6.0E-46 0.500 definitive 0.923 19 12 1998 2016
Entrez Id: 5395
Gene Symbol: PMS2
PMS2
P54278 PMS1 homolog 2, mismatch repair system component nucleic acid binding 154 0.526 0.586 1.2E-27 0.500 disputed 4 0 1995 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 835 0.341 0.897 1.00 0.500 1 5 2006 2006
Entrez Id: 8493
Gene Symbol: PPM1D
PPM1D
O15297 protein phosphatase, Mg2+/Mn2+ dependent 1D enzyme modulator; hydrolase; phosphatase 112 0.573 0.724 3.5E-11 0.500 limited 0 0
Entrez Id: 8438
Gene Symbol: RAD54L
RAD54L
Q92698 RAD54 like 29 0.676 0.276 3.3E-15 0.500 0 0
Entrez Id: 4072
Gene Symbol: EPCAM
EPCAM
P16422 epithelial cell adhesion molecule 201 0.499 0.690 9.7E-08 0.500 0 0
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
P03372 estrogen receptor 1 nucleic acid binding; receptor; transcription factor 686 0.355 0.897 1.00 0.470 limited 0.857 12 1 1995 2013
Entrez Id: 5888
Gene Symbol: RAD51
RAD51
Q06609 RAD51 recombinase 174 0.517 0.724 3.3E-02 0.460 1.000 8 1 1999 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
P60484 phosphatase and tensin homolog hydrolase; phosphatase 915 0.334 0.828 0.82 0.350 strong 1.000 6 0 2003 2015
Entrez Id: 84464
Gene Symbol: SLX4
SLX4
Q8IY92 SLX4 structure-specific endonuclease subunit 49 0.672 0.517 2.3E-20 0.330 limited 1.000 10 0 2011 2017
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Q92878 RAD50 double strand break repair protein 70 0.600 0.690 1.8E-27 0.330 limited 0.333 6 1 2004 2012
Entrez Id: 6794
Gene Symbol: STK11
STK11
Q15831 serine/threonine kinase 11 231 0.467 0.655 0.99 0.330 strong 1.000 4 0 2000 2015