Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 324
Gene Symbol: APC
APC
P25054 APC, WNT signaling pathway regulator 462 0.397 0.828 1.00 0.100 0.920 50 2 1994 2016
Entrez Id: 4595
Gene Symbol: MUTYH
MUTYH
Q9UIF7 mutY DNA glycosylase hydrolase; nucleic acid binding 99 0.551 0.621 2.7E-17 0.100 1.000 36 1 2003 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
P04637 tumor protein p53 transcription factor 1773 0.251 0.897 0.17 0.100 0.964 28 1 1992 2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
P35354 prostaglandin-endoperoxide synthase 2 oxidoreductase 832 0.338 0.897 1.00 0.100 0.955 22 1 1994 2012
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
P42898 methylenetetrahydrofolate reductase 699 0.354 0.828 1.2E-09 0.100 0.941 17 1 1999 2016
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
P09488 glutathione S-transferase mu 1 423 0.403 0.828 2.0E-03 0.090 0.667 9 1 1995 2012
Entrez Id: 4513
Gene Symbol: COX2
COX2
P00403 cytochrome c oxidase subunit II oxidoreductase 494 0.397 0.862 0.090 1.000 9 0 1994 2008
Entrez Id: 7421
Gene Symbol: VDR
VDR
P11473 vitamin D receptor nucleic acid binding; receptor; transcription factor 533 0.390 0.793 6.3E-05 0.080 1.000 8 0 2001 2012
Entrez Id: 1559
Gene Symbol: CYP2C9
CYP2C9
P11712 cytochrome P450 family 2 subfamily C member 9 129 0.542 0.759 1.8E-10 0.060 1.000 6 2 2004 2014
Entrez Id: 5424
Gene Symbol: POLD1
POLD1
P28340 DNA polymerase delta 1, catalytic subunit 144 0.546 0.655 2.2E-06 0.060 1.000 6 0 2013 2016
Entrez Id: 960
Gene Symbol: CD44
CD44
P16070 CD44 molecule (Indian blood group) 467 0.389 0.862 2.1E-07 0.060 1.000 6 0 1994 2003
Entrez Id: 5426
Gene Symbol: POLE
POLE
Q07864 DNA polymerase epsilon, catalytic subunit 66 0.616 0.345 1.8E-25 0.060 1.000 6 0 2013 2016
Entrez Id: 4953
Gene Symbol: ODC1
ODC1
P11926 ornithine decarboxylase 1 lyase 127 0.532 0.759 0.19 0.050 1.000 5 0 2006 2012
Entrez Id: 2952
Gene Symbol: GSTT1
GSTT1
P30711 glutathione S-transferase theta 1 356 0.419 0.862 1.3E-04 0.050 0.400 5 0 2001 2012
Entrez Id: 10
Gene Symbol: NAT2
NAT2
P11245 N-acetyltransferase 2 transferase 228 0.466 0.828 4.1E-06 0.050 0.800 5 0 2003 2015
Entrez Id: 2052
Gene Symbol: EPHX1
EPHX1
P07099 epoxide hydrolase 1 hydrolase; protease 150 0.510 0.759 3.7E-09 0.050 0.800 5 2 2001 2012
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
P01116 KRAS proto-oncogene, GTPase enzyme modulator 886 0.350 0.724 9.0E-04 0.050 0.800 5 0 1995 2012
Entrez Id: 4548
Gene Symbol: MTR
MTR
Q99707 5-methyltetrahydrofolate-homocysteine methyltransferase 196 0.493 0.724 2.6E-10 0.050 1.000 5 1 1999 2013
Entrez Id: 54578
Gene Symbol: UGT1A6
UGT1A6
P19224 UDP glucuronosyltransferase family 1 member A6 51 0.636 0.414 2.9E-07 0.040 1.000 4 2 2005 2012
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
P04818 thymidylate synthetase transferase 256 0.457 0.759 0.76 0.040 1.000 4 0 2002 2013
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
P15559 NAD(P)H quinone dehydrogenase 1 230 0.467 0.724 1.0E-09 0.040 1.000 4 2 2005 2014
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
P09211 glutathione S-transferase pi 1 398 0.406 0.828 7.1E-02 0.040 0.750 4 2 2001 2012
Entrez Id: 596
Gene Symbol: BCL2
BCL2
P10415 BCL2, apoptosis regulator signaling molecule 987 0.312 0.862 0.57 0.040 0.750 4 0 1994 2007
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
P42771 Q8N726 cyclin dependent kinase inhibitor 2A 891 0.321 0.828 0.38 0.030 1.000 3 0 2000 2010
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
P16455 O-6-methylguanine-DNA methyltransferase 293 0.438 0.759 1.1E-07 0.030 1.000 3 0 2009 2015