Source: ALL
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 348
Gene Symbol: APOE
APOE 		P02649 apolipoprotein E 1049 0.338 0.962 1.9E-03 0.400 None 0.956 431 6 1993 2020
Entrez Id: 351
Gene Symbol: APP
APP 		P05067 amyloid beta precursor protein Enzyme modulator 485 0.422 0.846 4.7E-02 0.400 None 0.986 70 5 1991 2019
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1 		P49768 presenilin 1 Enzyme 369 0.469 0.846 0.97 0.400 None 0.938 48 4 1995 2020
Entrez Id: 54209
Gene Symbol: TREM2
TREM2 		Q9NZC2 triggering receptor expressed on myeloid cells 2 239 0.519 0.769 3.3E-09 0.400 None 0.938 32 3 2013 2019
Entrez Id: 1191
Gene Symbol: CLU
CLU 		P10909 clusterin 412 0.426 0.885 7.8E-05 0.400 None 1.000 30 3 2009 2019
Entrez Id: 274
Gene Symbol: BIN1
BIN1 		O00499 bridging integrator 1 163 0.550 0.692 0.78 0.400 None 1.000 28 5 2011 2020
Entrez Id: 8301
Gene Symbol: PICALM
PICALM 		Q13492 phosphatidylinositol binding clathrin assembly protein Transporter 79 0.592 0.538 1.00 0.400 None 0.963 27 1 2009 2018
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40 		O96008 translocase of outer mitochondrial membrane 40 Transporter 113 0.590 0.538 0.99 0.400 None 0.917 24 3 2007 2018
Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7 		Q8IZY2 ATP binding cassette subfamily A member 7 Transporter 70 0.644 0.577 2.1E-55 0.400 None 1.000 19 3 2011 2020
Entrez Id: 4137
Gene Symbol: MAPT
MAPT 		P10636 microtubule associated protein tau 469 0.446 0.923 6.0E-03 0.400 None 0.944 18 1 2003 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE 		P12821 angiotensin I converting enzyme Enzyme 1082 0.328 0.923 1.0E-37 0.400 None 1.000 15 4 1999 2019
Entrez Id: 945
Gene Symbol: CD33
CD33 		P20138 CD33 molecule Receptor 142 0.524 0.769 5.7E-07 0.400 None 1.000 14 2 2011 2019
Entrez Id: 3416
Gene Symbol: IDE
IDE 		P14735 insulin degrading enzyme Enzyme 71 0.604 0.577 6.6E-03 0.400 None 1.000 13 6 2001 2017
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR 		P42898 methylenetetrahydrofolate reductase 985 0.337 0.885 3.2E-10 0.400 None 0.909 11 3 2001 2019
Entrez Id: 590
Gene Symbol: BCHE
BCHE 		P06276 butyrylcholinesterase 392 0.447 0.923 1.1E-13 0.400 None 0.909 11 0 1998 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1 		P56817 beta-secretase 1 Enzyme 120 0.559 0.769 0.88 0.390 None 1.000 10 1 2001 2020
Entrez Id: 5468
Gene Symbol: PPARG
PPARG 		P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 877 0.358 0.885 2.9E-02 0.380 None 0.909 11 2 2005 2018
Entrez Id: 5664
Gene Symbol: PSEN2
PSEN2 		P49810 presenilin 2 Enzyme 146 0.550 0.654 5.4E-04 0.380 None 1.000 11 2 1997 2019
Entrez Id: 2
Gene Symbol: A2M
A2M 		P01023 alpha-2-macroglobulin Enzyme modulator 147 0.529 0.769 4.5E-11 0.370 None 0.800 10 0 1998 2010
Entrez Id: 1471
Gene Symbol: CST3
CST3 		P01034 cystatin C 370 0.436 0.808 3.9E-03 0.370 None 0.778 9 0 2000 2009
Entrez Id: 2041
Gene Symbol: EPHA1
EPHA1 		P21709 EPH receptor A1 Kinase 119 0.544 0.731 1.5E-23 0.370 None 1.000 8 1 2011 2020
Entrez Id: 627
Gene Symbol: BDNF
BDNF 		P23560 brain derived neurotrophic factor Signaling 992 0.345 0.923 0.66 0.370 None 1.000 8 3 2001 2020
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		P29474 nitric oxide synthase 3 706 0.378 0.885 6.7E-07 0.350 None 1.000 7 1 1999 2010
Entrez Id: 1378
Gene Symbol: CR1
CR1 		P17927 complement C3b/C4b receptor 1 (Knops blood group) 129 0.533 0.808 1.6E-35 0.350 None 1.000 7 6 2009 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF 		P01375 tumor necrosis factor Signaling 2724 0.231 0.962 0.80 0.350 None 1.000 6 0 2000 2016