Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 348
Gene Symbol: APOE
APOE
P02649 apolipoprotein E 770 0.352 0.931 1.7E-03 0.400 0.945 240 3 1993 2018
Entrez Id: 351
Gene Symbol: APP
APP
P05067 amyloid beta precursor protein enzyme modulator 371 0.430 0.862 6.2E-02 0.400 1.000 54 1 1991 2018
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
P49768 presenilin 1 calcium-binding protein; hydrolase; protease; signaling molecule 268 0.490 0.690 0.98 0.400 0.933 28 2 1995 2018
Entrez Id: 1191
Gene Symbol: CLU
CLU
P10909 clusterin 266 0.456 0.793 5.7E-05 0.400 1.000 22 3 2009 2015
Entrez Id: 8301
Gene Symbol: PICALM
PICALM
Q13492 phosphatidylinositol binding clathrin assembly protein membrane traffic protein 36 0.639 0.310 1.00 0.400 0.895 20 2 2009 2016
Entrez Id: 6653
Gene Symbol: SORL1
SORL1
Q92673 sortilin related receptor 1 receptor; transporter 69 0.619 0.483 1.1E-09 0.400 1.000 16 4 2007 2018
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
Q9NZC2 triggering receptor expressed on myeloid cells 2 178 0.572 0.552 4.0E-09 0.400 1.000 13 3 2013 2017
Entrez Id: 274
Gene Symbol: BIN1
BIN1
O00499 bridging integrator 1 109 0.573 0.621 0.77 0.400 0.923 13 5 2011 2018
Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
Q8IZY2 ATP binding cassette subfamily A member 7 transporter 46 0.690 0.379 4.5E-55 0.400 0.909 13 2 2011 2018
Entrez Id: 3416
Gene Symbol: IDE
IDE
P14735 insulin degrading enzyme hydrolase; protease 47 0.627 0.483 9.1E-03 0.390 0.889 10 3 2002 2012
Entrez Id: 945
Gene Symbol: CD33
CD33
P20138 CD33 molecule cell adhesion molecule; defense/immunity protein; receptor; signaling molecule; structural protein 81 0.567 0.586 6.3E-07 0.370 1.000 8 1 2011 2018
Entrez Id: 1471
Gene Symbol: CST3
CST3
P01034 cystatin C 167 0.500 0.724 3.9E-03 0.360 0.833 8 0 2000 2009
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
P10636 microtubule associated protein tau 265 0.492 0.724 7.3E-03 0.350 1.000 12 0 2003 2016
Entrez Id: 1636
Gene Symbol: ACE
ACE
P12821 angiotensin I converting enzyme hydrolase; protease 624 0.367 0.897 1.6E-37 0.350 1.000 8 0 1999 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
P42898 methylenetetrahydrofolate reductase 699 0.354 0.828 1.2E-09 0.350 0.800 6 0 2001 2016
Entrez Id: 5664
Gene Symbol: PSEN2
PSEN2
P49810 presenilin 2 hydrolase; protease; signaling molecule 108 0.567 0.517 2.4E-03 0.340 1.000 7 1 1997 2016
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
P37231 peroxisome proliferator activated receptor gamma nucleic acid binding; receptor; transcription factor 540 0.388 0.828 0.14 0.340 1.000 6 0 2005 2018
Entrez Id: 590
Gene Symbol: BCHE
BCHE
P06276 butyrylcholinesterase 219 0.503 0.793 1.1E-12 0.340 0.750 5 0 1999 2013
Entrez Id: 2041
Gene Symbol: EPHA1
EPHA1
P21709 EPH receptor A1 64 0.596 0.586 4.9E-23 0.340 1.000 5 1 2011 2015
Entrez Id: 27328
Gene Symbol: PCDH11X
PCDH11X
Q9BZA7 protocadherin 11 X-linked 17 0.720 0.345 1.9E-02 0.340 1.000 4 1 2009 2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
P29474 nitric oxide synthase 3 467 0.401 0.862 8.9E-07 0.330 1.000 5 1 1999 2010
Entrez Id: 7019
Gene Symbol: TFAM
TFAM
Q00059 transcription factor A, mitochondrial 98 0.565 0.655 0.19 0.330 1.000 4 1 2007 2012
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
P56817 beta-secretase 1 hydrolase; protease 56 0.616 0.517 0.88 0.330 1.000 4 0 2004 2014
Entrez Id: 7124
Gene Symbol: TNF
TNF
P01375 tumor necrosis factor signaling molecule 1640 0.263 0.966 0.80 0.330 1.000 4 0 2006 2016
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
P00749 plasminogen activator, urokinase hydrolase; protease 325 0.434 0.690 2.1E-06 0.330 1.000 3 0 2003 2008