Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 324
Gene Symbol: APC
APC
P25054 APC, WNT signaling pathway regulator 462 0.397 0.828 1.00 0.900 strong 0.942 318 6 1990 2018
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
P40692 mutL homolog 1 nucleic acid binding 356 0.424 0.759 5.1E-05 0.700 strong 0.963 388 23 1993 2018
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
P43246 mutS homolog 2 nucleic acid binding 320 0.437 0.690 0.91 0.700 strong 0.948 230 14 1993 2018
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
Q13485 SMAD family member 4 transcription factor 426 0.430 0.759 1.00 0.700 strong 0.964 58 1 1996 2018
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
Q9NQB0 transcription factor 7 like 2 145 0.538 0.621 0.99 0.700 0.917 27 2 1999 2018
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
P08253 matrix metallopeptidase 2 hydrolase; protease 628 0.373 0.862 0.84 0.700 1.000 17 3 2003 2018
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
P01116 KRAS proto-oncogene, GTPase enzyme modulator 886 0.350 0.724 9.0E-04 0.600 0.964 481 8 1993 2018
Entrez Id: 673
Gene Symbol: BRAF
BRAF
P15056 B-Raf proto-oncogene, serine/threonine kinase 871 0.352 0.793 1.00 0.600 0.968 382 6 2002 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 835 0.341 0.897 1.00 0.600 0.988 161 6 2003 2018
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
P52701 mutS homolog 6 189 0.495 0.586 2.2E-05 0.600 strong 0.962 85 35 1988 2018
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
P35222 catenin beta 1 412 0.417 0.759 1.00 0.600 0.957 52 1 1997 2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
P08183 ATP binding cassette subfamily B member 1 hydrolase; protease 606 0.371 0.828 1.3E-05 0.600 1.000 30 5 1996 2018
Entrez Id: 1630
Gene Symbol: DCC
DCC
P43146 DCC netrin 1 receptor 156 0.504 0.655 0.99 0.600 0.923 27 1 1990 2015
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
P01111 NRAS proto-oncogene, GTPase enzyme modulator 477 0.420 0.690 0.53 0.600 0.955 22 2 1993 2018
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
P17936 insulin like growth factor binding protein 3 enzyme modulator 237 0.464 0.759 0.91 0.600 0.941 19 4 2003 2016
Entrez Id: 5424
Gene Symbol: POLD1
POLD1
P28340 DNA polymerase delta 1, catalytic subunit 144 0.546 0.655 2.2E-06 0.600 strong 1.000 13 2 1995 2018
Entrez Id: 5426
Gene Symbol: POLE
POLE
Q07864 DNA polymerase epsilon, catalytic subunit 66 0.616 0.345 1.8E-25 0.600 strong 1.000 13 1 2013 2018
Entrez Id: 5979
Gene Symbol: RET
RET
P07949 ret proto-oncogene 452 0.418 0.724 1.00 0.580 1.000 10 0 2008 2016
Entrez Id: 3791
Gene Symbol: KDR
KDR
P35968 kinase insert domain receptor 343 0.423 0.724 1.00 0.580 1.000 9 0 2008 2017
Entrez Id: 6794
Gene Symbol: STK11
STK11
Q15831 serine/threonine kinase 11 231 0.467 0.655 0.99 0.550 strong 1.000 6 3 1998 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
P22607 fibroblast growth factor receptor 3 558 0.417 0.759 1.8E-05 0.540 1.000 4 1 2000 2016
Entrez Id: 2070
Gene Symbol: EYA4
EYA4
O95677 EYA transcriptional coactivator and phosphatase 4 52 0.645 0.414 6.3E-02 0.530 1.000 5 1 2006 2016
Entrez Id: 23345
Gene Symbol: SYNE1
SYNE1
Q8NF91 spectrin repeat containing nuclear envelope protein 1 95 0.594 0.621 9.1E-50 0.520 1.000 5 3 2006 2015
Entrez Id: 51466
Gene Symbol: EVL
EVL
Q9UI08 Enah/Vasp-like 13 0.785 0.172 1.00 0.520 1.000 5 1 2006 2016
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
O95477 ATP binding cassette subfamily A member 1 transporter 236 0.484 0.793 3.5E-12 0.520 1.000 4 1 2003 2013