Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
P35222 catenin beta 1 412 0.417 0.759 1.00 0.840 1.000 6 1 1999 2016
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
P38398 BRCA1, DNA repair associated ligase 411 0.410 0.862 1.8E-28 0.700 0.988 155 5 1994 2016
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
P51587 BRCA2, DNA repair associated nucleic acid binding 358 0.426 0.793 5.5E-24 0.700 1.000 63 1 1996 2015
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
P04626 erb-b2 receptor tyrosine kinase 2 650 0.352 0.862 1.8E-03 0.700 0.936 59 1 1990 2017
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
P01116 KRAS proto-oncogene, GTPase enzyme modulator 886 0.350 0.724 9.0E-04 0.700 1.000 20 2 1991 2013
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 835 0.341 0.897 1.00 0.670 1.000 15 5 2001 2013
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
P60484 phosphatase and tensin homolog hydrolase; phosphatase 915 0.334 0.828 0.82 0.660 0.800 7 0 1998 2011
Entrez Id: 207
Gene Symbol: AKT1
AKT1
P31749 AKT serine/threonine kinase 1 calcium-binding protein; kinase; transfer/carrier protein; transferase 760 0.355 0.862 0.98 0.640 1.000 8 1 2005 2016
Entrez Id: 4978
Gene Symbol: OPCML
OPCML
Q14982 opioid binding protein/cell adhesion molecule like 36 0.663 0.517 0.25 0.630 < 0.001 3 1 2003 2007
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
Q9BX63 BRCA1 interacting protein C-terminal helicase 1 nucleic acid binding 89 0.586 0.552 4.8E-17 0.600 21 28 2005 2018
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
P40692 mutL homolog 1 nucleic acid binding 356 0.424 0.759 5.1E-05 0.590 0.833 10 0 1997 2009
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
P43246 mutS homolog 2 nucleic acid binding 320 0.437 0.690 0.91 0.540 1.000 5 1 1994 2016
Entrez Id: 6597
Gene Symbol: SMARCA4
SMARCA4
P51532 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 nucleic acid binding 212 0.503 0.759 1.00 0.510 1.000 4 0 2014 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
P04637 tumor protein p53 transcription factor 1773 0.251 0.897 0.17 0.500 0.943 67 0 1992 2016
Entrez Id: 898
Gene Symbol: CCNE1
CCNE1
P24864 cyclin E1 enzyme modulator 74 0.590 0.517 0.96 0.500 1 0 2011 2011
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
O96017 checkpoint kinase 2 195 0.494 0.621 1.2E-23 0.440 0.667 4 0 2002 2007
Entrez Id: 580
Gene Symbol: BARD1
BARD1
Q99728 BRCA1 associated RING domain 1 54 0.624 0.379 2.2E-24 0.440 1.000 4 2 1998 2006
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
O43502 RAD51 paralog C 80 0.614 0.517 1.1E-13 0.410 < 0.001 2 0 2010 2012
Entrez Id: 5395
Gene Symbol: PMS2
PMS2
P54278 PMS1 homolog 2, mismatch repair system component nucleic acid binding 154 0.526 0.586 1.2E-27 0.410 1 0 2006 2006
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
Q86YC2 partner and localizer of BRCA2 122 0.569 0.552 7.3E-20 0.410 1.000 1 1 2008 2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
P00533 epidermal growth factor receptor 892 0.325 0.862 0.50 0.400 1.000 24 0 1996 2016
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
Q8WXI7 mucin 16, cell surface associated 80 0.580 0.517 1.1E-109 0.400 0.882 23 0 1988 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
P15056 B-Raf proto-oncogene, serine/threonine kinase 871 0.352 0.793 1.00 0.400 0.909 14 1 2002 2015
Entrez Id: 22800
Gene Symbol: RRAS2
RRAS2
P62070 RAS related 2 enzyme modulator 26 0.696 0.207 0.98 0.400 1 1 1994 1994
Entrez Id: 5892
Gene Symbol: RAD51D
RAD51D
O75771 RAD51 paralog D 23 0.707 0.310 1.0E-08 0.400 1 0 2011 2011