Source: ALL
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		P60484 phosphatase and tensin homolog Enzyme 1349 0.305 0.923 0.26 0.160 None 0.833 6 1 2002 2016
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		P38398 BRCA1 DNA repair associated Enzyme 747 0.367 0.923 9.2E-29 0.100 None 1.000 28 1 1996 2020
Entrez Id: 7157
Gene Symbol: TP53
TP53 		P04637 tumor protein p53 Transcription factor 2494 0.236 0.962 0.53 0.100 None 1.000 18 2 1994 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		P51587 BRCA2 DNA repair associated Nucleic acid binding 656 0.379 0.846 2.4E-25 0.100 None 0.929 14 1 1996 2019
Entrez Id: 8314
Gene Symbol: BAP1
BAP1 		Q92560 BRCA1 associated protein 1 Enzyme 299 0.454 0.731 0.99 0.090 None 1.000 9 0 2011 2019
Entrez Id: 4221
Gene Symbol: MEN1
MEN1 		O00255 menin 1 364 0.444 0.808 1.00 0.080 None 1.000 8 0 1997 2014
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		P40692 mutL homolog 1 Nucleic acid binding 526 0.399 0.808 3.4E-05 0.060 None 0.667 6 0 2002 2019
Entrez Id: 5979
Gene Symbol: RET
RET 		P07949 ret proto-oncogene Kinase 607 0.392 0.885 1.00 0.050 None 1.000 5 0 1995 2019
Entrez Id: 115761
Gene Symbol: ARL11
ARL11 		Q969Q4 ADP ribosylation factor like GTPase 11 35 0.670 0.423 5.3E-03 0.050 None 1.000 5 3 2005 2006
Entrez Id: 4360
Gene Symbol: MRC1
MRC1 		P22897 mannose receptor C-type 1 431 0.413 0.846 0.94 0.050 None 1.000 5 0 2002 2017
Entrez Id: 4436
Gene Symbol: MSH2
MSH2 		P43246 mutS homolog 2 Nucleic acid binding 490 0.406 0.808 0.90 0.040 None 1.000 4 2 2007 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		Q86YC2 partner and localizer of BRCA2 260 0.485 0.769 3.0E-19 0.040 None 1.000 4 1 2013 2017
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A 		P42771 Q8N726 cyclin dependent kinase inhibitor 2A 1314 0.300 0.885 0.39 0.040 None 1.000 4 0 1995 2014
Entrez Id: 4683
Gene Symbol: NBN
NBN 		O60934 nibrin Nucleic acid binding 291 0.467 0.808 2.2E-16 0.030 None 1.000 3 0 2008 2016
Entrez Id: 7428
Gene Symbol: VHL
VHL 		P40337 von Hippel-Lindau tumor suppressor Enzyme 372 0.443 0.846 8.0E-02 0.030 None 1.000 3 0 1997 2013
Entrez Id: 5395
Gene Symbol: PMS2
PMS2 		P54278 PMS1 homolog 2, mismatch repair system component Nucleic acid binding 244 0.484 0.808 4.5E-27 0.030 None 0.667 3 3 2014 2017
Entrez Id: 4361
Gene Symbol: MRE11
MRE11 		P49959 MRE11 homolog, double strand break repair nuclease 171 0.527 0.808 1.3E-12 0.020 None 1.000 2 0 2008 2017
Entrez Id: 55655
Gene Symbol: NLRP2
NLRP2 		Q9NX02 NLR family pyrin domain containing 2 155 0.515 0.731 1.4E-38 0.020 None 1.000 2 0 2008 2008
Entrez Id: 472
Gene Symbol: ATM
ATM 		Q13315 ATM serine/threonine kinase Kinase 684 0.374 0.885 5.6E-47 0.020 None 1.000 2 0 2019 2020
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		P52701 mutS homolog 6 Nucleic acid binding 296 0.462 0.731 3.7E-05 0.020 None 0.500 2 0 2008 2017
Entrez Id: 641
Gene Symbol: BLM
BLM 		P54132 BLM RecQ like helicase 158 0.535 0.808 1.5E-15 0.020 None 1.000 2 0 2001 2005
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1228 0.319 0.846 1.00 0.020 None 1.000 2 0 2010 2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		P12830 cadherin 1 508 0.401 0.808 0.15 0.020 None 1.000 2 0 2004 2010
Entrez Id: 54797
Gene Symbol: MED18
MED18 		Q9BUE0 mediator complex subunit 18 24 0.736 0.423 1.6E-04 0.010 None 1.000 1 0 2016 2016
Entrez Id: 9071
Gene Symbol: CLDN10
CLDN10 		P78369 claudin 10 Cell-cell junction 62 0.626 0.577 8.4E-04 0.010 None 1.000 1 0 2018 2018