Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
P04626 erb-b2 receptor tyrosine kinase 2 650 0.352 0.862 1.8E-03 0.700 0.958 612 14 1987 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
P03372 estrogen receptor 1 nucleic acid binding; receptor; transcription factor 686 0.355 0.897 1.00 0.700 0.965 486 6 1988 2018
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
P38398 BRCA1, DNA repair associated ligase 411 0.410 0.862 1.8E-28 0.700 0.937 319 45 1987 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
P04637 tumor protein p53 transcription factor 1773 0.251 0.897 0.17 0.700 0.971 244 86 1983 2016
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
P51587 BRCA2, DNA repair associated nucleic acid binding 358 0.426 0.793 5.5E-24 0.700 0.940 156 38 1995 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 835 0.341 0.897 1.00 0.700 0.956 71 34 2005 2018
Entrez Id: 857
Gene Symbol: CAV1
CAV1
Q03135 caveolin 1 enzyme modulator; membrane traffic protein; structural protein; transmembrane receptor regulatory/adaptor protein 421 0.416 0.828 7.2E-03 0.600 1.000 19 0 1999 2013
Entrez Id: 4312
Gene Symbol: MMP1
MMP1
P03956 matrix metallopeptidase 1 hydrolase; protease 388 0.415 0.793 6.2E-18 0.600 1.000 16 0 1997 2015
Entrez Id: 580
Gene Symbol: BARD1
BARD1
Q99728 BRCA1 associated RING domain 1 54 0.624 0.379 2.2E-24 0.550 1.000 5 1 2004 2009
Entrez Id: 4214
Gene Symbol: MAP3K1
MAP3K1
Q13233 mitogen-activated protein kinase kinase kinase 1 92 0.569 0.586 1.00 0.530 4 0 2007 2009
Entrez Id: 207
Gene Symbol: AKT1
AKT1
P31749 AKT serine/threonine kinase 1 calcium-binding protein; kinase; transfer/carrier protein; transferase 760 0.355 0.862 0.98 0.500 1.000 52 1 2002 2017
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
O96017 checkpoint kinase 2 195 0.494 0.621 1.2E-23 0.500 0.750 49 3 2002 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
P60484 phosphatase and tensin homolog hydrolase; phosphatase 915 0.334 0.828 0.82 0.500 1.000 38 5 1999 2017
Entrez Id: 472
Gene Symbol: ATM
ATM
Q13315 ATM serine/threonine kinase kinase; nucleic acid binding; transferase 486 0.401 0.862 6.0E-46 0.500 0.818 37 2 1996 2015
Entrez Id: 2065
Gene Symbol: ERBB3
ERBB3
P21860 erb-b2 receptor tyrosine kinase 3 222 0.473 0.690 6.7E-15 0.500 1.000 28 3 1990 2017
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
P21802 fibroblast growth factor receptor 2 665 0.398 0.759 1.00 0.500 0.889 20 4 1991 2016
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
P01112 HRas proto-oncogene, GTPase enzyme modulator 545 0.404 0.828 8.7E-02 0.500 0.875 16 7 1989 2016
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
Q86YC2 partner and localizer of BRCA2 122 0.569 0.552 7.3E-20 0.500 1.000 12 1 2006 2017
Entrez Id: 167465
Gene Symbol: ZNF366
ZNF366
Q8N895 zinc finger protein 366 transcription factor 17 0.799 0.310 7.2E-02 0.500 2 0 2010 2011
Entrez Id: 9968
Gene Symbol: MED12
MED12
Q93074 mediator complex subunit 12 nucleic acid binding; transcription factor 266 0.528 0.655 1.00 0.420 1.000 5 1 2015 2016
Entrez Id: 55294
Gene Symbol: FBXW7
FBXW7
Q969H0 F-box and WD repeat domain containing 7 enzyme modulator 140 0.511 0.759 1.00 0.420 < 0.001 3 4 2008 2016
Entrez Id: 5241
Gene Symbol: PGR
PGR
P06401 progesterone receptor nucleic acid binding; receptor; transcription factor 230 0.467 0.690 7.2E-02 0.400 0.971 96 0 1988 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
P00533 epidermal growth factor receptor 892 0.325 0.862 0.50 0.400 0.956 82 0 1990 2016
Entrez Id: 595
Gene Symbol: CCND1
CCND1
P24385 cyclin D1 enzyme modulator 589 0.365 0.828 0.90 0.400 1.000 63 0 1992 2014
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
P35354 prostaglandin-endoperoxide synthase 2 oxidoreductase 832 0.338 0.897 1.00 0.400 1.000 56 0 2001 2017