Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 AlteredExpression group BEFREE Immunocytochemical staining showed that the expression of LKB1 was significantly decreased in adenocarcinoma and mucinous adenocarcinoma tissues, and this reduced expression induced the invasion and metastasis of CRC. 30483811 2019
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 Biomarker group BEFREE Alterations characteristic of adenocarcinoma (EGFR, KRAS, ALK receptor tyrosine kinase [ALK], ROS1, and serine/threonine kinase 11 [STK11]) were detected in the LCC-AD subgroup but not in LCC-SqCC, whereas squamous-lineage alterations (phosphatidylinositol-4,5-biphosphate 3-kinase catalytic subunit alpha [PIK3CA], SRY-box 2 [SOX2], fibroblast growth factor receptor 1 [FGFR1], and AKT1) were detected in the LCC-SqCC subgroup but not in the LCC-AD group. 30978501 2019
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 GeneticVariation group BEFREE Instead, concurrent mutations in TP53 and STK11 were shown to confer poor survival in the KRAS-positive adenocarcinoma subgroup. 30885352 2019
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 GeneticVariation group BEFREE Ion AmpliSeq Cancer Panel detected 9 potentially actionable variants in 29 adenocarcinomas that were wild type by the 8-gene panel testing (9 of 29, 31.0%) in the following genes: ERBB2 (3 of 29, 10.3%), STK11 (2 of 29, 6.8%), PTEN (2 of 29, 6.8%), FBXW7 (1 of 29, 3.4%), and BRAF G469A (1 of 29, 3.4%). 29219616 2018
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 GeneticVariation group BEFREE APC:T1556fs and STK11 mutations found in duodenal adenomas/ACs highlight the importance of proteins encoded by these genes in tumor development. 29525853 2018
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 AlteredExpression group BEFREE The high level of cytoplasmic LKB1 expression was an independent risk factor for poor overall survival in patients with adenocarcinoma. 30033530 2018
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 AlteredExpression group BEFREE LKB1 inactivation occurs in a subset of esophageal adenocarcinomas and is sufficient to drive tumor cell proliferation. 29370903 2018
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 AlteredExpression group BEFREE LKB1 protein expression and Smad1 phosphorylation analysis in a cohort of non-small cell lung cancer patients demonstrated a negative correlation predominantly in a subset enriched in adenocarcinomas. 26701726 2016
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 GeneticVariation group BEFREE Taken together, our findings define new personalized therapeutic strategies that may be rapidly translated into clinical use for the treatment of KRAS/LKB1-mutant adenocarcinomas and squamous cell tumors. 26574479 2015
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 AlteredExpression group BEFREE Multivariate analysis indicated that adenocarcinoma (P<0.05), lymph node metastasis (P<0.05), advanced TNM stage (P<0.001) and reduced expression of LKB1 (P<0.05) and Beclin1 (P<0.001) are all independent prognostic indicators for the survival of NSCLC patients. 25175672 2014
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 GeneticVariation group BEFREE For adenocarcinoma, remaining four epitypes were associated with unsupervised and supervised gene expression phenotypes, and differences in molecular features, including global hypomethylation, promoter hypermethylation, genomic instability, expression of proliferation-associated genes, and mutations in KRAS, TP53, KEAP1, SMARCA4, and STK11. 25278450 2014
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 GeneticVariation group BEFREE PJS is a rare hereditary disease, which may be associated with the development of poor outcome adenocarcinomas and LKB1-gene mutations. 24054548 2013
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 GeneticVariation group BEFREE The three most frequently altered genes in a subgroup of smokers with adenocarcinoma were EGFR (22.0%), STK11 (19.0%), and KRAS (12.0%). 22768234 2012
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 Biomarker group BEFREE Whereas CUL2 mRNA expression levels of greater than 1.7 was predictive for major response (p = 0.02) in adeno- and squamous cell carcinoma, STK11 was predominantly response predictive for adenocarcinomas. 20712528 2010
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 Biomarker group LHGDN Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients. 18594528 2008
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 Biomarker group CTD_human LKB1 modulates lung cancer differentiation and metastasis. 17676035 2007
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 AlteredExpression group LHGDN LKB1 modulates lung cancer differentiation and metastasis. 17676035 2007
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 GeneticVariation group LHGDN Prevalence and specificity of LKB1 genetic alterations in lung cancers. 17384680 2007
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 GeneticVariation group BEFREE We sequenced the LKB1 gene in 22 lung cancer cell lines and 100 Japanese patients with lung cancer (including 81 adenocarcinomas, 14 squamous cell carcinomas and five other histological types) who had undergone curative pulmonary resection. 17711506 2007
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 GeneticVariation group BEFREE Genotype-phenotype analysis did not yield any significant differences between patients carrying mutations in LKB1/STK11 versus those without mutations, even with respect to primary biliary adenocarcinoma. 17404884 2007
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 GeneticVariation group BEFREE Acquired mutations in LKB1 are rarely observed in most sporadic tumor types except for adenocarcinomas of the lung where up to 50% harbor inactivating mutations. 16822578 2006
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 GeneticVariation group BEFREE The inactivation of Stk11 in 27% (6/22) of IPMNs versus 7% (4/56) of pancreatic adenocarcinomas suggests genetic disparities in the pathogenesis of these closely related neoplasms. 12861065 2003
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 GeneticVariation group LHGDN Somatic mutations of the STK11 gene were confirmed in 6 (55%) of the 11 mucinous MDAs and 1 (5%) of the 19 mucinous adenocarcinomas, but not in the 5 nonmucinous adenocarcinomas, the 15 squamous cell carcinomas, nor the 5 endocervical glands with gastric metaplasia. 12533684 2003
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 AlteredExpression group BEFREE Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. 12097271 2002
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.400 AlteredExpression group LHGDN Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. 12097271 2002