Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6752
Gene Symbol: SSTR2
SSTR2
0.070 AlteredExpression disease BEFREE The high expression of somatostatin receptor 2 (SST2) in growth hormone (GH)-secreting tumors represents the rationale for the clinical use of somatostatin analogs (SSAs) in acromegaly. 31574507 2019
Entrez Id: 6752
Gene Symbol: SSTR2
SSTR2
0.070 AlteredExpression disease BEFREE To investigate in patients with active acromegaly whether response to SRL treatment correlates to PAS-LAR treatment and to what extent SSTR2 and SSTR5 expression are correlated to the response to PAS-LAR treatment. 30346538 2019
Entrez Id: 6752
Gene Symbol: SSTR2
SSTR2
0.070 AlteredExpression disease BEFREE Our data have reinforced the importance of personalized treatment of patients with acromegaly according to the clinical, biochemical, molecular, and morphological disease markers and suggest that combined treatment with pasireotide and pegvisomant can induce disease control in tumors with low SSTR2 expression, resistant to conventional SSAs (alone or combined with pegvisomant) and to new-generation SSAs alone (pasireotide). 31219586 2019
Entrez Id: 6752
Gene Symbol: SSTR2
SSTR2
0.070 Biomarker disease BEFREE Classic somatostatin analogues aimed at somatostatin receptor type 2, such as octreotide and lanreotide, represent the mainstay of medical treatment for acromegaly. 28835453 2017
Entrez Id: 6752
Gene Symbol: SSTR2
SSTR2
0.070 AlteredExpression disease BEFREE SSTR2 and 5 expression was tested by IHC (n=37), RT/PCR (n=36) or both (n=13) in GH-secreting adenomas from 60 patients with acromegaly who had undergone pituitary surgery; 36 had been treated preoperatively with octreotide LAR for 3-6 months, and were categorized as responders (achievement of GH <2.5ng/mL and a normal age-adjusted IGF-1), partial responders (GH and IGF-1 reduction >50% and >30%, respectively) or non-responders. 25008035 2014
Entrez Id: 6752
Gene Symbol: SSTR2
SSTR2
0.070 Biomarker disease BEFREE Reduced expression of the somatostatin receptor subtype 2 (SSTR2) has been suggested as an explanation for the poor response to octreotide in acromegaly, but studies correlating levels of SSTR2 mRNA to octreotide efficacy have been contradictory. 17941904 2008
Entrez Id: 6752
Gene Symbol: SSTR2
SSTR2
0.070 GeneticVariation disease BEFREE Mutations of the somatostatin receptor type 2 A and the gip oncogene are unlikely to be involved in the pathogenesis of acromegaly. 10651751 2000