Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 351
Gene Symbol: APP
APP
P05067 amyloid beta precursor protein enzyme modulator 371 0.430 0.862 6.2E-02 0.400 0.930 187 9 1988 2016
Entrez Id: 4129
Gene Symbol: MAOB
MAOB
P27338 monoamine oxidase B nucleic acid binding; oxidoreductase; transferase 82 0.575 0.724 1.00 0.300 1 0 1995 1995
Entrez Id: 7276
Gene Symbol: TTR
TTR
P02766 transthyretin transfer/carrier protein; transporter 258 0.471 0.897 0.55 0.100 0.946 37 0 1981 2017
Entrez Id: 348
Gene Symbol: APOE
APOE
P02649 apolipoprotein E 770 0.352 0.931 1.7E-03 0.100 0.917 36 0 1995 2014
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
F7VJQ1 P04156 prion protein 310 0.474 0.897 7.2E-04 0.100 0.968 31 3 1989 2016
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
P49768 presenilin 1 calcium-binding protein; hydrolase; protease; signaling molecule 268 0.490 0.690 0.98 0.100 0.850 20 2 1997 2016
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
P56817 beta-secretase 1 hydrolase; protease 56 0.616 0.517 0.88 0.100 1.000 17 0 1999 2015
Entrez Id: 3375
Gene Symbol: IAPP
IAPP
P10997 islet amyloid polypeptide signaling molecule 87 0.559 0.655 3.1E-03 0.100 1.000 16 0 1989 2016
Entrez Id: 325
Gene Symbol: APCS
APCS
P02743 amyloid P component, serum 88 0.565 0.655 3.0E-02 0.100 0.846 13 0 1993 2016
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
P10636 microtubule associated protein tau 265 0.492 0.724 7.3E-03 0.100 1.000 13 1 1999 2018
Entrez Id: 1471
Gene Symbol: CST3
CST3
P01034 cystatin C 167 0.500 0.724 3.9E-03 0.090 1.000 9 0 1987 2016
Entrez Id: 335
Gene Symbol: APOA1
APOA1
P02647 apolipoprotein A1 255 0.463 0.759 5.5E-04 0.080 0.750 8 0 1998 2016
Entrez Id: 4311
Gene Symbol: MME
MME
P08473 membrane metalloendopeptidase hydrolase; protease 237 0.461 0.690 7.0E-17 0.070 1.000 7 0 2004 2009
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
P14136 glial fibrillary acidic protein 220 0.484 0.759 1.2E-06 0.050 1.000 5 0 2001 2016
Entrez Id: 12
Gene Symbol: SERPINA3
SERPINA3
P01011 serpin family A member 3 enzyme modulator 92 0.572 0.690 8.1E-14 0.050 1.000 5 0 1988 2001
Entrez Id: 4069
Gene Symbol: LYZ
LYZ
P61626 lysozyme 79 0.609 0.690 3.7E-06 0.040 0.750 4 0 1999 2006
Entrez Id: 7045
Gene Symbol: TGFBI
TGFBI
Q15582 transforming growth factor beta induced cell adhesion molecule; signaling molecule 160 0.510 0.724 8.4E-07 0.040 0.750 4 4 2005 2015
Entrez Id: 43
Gene Symbol: ACHE
ACHE
P22303 acetylcholinesterase (Cartwright blood group) hydrolase; protease 219 0.494 0.793 1.00 0.040 1.000 4 0 1996 2009
Entrez Id: 2934
Gene Symbol: GSN
GSN
P06396 gelsolin cytoskeletal protein 168 0.498 0.828 3.4E-11 0.040 1.000 4 0 1990 2003
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
Q9NZC2 triggering receptor expressed on myeloid cells 2 178 0.572 0.552 4.0E-09 0.040 1.000 4 0 2011 2016
Entrez Id: 7124
Gene Symbol: TNF
TNF
P01375 tumor necrosis factor signaling molecule 1640 0.263 0.966 0.80 0.030 1.000 3 0 1999 2012
Entrez Id: 796
Gene Symbol: CALCA
CALCA
P01258 P06881 calcitonin related polypeptide alpha signaling molecule 274 0.456 0.828 1.4E-02 0.030 1.000 3 0 1988 1992
Entrez Id: 7781
Gene Symbol: SLC30A3
SLC30A3
Q99726 solute carrier family 30 member 3 transporter 26 0.762 0.207 0.44 0.030 1.000 3 0 2002 2012
Entrez Id: 6855
Gene Symbol: SYP
SYP
P08247 synaptophysin membrane traffic protein 101 0.550 0.690 0.90 0.030 1.000 3 0 1993 2005
Entrez Id: 6279
Gene Symbol: S100A8
S100A8
P05109 S100 calcium binding protein A8 calcium-binding protein; signaling molecule 199 0.481 0.828 0.14 0.030 1.000 3 0 2005 2013