Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
P04626 erb-b2 receptor tyrosine kinase 2 650 0.352 0.862 1.8E-03 0.100 0.970 100 2 1991 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
P03372 estrogen receptor 1 nucleic acid binding; receptor; transcription factor 686 0.355 0.897 1.00 0.100 1.000 29 1 2000 2016
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
P38398 BRCA1, DNA repair associated ligase 411 0.410 0.862 1.8E-28 0.100 0.952 21 0 1999 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
P04637 tumor protein p53 transcription factor 1773 0.251 0.897 0.17 0.100 1.000 13 0 1996 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
P00533 epidermal growth factor receptor 892 0.325 0.862 0.50 0.100 1.000 12 0 2000 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
P51587 BRCA2, DNA repair associated nucleic acid binding 358 0.426 0.793 5.5E-24 0.100 0.917 12 0 1999 2015
Entrez Id: 5241
Gene Symbol: PGR
PGR
P06401 progesterone receptor nucleic acid binding; receptor; transcription factor 230 0.467 0.690 7.2E-02 0.100 0.909 11 0 2000 2016
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 835 0.341 0.897 1.00 0.080 1.000 8 0 2010 2014
Entrez Id: 596
Gene Symbol: BCL2
BCL2
P10415 BCL2, apoptosis regulator signaling molecule 987 0.312 0.862 0.57 0.070 1.000 7 0 1995 2015
Entrez Id: 595
Gene Symbol: CCND1
CCND1
P24385 cyclin D1 enzyme modulator 589 0.365 0.828 0.90 0.060 0.833 6 0 1999 2017
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
Q16665 hypoxia inducible factor 1 subunit alpha nucleic acid binding; transcription factor 586 0.367 0.793 0.97 0.060 1.000 6 0 2003 2013
Entrez Id: 4323
Gene Symbol: MMP14
MMP14
P50281 matrix metallopeptidase 14 hydrolase; protease 240 0.466 0.724 1.00 0.050 0.800 5 0 1998 2017
Entrez Id: 999
Gene Symbol: CDH1
CDH1
P12830 cadherin 1 322 0.432 0.759 0.11 0.040 0.750 4 0 1994 2014
Entrez Id: 7153
Gene Symbol: TOP2A
TOP2A
P11388 DNA topoisomerase II alpha 122 0.542 0.621 1.00 0.040 1.000 4 0 2005 2016
Entrez Id: 2051
Gene Symbol: EPHB6
EPHB6
O15197 EPH receptor B6 36 0.656 0.345 9.5E-08 0.040 1.000 4 0 2009 2011
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
Q15910 enhancer of zeste 2 polycomb repressive complex 2 subunit 425 0.421 0.759 1.00 0.040 1.000 4 0 2003 2014
Entrez Id: 4609
Gene Symbol: MYC
MYC
P01106 MYC proto-oncogene, bHLH transcription factor nucleic acid binding; transcription factor 499 0.382 0.724 1.00 0.040 1.000 4 0 2003 2015
Entrez Id: 960
Gene Symbol: CD44
CD44
P16070 CD44 molecule (Indian blood group) 467 0.389 0.862 2.1E-07 0.030 1.000 3 0 1999 2012
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
P15692 vascular endothelial growth factor A signaling molecule 1174 0.298 0.897 2.7E-05 0.030 0.667 3 0 2006 2018
Entrez Id: 3082
Gene Symbol: HGF
HGF
P14210 hepatocyte growth factor hydrolase; protease 478 0.394 0.793 1.00 0.030 1.000 3 0 2001 2007
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
P08253 matrix metallopeptidase 2 hydrolase; protease 628 0.373 0.862 0.84 0.030 0.667 3 0 1998 2015
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
P05121 serpin family E member 1 enzyme modulator 506 0.384 0.793 4.7E-02 0.030 1.000 3 0 2007 2009
Entrez Id: 2113
Gene Symbol: ETS1
ETS1
P14921 ETS proto-oncogene 1, transcription factor nucleic acid binding; signaling molecule; transcription factor 198 0.481 0.690 0.74 0.030 1.000 3 0 2001 2011
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
P00749 plasminogen activator, urokinase hydrolase; protease 325 0.434 0.690 2.1E-06 0.030 1.000 3 0 2002 2009
Entrez Id: 382
Gene Symbol: ARF6
ARF6
P62330 ADP ribosylation factor 6 34 0.681 0.448 0.74 0.030 1.000 3 0 2004 2014